Limits...
Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis.

Pang B, Cheng S, Sun SP, An C, Liu ZY, Feng X, Liu GJ - Sci Rep (2014)

Bottom Line: PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients.In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients.And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

View Article: PubMed Central - PubMed

Affiliation: Clinical laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixian Ge 5#, XiCheng District, Beijing 100053, China.

ABSTRACT
The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone receptor (PR) play pivotal roles in BCa. In this study, we evaluated the association between PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in particular, HR-positive BCa. Thirty-two studies involving 5719 cases of BCa obtained from database searches were examined. PIK3CA gene mutations correlated significantly with ER/PR expression (p < 0.00001) and relapse-free survival (RFS) (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.59-0.98, p = 0.03) but not overall survival (OS) (HR 1.14, 95%CI 0.72-1.82, p = 0.57) in unsorted BCa patients. PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients. In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients. However, the clinical implications of PIK3CA mutations may vary according to different mutant exons. And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

Show MeSH

Related in: MedlinePlus

Forest plots of the analysis on the HR of OS in BCa patients.Subgroups are introduced for evaluating exon 9 or 20 mutations.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4150110&req=5

f4: Forest plots of the analysis on the HR of OS in BCa patients.Subgroups are introduced for evaluating exon 9 or 20 mutations.

Mentions: Analyses were conducted to evaluate the relationship between PIK3CA gene mutations and prognosis as defined by overall survival (OS) and relapse-free survival (RFS) in all BCa patients (group B) (Table 2). Because of significant heterogeneity among the group B studies for OS (P = 0.008; I2 = 66%), a random-effect model was used to assess OS correlations. However, because there was no inter-study heterogeneity among the group B studies for RFS (P = 0.93; I2 = 0%), a fixed-effect model was used to assess RFS correlations. For OS, 7 studies involving 2105 patients were analyzed and no significant association between PIK3CA mutations and OS was found (HR 1.14, 95% CI 0.72–1.82; P = 0.57) (Figure 4). We also performed analysis for different exons. For exon 9 mutations, a significant worse OS was found (HR 1.42, 95% CI 1.02–1.99; P = 0.04). In addition, for exon 20, the results of OS did not reach a significant level (HR 1.63, 95% CI 0.93–2.85; P = 0.09) (Figure 4). For RFS, 5 studies involving 1913 patients were analyzed, and a significant relationship between PIK3CA gene mutations and prolonged RFS was observed (hazard ratio 0.76, 95% CI 0.59–0.98; P = 0.03) (Fig. 5).


Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis.

Pang B, Cheng S, Sun SP, An C, Liu ZY, Feng X, Liu GJ - Sci Rep (2014)

Forest plots of the analysis on the HR of OS in BCa patients.Subgroups are introduced for evaluating exon 9 or 20 mutations.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150110&req=5

f4: Forest plots of the analysis on the HR of OS in BCa patients.Subgroups are introduced for evaluating exon 9 or 20 mutations.
Mentions: Analyses were conducted to evaluate the relationship between PIK3CA gene mutations and prognosis as defined by overall survival (OS) and relapse-free survival (RFS) in all BCa patients (group B) (Table 2). Because of significant heterogeneity among the group B studies for OS (P = 0.008; I2 = 66%), a random-effect model was used to assess OS correlations. However, because there was no inter-study heterogeneity among the group B studies for RFS (P = 0.93; I2 = 0%), a fixed-effect model was used to assess RFS correlations. For OS, 7 studies involving 2105 patients were analyzed and no significant association between PIK3CA mutations and OS was found (HR 1.14, 95% CI 0.72–1.82; P = 0.57) (Figure 4). We also performed analysis for different exons. For exon 9 mutations, a significant worse OS was found (HR 1.42, 95% CI 1.02–1.99; P = 0.04). In addition, for exon 20, the results of OS did not reach a significant level (HR 1.63, 95% CI 0.93–2.85; P = 0.09) (Figure 4). For RFS, 5 studies involving 1913 patients were analyzed, and a significant relationship between PIK3CA gene mutations and prolonged RFS was observed (hazard ratio 0.76, 95% CI 0.59–0.98; P = 0.03) (Fig. 5).

Bottom Line: PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients.In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients.And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

View Article: PubMed Central - PubMed

Affiliation: Clinical laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixian Ge 5#, XiCheng District, Beijing 100053, China.

ABSTRACT
The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone receptor (PR) play pivotal roles in BCa. In this study, we evaluated the association between PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in particular, HR-positive BCa. Thirty-two studies involving 5719 cases of BCa obtained from database searches were examined. PIK3CA gene mutations correlated significantly with ER/PR expression (p < 0.00001) and relapse-free survival (RFS) (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.59-0.98, p = 0.03) but not overall survival (OS) (HR 1.14, 95%CI 0.72-1.82, p = 0.57) in unsorted BCa patients. PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients. In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients. However, the clinical implications of PIK3CA mutations may vary according to different mutant exons. And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

Show MeSH
Related in: MedlinePlus