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Fertility preservation outcomes may differ by cancer diagnosis.

Pavone ME, Hirshfeld-Cytron J, Lawson AK, Smith K, Kazer R, Klock S - J Hum Reprod Sci (2014)

Bottom Line: Kruskal-Wallis with subsequent Mann-Whitney U-test were used for data that were not normally distributed.Women with gynecologic malignancies were significantly older than the women in the other three groups, but tended to have a better ovarian response.Discussing these findings with patients presenting for FP may aid in setting realistic treatment expectations.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, US.

ABSTRACT

Context: Cancer survival has improved significantly and maintaining fertility is both a major concern and an important factor for the quality of life in cancer patients.

Aims: To explore differences in oocyte stimulation for fertility preservation (FP) patients based on cancer diagnosis.

Settings and deign: Between 2005 and 2011, 109 patients elected to pursue FP at a single institution.

Materials and method: In vitro fertilization (IVF) outcome variables between four cancer diagnostic groups (breast, gynecologic, lymphoma/leukemia and other) and age-matched male factor or tubal factor infertility IVF control group were compared.

Statistical analysis: ANOVA and Chi-square analyses were employed to compare variables between the groups that were normally distributed. Kruskal-Wallis with subsequent Mann-Whitney U-test were used for data that were not normally distributed.

Results: Women with gynecologic malignancies were significantly older than the women in the other three groups, but tended to have a better ovarian response. Women with hematologic malignancies were most likely to have been exposed to chemotherapy and had the longest stimulations with a similar number of oocytes retrieved. The age-matched IVF controls had higher peak estradiol levels, number of oocytes obtained, and fertilization rates when compared to cancer patients with or without a history of prior chemotherapy.

Conclusions: Factors including age, type of cancer and chemotherapy exposure, can influence response to ovarian stimulation. Discussing these findings with patients presenting for FP may aid in setting realistic treatment expectations.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of patients counseled regarding fertility preservation
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Figure 1: Flow diagram of patients counseled regarding fertility preservation

Mentions: Between 2005 and 2011, a total of 334 female patients contacted the FP patient navigator at a single institution. Of the 334 patients, 35 were medically ineligible 124 patients initially elected to pursue FP and are the focus of this study [Figure 1]. Of the 124 patients, 109 began a cycle of COH. Within this group, four were cancelled because of lack of response to gonadotropins and one patient chose to undergo both oocyte cryopreservation as well as OTC. During this same period, 176 age-matched pure male factor or tubal factor infertility controls undergoing their first IVF cycle using an antagonist protocol were identified.


Fertility preservation outcomes may differ by cancer diagnosis.

Pavone ME, Hirshfeld-Cytron J, Lawson AK, Smith K, Kazer R, Klock S - J Hum Reprod Sci (2014)

Flow diagram of patients counseled regarding fertility preservation
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150137&req=5

Figure 1: Flow diagram of patients counseled regarding fertility preservation
Mentions: Between 2005 and 2011, a total of 334 female patients contacted the FP patient navigator at a single institution. Of the 334 patients, 35 were medically ineligible 124 patients initially elected to pursue FP and are the focus of this study [Figure 1]. Of the 124 patients, 109 began a cycle of COH. Within this group, four were cancelled because of lack of response to gonadotropins and one patient chose to undergo both oocyte cryopreservation as well as OTC. During this same period, 176 age-matched pure male factor or tubal factor infertility controls undergoing their first IVF cycle using an antagonist protocol were identified.

Bottom Line: Kruskal-Wallis with subsequent Mann-Whitney U-test were used for data that were not normally distributed.Women with gynecologic malignancies were significantly older than the women in the other three groups, but tended to have a better ovarian response.Discussing these findings with patients presenting for FP may aid in setting realistic treatment expectations.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, US.

ABSTRACT

Context: Cancer survival has improved significantly and maintaining fertility is both a major concern and an important factor for the quality of life in cancer patients.

Aims: To explore differences in oocyte stimulation for fertility preservation (FP) patients based on cancer diagnosis.

Settings and deign: Between 2005 and 2011, 109 patients elected to pursue FP at a single institution.

Materials and method: In vitro fertilization (IVF) outcome variables between four cancer diagnostic groups (breast, gynecologic, lymphoma/leukemia and other) and age-matched male factor or tubal factor infertility IVF control group were compared.

Statistical analysis: ANOVA and Chi-square analyses were employed to compare variables between the groups that were normally distributed. Kruskal-Wallis with subsequent Mann-Whitney U-test were used for data that were not normally distributed.

Results: Women with gynecologic malignancies were significantly older than the women in the other three groups, but tended to have a better ovarian response. Women with hematologic malignancies were most likely to have been exposed to chemotherapy and had the longest stimulations with a similar number of oocytes retrieved. The age-matched IVF controls had higher peak estradiol levels, number of oocytes obtained, and fertilization rates when compared to cancer patients with or without a history of prior chemotherapy.

Conclusions: Factors including age, type of cancer and chemotherapy exposure, can influence response to ovarian stimulation. Discussing these findings with patients presenting for FP may aid in setting realistic treatment expectations.

No MeSH data available.


Related in: MedlinePlus