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Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.

Eastwood SV, Tillin T, Wright A, Mayet J, Godsland I, Forouhi NG, Whincup P, Hughes AD, Chaturvedi N - Obesity (Silver Spring) (2014)

Bottom Line: Accounting for body size, South Asians had greater VAT and TSAT than Europeans, but less thigh muscle.Insulin resistance did not account for the effects of TSAT or thigh muscle.Effects of TSAT and thigh muscle were independent of insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: National Heart and Lung Institute, Imperial College London, London, UK.

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Related in: MedlinePlus

Associations between body composition measures and cardiometabolic risk by ethnicity: (a) Diabetes, (b) HbA1c, (c) Clinical + subclinical CHD, and (d) CRP.OR/standardized β for a 1SD increase of independent variables, adjusted for age and sex, 95% confidence intervals indicated by vertical lines, *ethnicity/ body composition measure interaction P < 0.05,VAT, abdominal visceral adipose tissue; DSAT, abdominal deep subcutaneous adipose tissue; SSAT, abdominal superficial subcutaneous adipose tissue; TSAT, thigh subcutaneous adipose tissue; TIMAT, thigh intermuscular adipose tissue; LAM, low attenuation muscle.HbA1c,CRP,VAT, DSAT, SSAT, TSAT, TIMAT, LAM log-transformed.
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fig01: Associations between body composition measures and cardiometabolic risk by ethnicity: (a) Diabetes, (b) HbA1c, (c) Clinical + subclinical CHD, and (d) CRP.OR/standardized β for a 1SD increase of independent variables, adjusted for age and sex, 95% confidence intervals indicated by vertical lines, *ethnicity/ body composition measure interaction P < 0.05,VAT, abdominal visceral adipose tissue; DSAT, abdominal deep subcutaneous adipose tissue; SSAT, abdominal superficial subcutaneous adipose tissue; TSAT, thigh subcutaneous adipose tissue; TIMAT, thigh intermuscular adipose tissue; LAM, low attenuation muscle.HbA1c,CRP,VAT, DSAT, SSAT, TSAT, TIMAT, LAM log-transformed.

Mentions: Taken separately, fat depots were positively associated with cardiometabolic risk factors (Figure 1), with VAT generally showing the strongest associations. Thigh muscle area was negatively associated with all cardiometabolic traits, significantly so in South Asians for diabetes, HbA1c, and clinical and subclinical CHD.


Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.

Eastwood SV, Tillin T, Wright A, Mayet J, Godsland I, Forouhi NG, Whincup P, Hughes AD, Chaturvedi N - Obesity (Silver Spring) (2014)

Associations between body composition measures and cardiometabolic risk by ethnicity: (a) Diabetes, (b) HbA1c, (c) Clinical + subclinical CHD, and (d) CRP.OR/standardized β for a 1SD increase of independent variables, adjusted for age and sex, 95% confidence intervals indicated by vertical lines, *ethnicity/ body composition measure interaction P < 0.05,VAT, abdominal visceral adipose tissue; DSAT, abdominal deep subcutaneous adipose tissue; SSAT, abdominal superficial subcutaneous adipose tissue; TSAT, thigh subcutaneous adipose tissue; TIMAT, thigh intermuscular adipose tissue; LAM, low attenuation muscle.HbA1c,CRP,VAT, DSAT, SSAT, TSAT, TIMAT, LAM log-transformed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150020&req=5

fig01: Associations between body composition measures and cardiometabolic risk by ethnicity: (a) Diabetes, (b) HbA1c, (c) Clinical + subclinical CHD, and (d) CRP.OR/standardized β for a 1SD increase of independent variables, adjusted for age and sex, 95% confidence intervals indicated by vertical lines, *ethnicity/ body composition measure interaction P < 0.05,VAT, abdominal visceral adipose tissue; DSAT, abdominal deep subcutaneous adipose tissue; SSAT, abdominal superficial subcutaneous adipose tissue; TSAT, thigh subcutaneous adipose tissue; TIMAT, thigh intermuscular adipose tissue; LAM, low attenuation muscle.HbA1c,CRP,VAT, DSAT, SSAT, TSAT, TIMAT, LAM log-transformed.
Mentions: Taken separately, fat depots were positively associated with cardiometabolic risk factors (Figure 1), with VAT generally showing the strongest associations. Thigh muscle area was negatively associated with all cardiometabolic traits, significantly so in South Asians for diabetes, HbA1c, and clinical and subclinical CHD.

Bottom Line: Accounting for body size, South Asians had greater VAT and TSAT than Europeans, but less thigh muscle.Insulin resistance did not account for the effects of TSAT or thigh muscle.Effects of TSAT and thigh muscle were independent of insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: National Heart and Lung Institute, Imperial College London, London, UK.

Show MeSH
Related in: MedlinePlus