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Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

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PCA; (a) scores plot; (b) correlation loadings plot, data of films without a nonwoven textile, positive correlation marked with a circle, and negative correlation indicated by an arrow. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).
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fig2: PCA; (a) scores plot; (b) correlation loadings plot, data of films without a nonwoven textile, positive correlation marked with a circle, and negative correlation indicated by an arrow. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).

Mentions: A PCA model was constructed for data of films without a nonwoven textile. A systematic distribution of objects along the PC-1 depending on the content of glycerol in the films is shown in the scores plot (Figure 2(a)). The data distribution of the films with higher concentrations of glycerol (2.5%, 3%) is divided into two branches along the PC-2 component, which can be assigned to the variable pun. work. The correlation loadings plot (Figure 2(b)) together with the scores plot (Figure 2(a)) shows that puncture work was influenced by the thickness of the film differently compared to the rest of film characteristics, as the opposite effect in films containing 2.5–3% of glycerol was observed. The increased amount of glycerol in films C4 and C5 (18 mL) led to an increase in puncture work and conversely to a decrease in this work in films D4 and D5 (27 mL). The effect of the amount of glycerol used is well described by the parameters of the texture analysis located along PC-1 (Figure 2(b)). Moreover, some parameters are strongly correlated, both positively and negatively. Correlated parameters have the potential to explain a similar part of variability in the data. This may have the practical consequence of using only one of the parameters to obtain the necessary information about the film characteristics. Puncture strength, tensile strength, and tensile work positively correlated, and tensile deformation negatively correlated with these parameters.


Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.

Landová H, Vetchý D, Gajdziok J, Doležel P, Muselík J, Dvořáčková K, Jekl V, Hauptman K, Knotek Z - Biomed Res Int (2014)

PCA; (a) scores plot; (b) correlation loadings plot, data of films without a nonwoven textile, positive correlation marked with a circle, and negative correlation indicated by an arrow. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129671&req=5

fig2: PCA; (a) scores plot; (b) correlation loadings plot, data of films without a nonwoven textile, positive correlation marked with a circle, and negative correlation indicated by an arrow. Objects are labeled according to design parameters: %(glycerol)_ml(casted amount).
Mentions: A PCA model was constructed for data of films without a nonwoven textile. A systematic distribution of objects along the PC-1 depending on the content of glycerol in the films is shown in the scores plot (Figure 2(a)). The data distribution of the films with higher concentrations of glycerol (2.5%, 3%) is divided into two branches along the PC-2 component, which can be assigned to the variable pun. work. The correlation loadings plot (Figure 2(b)) together with the scores plot (Figure 2(a)) shows that puncture work was influenced by the thickness of the film differently compared to the rest of film characteristics, as the opposite effect in films containing 2.5–3% of glycerol was observed. The increased amount of glycerol in films C4 and C5 (18 mL) led to an increase in puncture work and conversely to a decrease in this work in films D4 and D5 (27 mL). The effect of the amount of glycerol used is well described by the parameters of the texture analysis located along PC-1 (Figure 2(b)). Moreover, some parameters are strongly correlated, both positively and negatively. Correlated parameters have the potential to explain a similar part of variability in the data. This may have the practical consequence of using only one of the parameters to obtain the necessary information about the film characteristics. Puncture strength, tensile strength, and tensile work positively correlated, and tensile deformation negatively correlated with these parameters.

Bottom Line: Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.

ABSTRACT
Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.

Show MeSH
Related in: MedlinePlus