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Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population.

Liu M, He Y, Jiang B, Wu L, Yang S, Wang Y, Li X - Int J Endocrinol (2014)

Bottom Line: Objective.A two-stage stratified clustering sampling method was used and 2102 elderly participants were included.Results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.

ABSTRACT
Objective. This study aimed to evaluate the association between serum uric acid (SUA) levels within a normal to high range and the risk of metabolic syndrome (MetS) among community elderly and explore the sex difference. Design and Methods. A cross-sectional study was conducted in a representative urban area of Beijing between 2009 and 2010. A two-stage stratified clustering sampling method was used and 2102 elderly participants were included. Results. The prevalence of hyperuricemia and MetS was 16.7% and 59.1%, respectively. There was a strong association between hyperuricemia and four components of MetS in women and three components in men. Multiple logistic regression analysis showed ORs of hyperuricemia for MetS were 1.67 (95% CI: 1.11-2.50) in men and 2.73 (95% CI: 1.81-4.11) in women. Even in the normal range, the ORs for MetS increased gradually according to SUA levels. MetS component number also showed an increasing trend across SUA quartile in both sexes (P for trend < 0.01). Conclusion. This study suggests that higher SUA levels, even in the normal range, are positively associated with MetS among Chinese community elderly, and the association is stronger in women than men. Physicians should recognize MetS as a frequent comorbidity of hyperuricemia and take early action to prevent subsequent disease burden.

No MeSH data available.


Related in: MedlinePlus

Age and sex-specific prevalence of hyperuricemia.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Age and sex-specific prevalence of hyperuricemia.

Mentions: Figure 1 describes the prevalence of hyperuricemia by age and by sex. The prevalence showed an increasing trend with different age group (P for trend <0.001). Men had a higher prevalence in the younger elderly, but in the participants aged more than 70s, women had a higher prevalence.


Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population.

Liu M, He Y, Jiang B, Wu L, Yang S, Wang Y, Li X - Int J Endocrinol (2014)

Age and sex-specific prevalence of hyperuricemia.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4129973&req=5

fig1: Age and sex-specific prevalence of hyperuricemia.
Mentions: Figure 1 describes the prevalence of hyperuricemia by age and by sex. The prevalence showed an increasing trend with different age group (P for trend <0.001). Men had a higher prevalence in the younger elderly, but in the participants aged more than 70s, women had a higher prevalence.

Bottom Line: Objective.A two-stage stratified clustering sampling method was used and 2102 elderly participants were included.Results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.

ABSTRACT
Objective. This study aimed to evaluate the association between serum uric acid (SUA) levels within a normal to high range and the risk of metabolic syndrome (MetS) among community elderly and explore the sex difference. Design and Methods. A cross-sectional study was conducted in a representative urban area of Beijing between 2009 and 2010. A two-stage stratified clustering sampling method was used and 2102 elderly participants were included. Results. The prevalence of hyperuricemia and MetS was 16.7% and 59.1%, respectively. There was a strong association between hyperuricemia and four components of MetS in women and three components in men. Multiple logistic regression analysis showed ORs of hyperuricemia for MetS were 1.67 (95% CI: 1.11-2.50) in men and 2.73 (95% CI: 1.81-4.11) in women. Even in the normal range, the ORs for MetS increased gradually according to SUA levels. MetS component number also showed an increasing trend across SUA quartile in both sexes (P for trend < 0.01). Conclusion. This study suggests that higher SUA levels, even in the normal range, are positively associated with MetS among Chinese community elderly, and the association is stronger in women than men. Physicians should recognize MetS as a frequent comorbidity of hyperuricemia and take early action to prevent subsequent disease burden.

No MeSH data available.


Related in: MedlinePlus