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Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis.

Xie ZK, Huang QP, Huang J, Xie ZF - Sci Rep (2014)

Bottom Line: Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association.LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively).Further studies should be performed in other ethnic groups besides East Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Clinical Medicine, Grade 2011, Guangxi Medical University, Nanning, China [2].

ABSTRACT
The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a meta-analysis to address this issue. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (-511), (-31), (+3954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers of the IL1B (-511) polymorphism and the C allele carriers of the IL1B (-31) variant were associated with an increased risk for developing COPD in East Asians (OR = 1.61, 95% CI: 1.13-2.31, Pz = 0.009 and OR = 1.55, 95% CI: 1.14-2.11, Pz = 0.006, respectively). The meta-analysis revealed a significant association between the IL1RN (VNTR) polymorphism and COPD risk in all study subjects and East Asians under homozygote model (22 vs. LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively). Our meta-analysis suggests that the IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. There is no association between the IL1B (+3954) polymorphism and COPD risk. Further studies should be performed in other ethnic groups besides East Asians.

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Begg's funnel plot for the IL1B (-511) polymorphism and COPD risk.
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f5: Begg's funnel plot for the IL1B (-511) polymorphism and COPD risk.

Mentions: Since publication bias was hard to detect when the number of studies were small, we selected the IL1B (−511) polymorphism to assess publication bias (nine studies included). The shape of the funnel plot seemed symmetrical (Fig. 5). Both Begg's test and Egger's test suggested no evidence of publication bias (P = 1.000 and P = 0.865, respectively).


Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis.

Xie ZK, Huang QP, Huang J, Xie ZF - Sci Rep (2014)

Begg's funnel plot for the IL1B (-511) polymorphism and COPD risk.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150103&req=5

f5: Begg's funnel plot for the IL1B (-511) polymorphism and COPD risk.
Mentions: Since publication bias was hard to detect when the number of studies were small, we selected the IL1B (−511) polymorphism to assess publication bias (nine studies included). The shape of the funnel plot seemed symmetrical (Fig. 5). Both Begg's test and Egger's test suggested no evidence of publication bias (P = 1.000 and P = 0.865, respectively).

Bottom Line: Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association.LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively).Further studies should be performed in other ethnic groups besides East Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Clinical Medicine, Grade 2011, Guangxi Medical University, Nanning, China [2].

ABSTRACT
The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a meta-analysis to address this issue. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (-511), (-31), (+3954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers of the IL1B (-511) polymorphism and the C allele carriers of the IL1B (-31) variant were associated with an increased risk for developing COPD in East Asians (OR = 1.61, 95% CI: 1.13-2.31, Pz = 0.009 and OR = 1.55, 95% CI: 1.14-2.11, Pz = 0.006, respectively). The meta-analysis revealed a significant association between the IL1RN (VNTR) polymorphism and COPD risk in all study subjects and East Asians under homozygote model (22 vs. LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively). Our meta-analysis suggests that the IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. There is no association between the IL1B (+3954) polymorphism and COPD risk. Further studies should be performed in other ethnic groups besides East Asians.

Show MeSH
Related in: MedlinePlus