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Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis.

Xie ZK, Huang QP, Huang J, Xie ZF - Sci Rep (2014)

Bottom Line: Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association.LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively).Further studies should be performed in other ethnic groups besides East Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Clinical Medicine, Grade 2011, Guangxi Medical University, Nanning, China [2].

ABSTRACT
The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a meta-analysis to address this issue. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (-511), (-31), (+3954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers of the IL1B (-511) polymorphism and the C allele carriers of the IL1B (-31) variant were associated with an increased risk for developing COPD in East Asians (OR = 1.61, 95% CI: 1.13-2.31, Pz = 0.009 and OR = 1.55, 95% CI: 1.14-2.11, Pz = 0.006, respectively). The meta-analysis revealed a significant association between the IL1RN (VNTR) polymorphism and COPD risk in all study subjects and East Asians under homozygote model (22 vs. LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively). Our meta-analysis suggests that the IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. There is no association between the IL1B (+3954) polymorphism and COPD risk. Further studies should be performed in other ethnic groups besides East Asians.

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Meta-analysis for the association between the IL1B (-511) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.
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f2: Meta-analysis for the association between the IL1B (-511) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.

Mentions: For the IL1B(−511) polymorphism, nine studies from eight publications with 1270 cases and 1220 controls were included in the meta-analysis1112131416181920. There was no significant association between the IL1B(−511) polymorphism and COPD risk in all study subjects under dominant model (OR = 1.22, 95% CI: 0.84–1.75, Ph = 0.002, Pz = 0.293) (Table 3 and Fig. 2), recessive model (OR = 0.94, 95% CI: 0.67–1.32, Ph = 0.010, Pz = 0.730) (Table 3), and homozygote model (OR = 1.10, 95% CI: 0.65–1.85, Ph<0.001, Pz = 0.734) (Table 3). In subgroup analysis stratified by ethnicity, we found that the IL1B(−511) polymorphism was associated with COPD risk in East Asians under dominant model (OR = 1.61, 95% CI: 1.13–2.31, Ph = 0.061, Pz = 0.009) (Table 3 and Fig. 2), but not under recessive model (OR = 1.13, 95% CI: 0.74–1.73, Ph = 0.017, Pz = 0.574) (Table 3) and homozygote model (OR = 1.62, 95% CI: 0.91–2.88, Ph = 0.005, Pz = 0.105) (Table 3). Since there was only one study performed in Arabians, Europeans and South Asians, respectively, we did not conduct subgroup analysis in these ethnic groups. Between-study heterogeneity for the genotype-wise ORs was found in dominant model (P = 0.002) (Table 3), recessive model (P = 0.010) (Table 3), and homozygote model (P<0.001) (Table 3).


Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis.

Xie ZK, Huang QP, Huang J, Xie ZF - Sci Rep (2014)

Meta-analysis for the association between the IL1B (-511) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150103&req=5

f2: Meta-analysis for the association between the IL1B (-511) polymorphism and COPD risk in dominant model.Each study is shown by the point estimate of the odds ratio, and a horizontal line denotes the 95% confidence interval. The pooled odds ratio is represented by a diamond. The area of the grey squares reflects the weight of the study in the meta-analysis.
Mentions: For the IL1B(−511) polymorphism, nine studies from eight publications with 1270 cases and 1220 controls were included in the meta-analysis1112131416181920. There was no significant association between the IL1B(−511) polymorphism and COPD risk in all study subjects under dominant model (OR = 1.22, 95% CI: 0.84–1.75, Ph = 0.002, Pz = 0.293) (Table 3 and Fig. 2), recessive model (OR = 0.94, 95% CI: 0.67–1.32, Ph = 0.010, Pz = 0.730) (Table 3), and homozygote model (OR = 1.10, 95% CI: 0.65–1.85, Ph<0.001, Pz = 0.734) (Table 3). In subgroup analysis stratified by ethnicity, we found that the IL1B(−511) polymorphism was associated with COPD risk in East Asians under dominant model (OR = 1.61, 95% CI: 1.13–2.31, Ph = 0.061, Pz = 0.009) (Table 3 and Fig. 2), but not under recessive model (OR = 1.13, 95% CI: 0.74–1.73, Ph = 0.017, Pz = 0.574) (Table 3) and homozygote model (OR = 1.62, 95% CI: 0.91–2.88, Ph = 0.005, Pz = 0.105) (Table 3). Since there was only one study performed in Arabians, Europeans and South Asians, respectively, we did not conduct subgroup analysis in these ethnic groups. Between-study heterogeneity for the genotype-wise ORs was found in dominant model (P = 0.002) (Table 3), recessive model (P = 0.010) (Table 3), and homozygote model (P<0.001) (Table 3).

Bottom Line: Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association.LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively).Further studies should be performed in other ethnic groups besides East Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Clinical Medicine, Grade 2011, Guangxi Medical University, Nanning, China [2].

ABSTRACT
The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to conduct a meta-analysis to address this issue. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association. The meta-analysis revealed no association between the IL1B (-511), (-31), (+3954) polymorphisms and COPD risk. However, stratification by ethnicity indicated that the T allele carriers of the IL1B (-511) polymorphism and the C allele carriers of the IL1B (-31) variant were associated with an increased risk for developing COPD in East Asians (OR = 1.61, 95% CI: 1.13-2.31, Pz = 0.009 and OR = 1.55, 95% CI: 1.14-2.11, Pz = 0.006, respectively). The meta-analysis revealed a significant association between the IL1RN (VNTR) polymorphism and COPD risk in all study subjects and East Asians under homozygote model (22 vs. LL: OR = 3.16, 95% CI: 1.23-8.13, Pz = 0.017 and OR = 3.20, 95% CI: 1.13-9.12, Pz = 0.029, respectively). Our meta-analysis suggests that the IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. There is no association between the IL1B (+3954) polymorphism and COPD risk. Further studies should be performed in other ethnic groups besides East Asians.

Show MeSH
Related in: MedlinePlus