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Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

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Interaction plot; (a) effect of the amount of glycerol on puncture work at various thicknesses of films without nonwoven textile; (b) effect of the amount of glycerol on tensile work at various thicknesses of films without nonwoven textile.
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fig5: Interaction plot; (a) effect of the amount of glycerol on puncture work at various thicknesses of films without nonwoven textile; (b) effect of the amount of glycerol on tensile work at various thicknesses of films without nonwoven textile.

Mentions: The characteristics of models for films without a nonwoven textile are summarized in Table 3. Until now, a general observation is known that the deformation/elongation of film increases with plasticizer content [14, 21]. In this experiment, it was found that puncture strength and tensile strength had similar regression characteristics. The effect of the interaction between the amount of glycerol and the film thickness did not occur as shown in Figure 4 where the lines are parallel; that is, increase in the amount of glycerol from 1% to 3% led to approximately the same decrease in the recalculated tensile strength for both film thicknesses. Greater recalculated tensile strength and puncture strength were needed for thinner films (dashed line). A greater recalculated tensile strength was also found for thinner films containing NaCMC and propylene glycol as plasticizer in Verma and Chattopadhyay's experiment [22]. Puncture work and tensile work were not correlated; therefore texture characteristics are manifested differently in graphs of interactions (Figures 5(a) and 5(b)).


Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

Interaction plot; (a) effect of the amount of glycerol on puncture work at various thicknesses of films without nonwoven textile; (b) effect of the amount of glycerol on tensile work at various thicknesses of films without nonwoven textile.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129671&req=5

fig5: Interaction plot; (a) effect of the amount of glycerol on puncture work at various thicknesses of films without nonwoven textile; (b) effect of the amount of glycerol on tensile work at various thicknesses of films without nonwoven textile.
Mentions: The characteristics of models for films without a nonwoven textile are summarized in Table 3. Until now, a general observation is known that the deformation/elongation of film increases with plasticizer content [14, 21]. In this experiment, it was found that puncture strength and tensile strength had similar regression characteristics. The effect of the interaction between the amount of glycerol and the film thickness did not occur as shown in Figure 4 where the lines are parallel; that is, increase in the amount of glycerol from 1% to 3% led to approximately the same decrease in the recalculated tensile strength for both film thicknesses. Greater recalculated tensile strength and puncture strength were needed for thinner films (dashed line). A greater recalculated tensile strength was also found for thinner films containing NaCMC and propylene glycol as plasticizer in Verma and Chattopadhyay's experiment [22]. Puncture work and tensile work were not correlated; therefore texture characteristics are manifested differently in graphs of interactions (Figures 5(a) and 5(b)).

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

Show MeSH
Related in: MedlinePlus