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Obstetric outcomes of monochorionic pregnancies conceived following assisted reproductive technology: A retrospective study.

Mascarenhas M, Kamath MS, Muthukumar K, Mangalaraj AM, Chandy A, Aleyamma T - J Hum Reprod Sci (2014)

Bottom Line: Among triplet pregnancies with a monochorionic component, the live birth rate was only 25%.Monochorionic pregnancies following ART have poorer obstetric outcomes when compared to dichorionic pregnancies.For monochorionic pregnancies following ART, intensive antenatal surveillance at a tertiary level obstetric and neonatal center may help optimize the outcome.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Unit, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

ABSTRACT

Objectives: The overwhelming numbers of twins following assisted reproductive technology (ART) are dichorionic twins, but monochorionic twins account for around 0.9% of post ART pregnancies. The data for post ART-monochorionic pregnancy outcomes are scarce due to the rarity of this condition. Hence, we evaluated the obstetric outcomes of monochorionic and dichorionic pregnancies conceived on ART.

Settings: University teaching hospital.

Study design: A case-control study of monochorionic diamniotic (MCDA) and dichorionic diamniotic (DCDA) pregnancies conceived following ART treatment. Charts of all women who conceived following ART from 2008 to 2013 were screened. Among them, the monochorionic twins diagnosed in the first trimester were included and their obstetric outcome was followed-up. For comparison, an equal number of dichorionic twin pregnancies from age and body mass index matched mothers was selected.

Results: The baseline clinical characteristics were similar between the two groups. MCDA group had a higher miscarriage rate (50%) than the DCDA group (10%), with three seconds trimester miscarriages in the MCDA group. The live birth rates were lower in the MCDA versus DCDA group (40% vs. 90%). Among triplet pregnancies with a monochorionic component, the live birth rate was only 25%.

Conclusions: Monochorionic pregnancies following ART have poorer obstetric outcomes when compared to dichorionic pregnancies. For monochorionic pregnancies following ART, intensive antenatal surveillance at a tertiary level obstetric and neonatal center may help optimize the outcome.

No MeSH data available.


Related in: MedlinePlus

Ten monochorionic diamniotic pregnancies – An overview of the outcomes
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Figure 1: Ten monochorionic diamniotic pregnancies – An overview of the outcomes

Mentions: There were 10 MCDA pregnancies [Figure 1], which had resulted from four fresh cleavage stage transfers, three fresh blastocyst transfers and three frozen blastocyst transfers. Of these 10 MCDA pregnancies, six were twins and four were triplets (which included one MCDA twin component). Two MCDA pregnancies had resulted from a single embryo transfer.


Obstetric outcomes of monochorionic pregnancies conceived following assisted reproductive technology: A retrospective study.

Mascarenhas M, Kamath MS, Muthukumar K, Mangalaraj AM, Chandy A, Aleyamma T - J Hum Reprod Sci (2014)

Ten monochorionic diamniotic pregnancies – An overview of the outcomes
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150138&req=5

Figure 1: Ten monochorionic diamniotic pregnancies – An overview of the outcomes
Mentions: There were 10 MCDA pregnancies [Figure 1], which had resulted from four fresh cleavage stage transfers, three fresh blastocyst transfers and three frozen blastocyst transfers. Of these 10 MCDA pregnancies, six were twins and four were triplets (which included one MCDA twin component). Two MCDA pregnancies had resulted from a single embryo transfer.

Bottom Line: Among triplet pregnancies with a monochorionic component, the live birth rate was only 25%.Monochorionic pregnancies following ART have poorer obstetric outcomes when compared to dichorionic pregnancies.For monochorionic pregnancies following ART, intensive antenatal surveillance at a tertiary level obstetric and neonatal center may help optimize the outcome.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Unit, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

ABSTRACT

Objectives: The overwhelming numbers of twins following assisted reproductive technology (ART) are dichorionic twins, but monochorionic twins account for around 0.9% of post ART pregnancies. The data for post ART-monochorionic pregnancy outcomes are scarce due to the rarity of this condition. Hence, we evaluated the obstetric outcomes of monochorionic and dichorionic pregnancies conceived on ART.

Settings: University teaching hospital.

Study design: A case-control study of monochorionic diamniotic (MCDA) and dichorionic diamniotic (DCDA) pregnancies conceived following ART treatment. Charts of all women who conceived following ART from 2008 to 2013 were screened. Among them, the monochorionic twins diagnosed in the first trimester were included and their obstetric outcome was followed-up. For comparison, an equal number of dichorionic twin pregnancies from age and body mass index matched mothers was selected.

Results: The baseline clinical characteristics were similar between the two groups. MCDA group had a higher miscarriage rate (50%) than the DCDA group (10%), with three seconds trimester miscarriages in the MCDA group. The live birth rates were lower in the MCDA versus DCDA group (40% vs. 90%). Among triplet pregnancies with a monochorionic component, the live birth rate was only 25%.

Conclusions: Monochorionic pregnancies following ART have poorer obstetric outcomes when compared to dichorionic pregnancies. For monochorionic pregnancies following ART, intensive antenatal surveillance at a tertiary level obstetric and neonatal center may help optimize the outcome.

No MeSH data available.


Related in: MedlinePlus