Limits...
Therapeutic effects of smecta or smectite powder on rats with paraquat toxication.

Jiang YS, Ma YY, Wang ZQ, Li GJ - World J Emerg Med (2013)

Bottom Line: Abruption of mucosa, hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach.The hemorrhage of jejunum mucosa, the abruption of villus, the gland damage with the addition of inflammatory cell infiltration were found.Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Medicine, Affiliated Hospital of Shihezi University, Shihezi 832002, China.

ABSTRACT

Background: The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication, and the most common cause of death from paraquat poisoning is multiple organ failure (MOF). This study aimed to evaluate therapeutic effect of smecta on the plasma concentrations of paraquat and multi-organ injury induced by paraquat intoxication in rats.

Methods: A total of 76 healthy adult SD rats were randomly divided into group A (control group, n=6), group B (poisoned group, n=30) and group C (smecta-treated group, n=30). Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg, and rats in group A was treated intragastrically with saline (1 mL). Rats in group C were given intragastrically smecta at 400 mg/kg 10 minutes after administration of PQ, while rats in other two groups were treated intragastrically with 1 mL saline at the same time. Live rats in groups B and C were sacrificed at 2, 6, 24, 48, 72 hours after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of the lung, stomach and jejunum. The rats were executed at the end of trial by the same way in group A.

Results: The plasma concentration of paraquat (ng/mL) ranged from 440.314±49.776 to 4320.6150±413.947. Distinctive pathological changes were seen in the lung, stomach and jejunum in group B. Lung injuries deteriorated gradually, edema, leukocyte infiltration, pneumorrhagia, incrassated septa and lung consolidation were observed. Abruption of mucosa, hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach. The hemorrhage of jejunum mucosa, the abruption of villus, the gland damage with the addition of inflammatory cell infiltration were found. Compared to group B, the plasma concentration of paraquat reduced (P<0.01) and the pathological changes mentioned above were obviously alleviated in group C (P<0.05, P<0.01).

Conclusion: Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.

No MeSH data available.


Related in: MedlinePlus

Comparison of PQ concentrations between groups B and C. P value at 2, 6, 24, 48, 72 hours after PQ administration was 0.000, 0.001, 0.017, 0.001, and 0.000, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4129834&req=5

Figure 4: Comparison of PQ concentrations between groups B and C. P value at 2, 6, 24, 48, 72 hours after PQ administration was 0.000, 0.001, 0.017, 0.001, and 0.000, respectively.

Mentions: In groups B and C, the plasma concentration of PQ lowered with the time, peaked at 2 hours after PQ administration, and kept at a higher level within 6 hours after intoxication. After that, the plasma concentration of PQ started to decrease, and reached the minimum level 72 hours after PQ administration (Figure 4). Compared to group B, the plasma concentration of PQ in group C reduced rapidly, but there was no significant difference between the two groups (P<0.05 or P<0.01).


Therapeutic effects of smecta or smectite powder on rats with paraquat toxication.

Jiang YS, Ma YY, Wang ZQ, Li GJ - World J Emerg Med (2013)

Comparison of PQ concentrations between groups B and C. P value at 2, 6, 24, 48, 72 hours after PQ administration was 0.000, 0.001, 0.017, 0.001, and 0.000, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129834&req=5

Figure 4: Comparison of PQ concentrations between groups B and C. P value at 2, 6, 24, 48, 72 hours after PQ administration was 0.000, 0.001, 0.017, 0.001, and 0.000, respectively.
Mentions: In groups B and C, the plasma concentration of PQ lowered with the time, peaked at 2 hours after PQ administration, and kept at a higher level within 6 hours after intoxication. After that, the plasma concentration of PQ started to decrease, and reached the minimum level 72 hours after PQ administration (Figure 4). Compared to group B, the plasma concentration of PQ in group C reduced rapidly, but there was no significant difference between the two groups (P<0.05 or P<0.01).

Bottom Line: Abruption of mucosa, hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach.The hemorrhage of jejunum mucosa, the abruption of villus, the gland damage with the addition of inflammatory cell infiltration were found.Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Medicine, Affiliated Hospital of Shihezi University, Shihezi 832002, China.

ABSTRACT

Background: The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication, and the most common cause of death from paraquat poisoning is multiple organ failure (MOF). This study aimed to evaluate therapeutic effect of smecta on the plasma concentrations of paraquat and multi-organ injury induced by paraquat intoxication in rats.

Methods: A total of 76 healthy adult SD rats were randomly divided into group A (control group, n=6), group B (poisoned group, n=30) and group C (smecta-treated group, n=30). Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg, and rats in group A was treated intragastrically with saline (1 mL). Rats in group C were given intragastrically smecta at 400 mg/kg 10 minutes after administration of PQ, while rats in other two groups were treated intragastrically with 1 mL saline at the same time. Live rats in groups B and C were sacrificed at 2, 6, 24, 48, 72 hours after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of the lung, stomach and jejunum. The rats were executed at the end of trial by the same way in group A.

Results: The plasma concentration of paraquat (ng/mL) ranged from 440.314±49.776 to 4320.6150±413.947. Distinctive pathological changes were seen in the lung, stomach and jejunum in group B. Lung injuries deteriorated gradually, edema, leukocyte infiltration, pneumorrhagia, incrassated septa and lung consolidation were observed. Abruption of mucosa, hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach. The hemorrhage of jejunum mucosa, the abruption of villus, the gland damage with the addition of inflammatory cell infiltration were found. Compared to group B, the plasma concentration of paraquat reduced (P<0.01) and the pathological changes mentioned above were obviously alleviated in group C (P<0.05, P<0.01).

Conclusion: Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.

No MeSH data available.


Related in: MedlinePlus