Limits...
Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis.

Pang B, Cheng S, Sun SP, An C, Liu ZY, Feng X, Liu GJ - Sci Rep (2014)

Bottom Line: PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients.In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients.And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

View Article: PubMed Central - PubMed

Affiliation: Clinical laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixian Ge 5#, XiCheng District, Beijing 100053, China.

ABSTRACT
The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone receptor (PR) play pivotal roles in BCa. In this study, we evaluated the association between PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in particular, HR-positive BCa. Thirty-two studies involving 5719 cases of BCa obtained from database searches were examined. PIK3CA gene mutations correlated significantly with ER/PR expression (p < 0.00001) and relapse-free survival (RFS) (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.59-0.98, p = 0.03) but not overall survival (OS) (HR 1.14, 95%CI 0.72-1.82, p = 0.57) in unsorted BCa patients. PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients. In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients. However, the clinical implications of PIK3CA mutations may vary according to different mutant exons. And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

Show MeSH

Related in: MedlinePlus

Summary flowchart of the literature search.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4150110&req=5

f1: Summary flowchart of the literature search.

Mentions: A total of 1903 potentially relevant citations were retrieved. After exclusion of nonhuman studies, reviews, and duplicates, two authors independently perused the titles and abstracts of the articles. After screenings, 68 articles were chosen for further full-text review. Ultimately, 32 eligible studies were included in our meta-analysis59101112131415161718192021222324252627282930313233343536373839 (Figure 1).


Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis.

Pang B, Cheng S, Sun SP, An C, Liu ZY, Feng X, Liu GJ - Sci Rep (2014)

Summary flowchart of the literature search.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150110&req=5

f1: Summary flowchart of the literature search.
Mentions: A total of 1903 potentially relevant citations were retrieved. After exclusion of nonhuman studies, reviews, and duplicates, two authors independently perused the titles and abstracts of the articles. After screenings, 68 articles were chosen for further full-text review. Ultimately, 32 eligible studies were included in our meta-analysis59101112131415161718192021222324252627282930313233343536373839 (Figure 1).

Bottom Line: PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients.In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients.And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

View Article: PubMed Central - PubMed

Affiliation: Clinical laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixian Ge 5#, XiCheng District, Beijing 100053, China.

ABSTRACT
The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone receptor (PR) play pivotal roles in BCa. In this study, we evaluated the association between PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in particular, HR-positive BCa. Thirty-two studies involving 5719 cases of BCa obtained from database searches were examined. PIK3CA gene mutations correlated significantly with ER/PR expression (p < 0.00001) and relapse-free survival (RFS) (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.59-0.98, p = 0.03) but not overall survival (OS) (HR 1.14, 95%CI 0.72-1.82, p = 0.57) in unsorted BCa patients. PIK3CA mutations were not associated with OS (HR 1.06, 95%CI 0.67-1.67, p = 0.81) or RFS (HR 0.86, 95%CI 0.53-1.40, p = 0.55) in HR-positive BCa patients. In conclusion, PIK3CA mutations were significantly related to ER/PR expression and RFS in unsorted BCa patients. However, the clinical implications of PIK3CA mutations may vary according to different mutant exons. And PIK3CA mutations alone may have limited prognostic value for HR-positive BCa patients.

Show MeSH
Related in: MedlinePlus