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Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleifera Leaves.

Asiedu-Gyekye IJ, Frimpong-Manso S, Awortwe C, Antwi DA, Nyarko AK - J Toxicol (2014)

Bottom Line: Results showed significant levels of thirty-five (35) elements (14 macroelements and 21 microelements) in M. oleifera extract.Although there were observed elevations in liver enzymes ALT and ALP (P < 0.001) and lower creatinine levels in the extract treated groups, no adverse histopathological findings were found.Moringa oleifera dried leaf extract may, therefore, be reasonably safe for consumption.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, College of Health Sciences, University of Ghana School of Pharmacy, P.O. Box LG 43, Legon, Ghana.

ABSTRACT
Moringa oleifera is a multipurpose plant used in Ghana and most parts of Africa. Its high mineral, protein, and vitamins content has enabled its use as a nutraceutical and panacea for various diseases. This study aimed at measuring the micro- and macroelements content of dried Moringa oleifera leaves using energy dispersive X-ray fluorescence spectroscopic (EDXRF) and assessing its toxicological effect in rats. Acute toxicity (5000 mg/kg) and a subacute toxicity studies of the leaf (40 mg/kg to 1000 mg/kg) extract were conducted in rats. Blood samples were assessed for biochemical and haematological parameters. Results showed significant levels of thirty-five (35) elements (14 macroelements and 21 microelements) in M. oleifera extract. There were no observed overt adverse reactions in the acute and subacute studies. Although there were observed elevations in liver enzymes ALT and ALP (P < 0.001) and lower creatinine levels in the extract treated groups, no adverse histopathological findings were found. Moringa oleifera dried leaf extract may, therefore, be reasonably safe for consumption. However, the consumption of Moringa oleifera leaves should not exceed a maximum of 70 grams per day to prevent cumulative toxicity of these essential elements over long periods.

No MeSH data available.


Related in: MedlinePlus

Photomicrographs of the stomach from male Sprague-Dawley rats. No observable ulceration. The epithelial cells are intact. Keys: (a): control, (b): 5000 mg/kg bwt, (c): 1000 mg/kg bwt, (d): 200 mg/kg bwt, (e): 80 mg/kg bwt, and (f): 40 mg/kg bwt.
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Related In: Results  -  Collection


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fig6: Photomicrographs of the stomach from male Sprague-Dawley rats. No observable ulceration. The epithelial cells are intact. Keys: (a): control, (b): 5000 mg/kg bwt, (c): 1000 mg/kg bwt, (d): 200 mg/kg bwt, (e): 80 mg/kg bwt, and (f): 40 mg/kg bwt.

Mentions: Photomicrographs of tissues prepared from control and animals treated with MOE at different dose levels are presented in Figures 5–8. No observable cardiomyopathy was noted in the heart (Figure 5). Figure 6 showed no observable ulceration. The epithelial cells of the stomach are intact. Figure 7 also showed no observable histological lesions in the glomerulus and the tubules. There were no observable histological lesions in the sinusoids and central vein of the liver (Figure 8).


Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleifera Leaves.

Asiedu-Gyekye IJ, Frimpong-Manso S, Awortwe C, Antwi DA, Nyarko AK - J Toxicol (2014)

Photomicrographs of the stomach from male Sprague-Dawley rats. No observable ulceration. The epithelial cells are intact. Keys: (a): control, (b): 5000 mg/kg bwt, (c): 1000 mg/kg bwt, (d): 200 mg/kg bwt, (e): 80 mg/kg bwt, and (f): 40 mg/kg bwt.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4129914&req=5

fig6: Photomicrographs of the stomach from male Sprague-Dawley rats. No observable ulceration. The epithelial cells are intact. Keys: (a): control, (b): 5000 mg/kg bwt, (c): 1000 mg/kg bwt, (d): 200 mg/kg bwt, (e): 80 mg/kg bwt, and (f): 40 mg/kg bwt.
Mentions: Photomicrographs of tissues prepared from control and animals treated with MOE at different dose levels are presented in Figures 5–8. No observable cardiomyopathy was noted in the heart (Figure 5). Figure 6 showed no observable ulceration. The epithelial cells of the stomach are intact. Figure 7 also showed no observable histological lesions in the glomerulus and the tubules. There were no observable histological lesions in the sinusoids and central vein of the liver (Figure 8).

Bottom Line: Results showed significant levels of thirty-five (35) elements (14 macroelements and 21 microelements) in M. oleifera extract.Although there were observed elevations in liver enzymes ALT and ALP (P < 0.001) and lower creatinine levels in the extract treated groups, no adverse histopathological findings were found.Moringa oleifera dried leaf extract may, therefore, be reasonably safe for consumption.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, College of Health Sciences, University of Ghana School of Pharmacy, P.O. Box LG 43, Legon, Ghana.

ABSTRACT
Moringa oleifera is a multipurpose plant used in Ghana and most parts of Africa. Its high mineral, protein, and vitamins content has enabled its use as a nutraceutical and panacea for various diseases. This study aimed at measuring the micro- and macroelements content of dried Moringa oleifera leaves using energy dispersive X-ray fluorescence spectroscopic (EDXRF) and assessing its toxicological effect in rats. Acute toxicity (5000 mg/kg) and a subacute toxicity studies of the leaf (40 mg/kg to 1000 mg/kg) extract were conducted in rats. Blood samples were assessed for biochemical and haematological parameters. Results showed significant levels of thirty-five (35) elements (14 macroelements and 21 microelements) in M. oleifera extract. There were no observed overt adverse reactions in the acute and subacute studies. Although there were observed elevations in liver enzymes ALT and ALP (P < 0.001) and lower creatinine levels in the extract treated groups, no adverse histopathological findings were found. Moringa oleifera dried leaf extract may, therefore, be reasonably safe for consumption. However, the consumption of Moringa oleifera leaves should not exceed a maximum of 70 grams per day to prevent cumulative toxicity of these essential elements over long periods.

No MeSH data available.


Related in: MedlinePlus