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Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

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Interaction plot; effect of the amount of glycerol on tensile strength at various thicknesses of films with nonwoven textile.
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fig6: Interaction plot; effect of the amount of glycerol on tensile strength at various thicknesses of films with nonwoven textile.

Mentions: Characteristics of models for films with a nonwoven textile are summarized in Table 4. In general, all measured texture parameters were significantly smaller compared to films without the nonwoven textile. Unlike films without a nonwoven textile, interaction between the amount of glycerol and film thickness was observed. The results show that the best texture parameter for describing dependence between the amount of glycerol and film thickness was tensile strength with excellent regression characteristics, followed by puncture strength. These parameters were again strongly correlated but increasing the amount of glycerol from 1% to 3% did not lead to a decrease similar to that in the films without a nonwoven textile (Table 2). Figure 6 shows that film thickness significantly affects tensile strength for 1% concentration of glycerol. Film thickness had practically no effect on films with 3% of glycerol. Greater recalculated tensile strength and puncture strength, respectively, were needed for thicker films (solid line), unlike films without nonwoven textile. The concentration of glycerol was a parameter which had a strong negative effect on tensile strength; that is, a high concentration of glycerol led to low tensile strength, regardless of the film thickness. Another suitable parameter to describe the dependence between the amount of glycerol and film thickness was tensile work. Again, film thickness affected tensile work and puncture work in films with a lower amount of glycerol and had almost no effect on films with higher amounts of glycerol (Figure 7).


Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

Interaction plot; effect of the amount of glycerol on tensile strength at various thicknesses of films with nonwoven textile.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129671&req=5

fig6: Interaction plot; effect of the amount of glycerol on tensile strength at various thicknesses of films with nonwoven textile.
Mentions: Characteristics of models for films with a nonwoven textile are summarized in Table 4. In general, all measured texture parameters were significantly smaller compared to films without the nonwoven textile. Unlike films without a nonwoven textile, interaction between the amount of glycerol and film thickness was observed. The results show that the best texture parameter for describing dependence between the amount of glycerol and film thickness was tensile strength with excellent regression characteristics, followed by puncture strength. These parameters were again strongly correlated but increasing the amount of glycerol from 1% to 3% did not lead to a decrease similar to that in the films without a nonwoven textile (Table 2). Figure 6 shows that film thickness significantly affects tensile strength for 1% concentration of glycerol. Film thickness had practically no effect on films with 3% of glycerol. Greater recalculated tensile strength and puncture strength, respectively, were needed for thicker films (solid line), unlike films without nonwoven textile. The concentration of glycerol was a parameter which had a strong negative effect on tensile strength; that is, a high concentration of glycerol led to low tensile strength, regardless of the film thickness. Another suitable parameter to describe the dependence between the amount of glycerol and film thickness was tensile work. Again, film thickness affected tensile work and puncture work in films with a lower amount of glycerol and had almost no effect on films with higher amounts of glycerol (Figure 7).

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

Show MeSH
Related in: MedlinePlus