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Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times.

Liu M, Wang HR, Liu JF, Li HJ, Chen SX, Shen S, Pan SM - World J Emerg Med (2013)

Bottom Line: National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI.There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

ABSTRACT

Background: The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours.

Methods: A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.

Results: National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI. There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).

Conclusions: The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease. Therefore, intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe.

No MeSH data available.


Related in: MedlinePlus

Comparison of NIHSS scores between the two groups before and after thrombolysis. Compared within the same group, *P< 0.05.
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Figure 1: Comparison of NIHSS scores between the two groups before and after thrombolysis. Compared within the same group, *P< 0.05.

Mentions: The onset NIHSS scores in group B (6.50±1.61) was significantly lower than that in group A (9.46±4.95) (P<0.01). After thrombolysis treatment, NIHSS scores decreased in groups A and B. NIHSS scores in group A decreased to 3.55±5.20 at 7 days after thrombolysis treatment (P<0.01) (Figure 1). For the patients in group B, NIHSS scores decreased to 2.43± 2.82 at 24 hours after thrombolysis treatment (P<0.01), and to 1.57±2.28 at 7 days (P<0.01) (Figure 1). The results indicated that rt-PA thrombolysis treatment was useful for the patients.


Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times.

Liu M, Wang HR, Liu JF, Li HJ, Chen SX, Shen S, Pan SM - World J Emerg Med (2013)

Comparison of NIHSS scores between the two groups before and after thrombolysis. Compared within the same group, *P< 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129846&req=5

Figure 1: Comparison of NIHSS scores between the two groups before and after thrombolysis. Compared within the same group, *P< 0.05.
Mentions: The onset NIHSS scores in group B (6.50±1.61) was significantly lower than that in group A (9.46±4.95) (P<0.01). After thrombolysis treatment, NIHSS scores decreased in groups A and B. NIHSS scores in group A decreased to 3.55±5.20 at 7 days after thrombolysis treatment (P<0.01) (Figure 1). For the patients in group B, NIHSS scores decreased to 2.43± 2.82 at 24 hours after thrombolysis treatment (P<0.01), and to 1.57±2.28 at 7 days (P<0.01) (Figure 1). The results indicated that rt-PA thrombolysis treatment was useful for the patients.

Bottom Line: National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI.There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

ABSTRACT

Background: The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours.

Methods: A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.

Results: National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI. There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).

Conclusions: The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease. Therefore, intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe.

No MeSH data available.


Related in: MedlinePlus