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Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.

Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, Walters M, Worrall BB, Sale MM, Algra A, Kappelle LJ, Wijmenga C, Norrving B, Sandling JK, Rönnblom L, Goris A, Franke A, Sudlow C, Rothwell PM, Levi C, Holliday EG, Fornage M, Psaty B, Gretarsdottir S, Thorsteinsdottir U, Seshadri S, Mitchell BD, Kittner S, Clarke R, Hopewell JC, Bis JC, Boncoraglio GB, Meschia J, Ikram MA, Hansen BM, Montaner J, Thorleifsson G, Stefanson K, Rosand J, de Bakker PI, Farrall M, Dichgans M, Markus HS, Bevan S, GARNET Collaborative Research Group, Wellcome Trust Case Control Consortium 2, Australian Stroke Genetic Collaborative, the METASTROKE Consortium, and the International Stroke Genetics Consorti - Neurology (2014)

Bottom Line: Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls.There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p = 0.695).This finding was not associated with intracerebral hemorrhage.

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Forest plot of rs10744777Forest plot for rs10744777 in (A) all ischemic stroke cohorts and (B) intracerebral hemorrhage cohorts. IC = Immunochip; MS = METASTROKE; WT = Wellcome Trust Case Control Consortium 2 (WTCCC2).
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Figure 1: Forest plot of rs10744777Forest plot for rs10744777 in (A) all ischemic stroke cohorts and (B) intracerebral hemorrhage cohorts. IC = Immunochip; MS = METASTROKE; WT = Wellcome Trust Case Control Consortium 2 (WTCCC2).

Mentions: Targeted in silico replication of the 12q24.12 region in INTERSTROKE and VISP strengthened the association, revealing a new top SNP at this locus (rs10744777, p = 7.12 × 10−11, odds ratio [OR] 1.10 [1.07–1.13]). A forest plot displaying results for all cohorts at rs10744777 is shown in figure 1A. The association was similar across all ischemic stroke subtypes as measured by effect size, with no evidence of subtype specificity (table 3).


Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.

Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, Walters M, Worrall BB, Sale MM, Algra A, Kappelle LJ, Wijmenga C, Norrving B, Sandling JK, Rönnblom L, Goris A, Franke A, Sudlow C, Rothwell PM, Levi C, Holliday EG, Fornage M, Psaty B, Gretarsdottir S, Thorsteinsdottir U, Seshadri S, Mitchell BD, Kittner S, Clarke R, Hopewell JC, Bis JC, Boncoraglio GB, Meschia J, Ikram MA, Hansen BM, Montaner J, Thorleifsson G, Stefanson K, Rosand J, de Bakker PI, Farrall M, Dichgans M, Markus HS, Bevan S, GARNET Collaborative Research Group, Wellcome Trust Case Control Consortium 2, Australian Stroke Genetic Collaborative, the METASTROKE Consortium, and the International Stroke Genetics Consorti - Neurology (2014)

Forest plot of rs10744777Forest plot for rs10744777 in (A) all ischemic stroke cohorts and (B) intracerebral hemorrhage cohorts. IC = Immunochip; MS = METASTROKE; WT = Wellcome Trust Case Control Consortium 2 (WTCCC2).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4150131&req=5

Figure 1: Forest plot of rs10744777Forest plot for rs10744777 in (A) all ischemic stroke cohorts and (B) intracerebral hemorrhage cohorts. IC = Immunochip; MS = METASTROKE; WT = Wellcome Trust Case Control Consortium 2 (WTCCC2).
Mentions: Targeted in silico replication of the 12q24.12 region in INTERSTROKE and VISP strengthened the association, revealing a new top SNP at this locus (rs10744777, p = 7.12 × 10−11, odds ratio [OR] 1.10 [1.07–1.13]). A forest plot displaying results for all cohorts at rs10744777 is shown in figure 1A. The association was similar across all ischemic stroke subtypes as measured by effect size, with no evidence of subtype specificity (table 3).

Bottom Line: Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls.There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p = 0.695).This finding was not associated with intracerebral hemorrhage.

View Article: PubMed Central - PubMed

Show MeSH
Related in: MedlinePlus