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Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system.

Park YS, Cho JY, Lee SJ, Hwang CI - Biomed Res Int (2014)

Bottom Line: After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period.The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability.Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Anatomy, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-749, Republic of Korea ; Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA.

ABSTRACT
The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits. The drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone. The implant is hollow and has multiple microholes that can continuously deliver therapeutic agents into the systematic body. To examine the efficacy and feasibility of the IMDDS, we investigated the pharmacokinetic behavior of dexamethasone in plasma after a single dose was delivered via the modified implant placed in the rabbit tibia. After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period. The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability. Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases.

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Related in: MedlinePlus

The dexamethasone cartridge (a), the cartridge inserted into the implant (b), and the implant placed in the rabbit tibia (c).
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fig2: The dexamethasone cartridge (a), the cartridge inserted into the implant (b), and the implant placed in the rabbit tibia (c).

Mentions: During the implant placement, general anesthesia was induced by the intramuscular injection of 10 mg/kg of Zoletil (Virbac) and 0.15 mL/kg of Rompun (Bayer Korea, Seoul, Korea). Prior to surgery, the skin in the mesial proximal tibia was shaved and then washed with an iodine solution. A preoperative antibiotic (0.15 g kanamycin intramuscularly) was also administered prophylactically. One milliliter of a 2% lidocaine solution with 1 : 100,000 epinephrine was injected into the region of the planned surgery. A periosteal incision was made to expose the tibia. After dissecting the muscles and periosteum, the flat surface on the lateral aspect of the proximal tibia was selected for implant placement. A low-speed rotary engine was used to drill the hole for the implant under profuse irrigation with sterile saline. Each rabbit received one implant in the tibia. The entire surgery procedure was performed under sterile conditions to prevent infection. After surgery, each rabbit received an intramuscular injection of antibiotics (Figure 2). A more detailed description of the procedure is available in the previous publication by Lee et al. (2009) [17].


Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system.

Park YS, Cho JY, Lee SJ, Hwang CI - Biomed Res Int (2014)

The dexamethasone cartridge (a), the cartridge inserted into the implant (b), and the implant placed in the rabbit tibia (c).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129930&req=5

fig2: The dexamethasone cartridge (a), the cartridge inserted into the implant (b), and the implant placed in the rabbit tibia (c).
Mentions: During the implant placement, general anesthesia was induced by the intramuscular injection of 10 mg/kg of Zoletil (Virbac) and 0.15 mL/kg of Rompun (Bayer Korea, Seoul, Korea). Prior to surgery, the skin in the mesial proximal tibia was shaved and then washed with an iodine solution. A preoperative antibiotic (0.15 g kanamycin intramuscularly) was also administered prophylactically. One milliliter of a 2% lidocaine solution with 1 : 100,000 epinephrine was injected into the region of the planned surgery. A periosteal incision was made to expose the tibia. After dissecting the muscles and periosteum, the flat surface on the lateral aspect of the proximal tibia was selected for implant placement. A low-speed rotary engine was used to drill the hole for the implant under profuse irrigation with sterile saline. Each rabbit received one implant in the tibia. The entire surgery procedure was performed under sterile conditions to prevent infection. After surgery, each rabbit received an intramuscular injection of antibiotics (Figure 2). A more detailed description of the procedure is available in the previous publication by Lee et al. (2009) [17].

Bottom Line: After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period.The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability.Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Anatomy, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-749, Republic of Korea ; Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA.

ABSTRACT
The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits. The drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone. The implant is hollow and has multiple microholes that can continuously deliver therapeutic agents into the systematic body. To examine the efficacy and feasibility of the IMDDS, we investigated the pharmacokinetic behavior of dexamethasone in plasma after a single dose was delivered via the modified implant placed in the rabbit tibia. After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period. The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability. Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases.

Show MeSH
Related in: MedlinePlus