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Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis.

Xie ZK, Huang QP, Huang J, Xie ZF - Sci Rep (2014)

Bottom Line: Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association.LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively).Further studies should be performed in other ethnic groups besides East Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Clinical Medicine, Grade 2011, Guangxi Medical University, Nanning, China [2].

ABSTRACT
The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a meta-analysis to address this issue. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (-511), (-31), (+3954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers of the IL1B (-511) polymorphism and the C allele carriers of the IL1B (-31) variant were associated with an increased risk for developing COPD in East Asians (OR = 1.61, 95% CI: 1.13-2.31, Pz = 0.009 and OR = 1.55, 95% CI: 1.14-2.11, Pz = 0.006, respectively). The meta-analysis revealed a significant association between the IL1RN (VNTR) polymorphism and COPD risk in all study subjects and East Asians under homozygote model (22 vs. LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively). Our meta-analysis suggests that the IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. There is no association between the IL1B (+3954) polymorphism and COPD risk. Further studies should be performed in other ethnic groups besides East Asians.

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Related in: MedlinePlus

Meta-analysis for the association between the IL1B (-31) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.
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f3: Meta-analysis for the association between the IL1B (-31) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.

Mentions: For the IL1B (−31) polymorphism, four studies from three publications with 534 cases and 632 controls were included in the meta-analysis121516. Pooling data provided no evidence of a relationship between this polymorphism and COPD risk in all study subjects in dominant model (OR = 1.25, 95% CI: 0.79–1.96, Ph = 0.101, Pz = 0.340) (Table 3 and Fig. 3), recessive model (OR = 0.80, 95% CI: 0.52–1.21, Ph = 0.225, Pz = 0.287) (Table 3) and homozygote model (OR = 1.00, 95% CI: 0.52–1.95, Ph = 0.065, Pz = 0.993) (Table 3). However, in subgroup analysis based on ethnicity, we found a significant association between this SNP and COPD risk in East Asians in dominant model (OR = 1.55, 95% CI: 1.14–2.11, Ph = 0.842, Pz = 0.006) (Table 3 and Fig. 3), but not in recessive model (OR = 0.87, 95% CI: 0.64–1.18, Ph = 0.469, Pz = 0.356) (Table 3) and homozygote model (OR = 1.27, 95% CI: 0.87–1.87, Ph = 0.599, Pz = 0.221) (Table 3). Between-study heterogeneity was found for the genotype-wise OR in homozygote model (P = 0.065) (Table 3).


Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis.

Xie ZK, Huang QP, Huang J, Xie ZF - Sci Rep (2014)

Meta-analysis for the association between the IL1B (-31) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150103&req=5

f3: Meta-analysis for the association between the IL1B (-31) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.
Mentions: For the IL1B (−31) polymorphism, four studies from three publications with 534 cases and 632 controls were included in the meta-analysis121516. Pooling data provided no evidence of a relationship between this polymorphism and COPD risk in all study subjects in dominant model (OR = 1.25, 95% CI: 0.79–1.96, Ph = 0.101, Pz = 0.340) (Table 3 and Fig. 3), recessive model (OR = 0.80, 95% CI: 0.52–1.21, Ph = 0.225, Pz = 0.287) (Table 3) and homozygote model (OR = 1.00, 95% CI: 0.52–1.95, Ph = 0.065, Pz = 0.993) (Table 3). However, in subgroup analysis based on ethnicity, we found a significant association between this SNP and COPD risk in East Asians in dominant model (OR = 1.55, 95% CI: 1.14–2.11, Ph = 0.842, Pz = 0.006) (Table 3 and Fig. 3), but not in recessive model (OR = 0.87, 95% CI: 0.64–1.18, Ph = 0.469, Pz = 0.356) (Table 3) and homozygote model (OR = 1.27, 95% CI: 0.87–1.87, Ph = 0.599, Pz = 0.221) (Table 3). Between-study heterogeneity was found for the genotype-wise OR in homozygote model (P = 0.065) (Table 3).

Bottom Line: Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association.LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively).Further studies should be performed in other ethnic groups besides East Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Clinical Medicine, Grade 2011, Guangxi Medical University, Nanning, China [2].

ABSTRACT
The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a meta-analysis to address this issue. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (-511), (-31), (+3954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers of the IL1B (-511) polymorphism and the C allele carriers of the IL1B (-31) variant were associated with an increased risk for developing COPD in East Asians (OR = 1.61, 95% CI: 1.13-2.31, Pz = 0.009 and OR = 1.55, 95% CI: 1.14-2.11, Pz = 0.006, respectively). The meta-analysis revealed a significant association between the IL1RN (VNTR) polymorphism and COPD risk in all study subjects and East Asians under homozygote model (22 vs. LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively). Our meta-analysis suggests that the IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. There is no association between the IL1B (+3954) polymorphism and COPD risk. Further studies should be performed in other ethnic groups besides East Asians.

Show MeSH
Related in: MedlinePlus