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Association of glycemic status with impaired lung function among recipients of a health screening program: a cross-sectional study in Japanese adults.

Kabeya Y, Kato K, Tomita M, Katsuki T, Oikawa Y, Shimada A - J Epidemiol (2014)

Bottom Line: A 1% absolute increase in HbA1c was associated with a -52-mL (95% confidence interval [CI] -111 to 8 mL) difference in FVC and a -25-mL (95% CI -75 to 25 mL) difference in FEV1 in women, and a -128-mL (95% CI -163 to -94 mL) difference in FVC and a -73-mL (95% CI -101 to -44 mL) difference in FEV1 in men.A 10-mg/dL increase in FPG was associated with a -11-mL (95% CI -29 to 8 mL) difference in FVC and a -8-mL (95% CI -24 to 7 mL) difference in FEV1 in women, and a -32-mL (95% CI -44 to -21 mL) difference in FVC and a -19-mL (95% CI -28 to -9 mL) difference in FEV1 in men.Men seem more susceptible to the alteration in FVC and FEV1 than women.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Saiseikai Central Hospital.

ABSTRACT

Background: The dose-response relationship between glycemic status and lung function has not been thoroughly investigated. We hypothesized that there are continuous and inverse associations between glycemic measures and lung function tests and examined the hypothesis in Japanese adults.

Methods: We cross-sectionally investigated associations of hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) with forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) in 3161 adults who participated in a health screening from 2008 to 2011. The study participants included both diabetic and non-diabetic adults. Multiple linear regression analyses were performed to examine the associations.

Results: Inverse associations were observed in both sexes, which were attenuated in women after adjustment for multiple variables. A 1% absolute increase in HbA1c was associated with a -52-mL (95% confidence interval [CI] -111 to 8 mL) difference in FVC and a -25-mL (95% CI -75 to 25 mL) difference in FEV1 in women, and a -128-mL (95% CI -163 to -94 mL) difference in FVC and a -73-mL (95% CI -101 to -44 mL) difference in FEV1 in men. A 10-mg/dL increase in FPG was associated with a -11-mL (95% CI -29 to 8 mL) difference in FVC and a -8-mL (95% CI -24 to 7 mL) difference in FEV1 in women, and a -32-mL (95% CI -44 to -21 mL) difference in FVC and a -19-mL (95% CI -28 to -9 mL) difference in FEV1 in men.

Conclusions: Inverse associations between glycemic measures and lung function were observed. Men seem more susceptible to the alteration in FVC and FEV1 than women.

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Related in: MedlinePlus

Regression analyses of FVC in relation to glycemic measures.
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fig01a: Regression analyses of FVC in relation to glycemic measures.

Mentions: The associations of glycemic measures with FVC and FEV1 are given in Figure 1a and Figure 1b. Inverse associations were graphically observed in both sexes. In the linear regression analyses (Table 3), a 1% absolute increase in HbA1c was associated with a −297-mL (95% confidence interval [CI] −364 to −231 mL) difference in FVC in women and a −287-mL (95% CI −328 to −246 mL) difference in men. A 10-mg/dL increase in FPG was associated with a −67-mL (95% CI −89 to −46 mL) difference in FVC in women and a −73-mL (95% CI −87 to −59 mL) difference in men. However, in the multivariable-adjusted models, the values were attenuated in both sexes and became non-significant in women. A 1% absolute increase in HbA1c was associated with a −52-mL (95% CI −111 to 8 mL) difference in FVC in women and a −128-mL (95% CI −163 to −94 mL) difference in men. A 10-mg/dL increase in FPG was associated with a −11-mL (95% CI −29 to 8 mL) difference in FVC in women and a −32-mL (95% CI −44 to −21 mL) difference in men. When diabetes was analyzed as a categorical variable, the multivariable-adjusted model showed that the presence of diabetes was associated with a non-significant −74-mL (95% CI −182 to 33 mL) difference in FVC in women and a significant −208-mL (95% CI −270 to −147 mL) difference in men.


