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Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis.

Pang B, Cheng S, Sun SP, An C, Liu ZY, Feng X, Liu GJ - Sci Rep (2014)

Bottom Line: PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients.In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients.And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

View Article: PubMed Central - PubMed

Affiliation: Clinical laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixian Ge 5#, XiCheng District, Beijing 100053, China.

ABSTRACT
The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone receptor (PR) play pivotal roles in BCa. In this study, we evaluated the association between PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in particular, HR-positive BCa. Thirty-two studies involving 5719 cases of BCa obtained from database searches were examined. PIK3CA gene mutations correlated significantly with ER/PR expression (p < 0.00001) and relapse-free survival (RFS) (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.59-0.98, p = 0.03) but not overall survival (OS) (HR 1.14, 95%CI 0.72-1.82, p = 0.57) in unsorted BCa patients. PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients. In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients. However, the clinical implications of PIK3CA mutations may vary according to different mutant exons. And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

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Forest plots of the analysis on the hazard ratio of OS (a) and RFS (b) in HR+ BCa patients.
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f6: Forest plots of the analysis on the hazard ratio of OS (a) and RFS (b) in HR+ BCa patients.

Mentions: The relationship between PIK3CA mutations and prognosis in HR+ BCa was evaluated in 8 studies involving 1021 patients, 5 studies (644 patients) for OS and 4 studies (534 patients) for RFS (group C) (Table 3). On the basis of the available data, kinase domain mutation is the priority for inclusion and analysis. No inter-study heterogeneity was found for OS (P = 0.38; I2 = 4%) or RFS (P = 0.73; I2 = 0%). PIK3CA gene mutations were not significantly associated with OS (hazard ratio 1.06, 95% CI 0.67–1.67; P = 0.81) (Fig. 6a) or RFS (hazard ratio 0.86, 95% CI 0.53–1.40; P = 0.55) (Fig. 6b) in HR+ BCa patients.


Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis.

Pang B, Cheng S, Sun SP, An C, Liu ZY, Feng X, Liu GJ - Sci Rep (2014)

Forest plots of the analysis on the hazard ratio of OS (a) and RFS (b) in HR+ BCa patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150110&req=5

f6: Forest plots of the analysis on the hazard ratio of OS (a) and RFS (b) in HR+ BCa patients.
Mentions: The relationship between PIK3CA mutations and prognosis in HR+ BCa was evaluated in 8 studies involving 1021 patients, 5 studies (644 patients) for OS and 4 studies (534 patients) for RFS (group C) (Table 3). On the basis of the available data, kinase domain mutation is the priority for inclusion and analysis. No inter-study heterogeneity was found for OS (P = 0.38; I2 = 4%) or RFS (P = 0.73; I2 = 0%). PIK3CA gene mutations were not significantly associated with OS (hazard ratio 1.06, 95% CI 0.67–1.67; P = 0.81) (Fig. 6a) or RFS (hazard ratio 0.86, 95% CI 0.53–1.40; P = 0.55) (Fig. 6b) in HR+ BCa patients.

Bottom Line: PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients.In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients.And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

View Article: PubMed Central - PubMed

Affiliation: Clinical laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixian Ge 5#, XiCheng District, Beijing 100053, China.

ABSTRACT
The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone receptor (PR) play pivotal roles in BCa. In this study, we evaluated the association between PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in particular, HR-positive BCa. Thirty-two studies involving 5719 cases of BCa obtained from database searches were examined. PIK3CA gene mutations correlated significantly with ER/PR expression (p < 0.00001) and relapse-free survival (RFS) (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.59-0.98, p = 0.03) but not overall survival (OS) (HR 1.14, 95%CI 0.72-1.82, p = 0.57) in unsorted BCa patients. PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients. In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients. However, the clinical implications of PIK3CA mutations may vary according to different mutant exons. And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

Show MeSH
Related in: MedlinePlus