Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.
Bottom Line: Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls.There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p = 0.695).This finding was not associated with intracerebral hemorrhage.
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Mentions: Targeted in silico replication of the 12q24.12 region in INTERSTROKE and VISP strengthened the association, revealing a new top SNP at this locus (rs10744777, p = 7.12 × 10−11, odds ratio [OR] 1.10 [1.07–1.13]). A forest plot displaying results for all cohorts at rs10744777 is shown in figure 1A. The association was similar across all ischemic stroke subtypes as measured by effect size, with no evidence of subtype specificity (table 3).