Association of glycemic status with impaired lung function among recipients of a health screening program: a cross-sectional study in Japanese adults.

Kabeya Y, Kato K, Tomita M, Katsuki T, Oikawa Y, Shimada A - J Epidemiol (2014)

Regression analyses of FVC in relation to glycemic measures.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4150013&req=5

fig01a: Regression analyses of FVC in relation to glycemic measures.
Mentions: The associations of glycemic measures with FVC and FEV1 are given in Figure 1a and Figure 1b. Inverse associations were graphically observed in both sexes. In the linear regression analyses (Table 3), a 1% absolute increase in HbA1c was associated with a −297-mL (95% confidence interval [CI] −364 to −231 mL) difference in FVC in women and a −287-mL (95% CI −328 to −246 mL) difference in men. A 10-mg/dL increase in FPG was associated with a −67-mL (95% CI −89 to −46 mL) difference in FVC in women and a −73-mL (95% CI −87 to −59 mL) difference in men. However, in the multivariable-adjusted models, the values were attenuated in both sexes and became non-significant in women. A 1% absolute increase in HbA1c was associated with a −52-mL (95% CI −111 to 8 mL) difference in FVC in women and a −128-mL (95% CI −163 to −94 mL) difference in men. A 10-mg/dL increase in FPG was associated with a −11-mL (95% CI −29 to 8 mL) difference in FVC in women and a −32-mL (95% CI −44 to −21 mL) difference in men. When diabetes was analyzed as a categorical variable, the multivariable-adjusted model showed that the presence of diabetes was associated with a non-significant −74-mL (95% CI −182 to 33 mL) difference in FVC in women and a significant −208-mL (95% CI −270 to −147 mL) difference in men.

Bottom Line: A 1% absolute increase in HbA1c was associated with a -52-mL (95% confidence interval [CI] -111 to 8 mL) difference in FVC and a -25-mL (95% CI -75 to 25 mL) difference in FEV1 in women, and a -128-mL (95% CI -163 to -94 mL) difference in FVC and a -73-mL (95% CI -101 to -44 mL) difference in FEV1 in men.A 10-mg/dL increase in FPG was associated with a -11-mL (95% CI -29 to 8 mL) difference in FVC and a -8-mL (95% CI -24 to 7 mL) difference in FEV1 in women, and a -32-mL (95% CI -44 to -21 mL) difference in FVC and a -19-mL (95% CI -28 to -9 mL) difference in FEV1 in men.Men seem more susceptible to the alteration in FVC and FEV1 than women.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Saiseikai Central Hospital.

ABSTRACT

Background: The dose-response relationship between glycemic status and lung function has not been thoroughly investigated. We hypothesized that there are continuous and inverse associations between glycemic measures and lung function tests and examined the hypothesis in Japanese adults.

Methods: We cross-sectionally investigated associations of hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) with forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) in 3161 adults who participated in a health screening from 2008 to 2011. The study participants included both diabetic and non-diabetic adults. Multiple linear regression analyses were performed to examine the associations.

Results: Inverse associations were observed in both sexes, which were attenuated in women after adjustment for multiple variables. A 1% absolute increase in HbA1c was associated with a -52-mL (95% confidence interval [CI] -111 to 8 mL) difference in FVC and a -25-mL (95% CI -75 to 25 mL) difference in FEV1 in women, and a -128-mL (95% CI -163 to -94 mL) difference in FVC and a -73-mL (95% CI -101 to -44 mL) difference in FEV1 in men. A 10-mg/dL increase in FPG was associated with a -11-mL (95% CI -29 to 8 mL) difference in FVC and a -8-mL (95% CI -24 to 7 mL) difference in FEV1 in women, and a -32-mL (95% CI -44 to -21 mL) difference in FVC and a -19-mL (95% CI -28 to -9 mL) difference in FEV1 in men.

Conclusions: Inverse associations between glycemic measures and lung function were observed. Men seem more susceptible to the alteration in FVC and FEV1 than women.

Show MeSH
Related in: MedlinePlus