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Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

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PCA; (a) scores plot; (b) correlation loadings plot, data of films with a nonwoven textile, positive correlation marked with a circle. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).
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fig3: PCA; (a) scores plot; (b) correlation loadings plot, data of films with a nonwoven textile, positive correlation marked with a circle. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).

Mentions: A separate PCA model for the data of films with a nonwoven textile was further calculated. The correlation loadings plot (Figure 3(b)) describes the relationship between variables in the data. In particular, variability of strongly correlated variables of tensile strength and tensile work, puncture strength and, in the specific case of these nonwoven textile films, puncture work are explained to some extent by the distribution of films into two groups according to their thicknesses (Figure 3(a)). Thicker films (27 mL) have a greater variability depending on the amount of glycerol as compared to thinner films (18 mL) which reflects different variance of each group along PC-1 and PC-2, respectively.


Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

PCA; (a) scores plot; (b) correlation loadings plot, data of films with a nonwoven textile, positive correlation marked with a circle. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129671&req=5

fig3: PCA; (a) scores plot; (b) correlation loadings plot, data of films with a nonwoven textile, positive correlation marked with a circle. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).
Mentions: A separate PCA model for the data of films with a nonwoven textile was further calculated. The correlation loadings plot (Figure 3(b)) describes the relationship between variables in the data. In particular, variability of strongly correlated variables of tensile strength and tensile work, puncture strength and, in the specific case of these nonwoven textile films, puncture work are explained to some extent by the distribution of films into two groups according to their thicknesses (Figure 3(a)). Thicker films (27 mL) have a greater variability depending on the amount of glycerol as compared to thinner films (18 mL) which reflects different variance of each group along PC-1 and PC-2, respectively.

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

Show MeSH
Related in: MedlinePlus