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Neurophysiological correlates of configural face processing in schizotypy.

Batty RA, Francis AJ, Innes-Brown H, Joshua NR, Rossell SL - Front Psychiatry (2014)

Bottom Line: Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations.No group differences were shown for P100 analyses.This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

View Article: PubMed Central - PubMed

Affiliation: Brain and Psychological Sciences Research Centre (BPsyC), Faculty of Health, Arts and Design, Swinburne University of Technology , Melbourne, VIC , Australia ; School of Health Science, Psychology, RMIT University , Bundoora, VIC , Australia.

ABSTRACT

Background: Face processing impairment in schizophrenia appears to be underpinned by poor configural (as opposed to feature-based) processing; however, few studies have sought to characterize this impairment electrophysiologically. Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations. However, this is the first known neurophysiological investigation of configural face processing in a non-clinical schizotypal sample.

Methods: Using stimuli designed to engage configural processing in face perception (upright and inverted Mooney and photographic faces), P100 and N170 components were recorded in healthy individuals characterized by high (N = 14) and low (N = 14) schizotypal traits according to the Oxford-Liverpool Inventory of Feelings and Experiences.

Results: High schizotypes showed significantly reduced N170 amplitudes to inverted photographic faces. Typical N170 latency and amplitude inversion effects (delayed and enhanced N170 to inverted relative to upright photographic faces, and enhanced amplitude to upright versus inverted Mooney faces), were demonstrated by low, but not high, schizotypes. No group differences were shown for P100 analyses.

Conclusions: The findings suggest that neurophysiological deficits in processing facial configurations (N170) are apparent in schizotypy, while the early sensory processing (P100) of faces appears intact. This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

No MeSH data available.


Related in: MedlinePlus

N170 latency group × orientation interaction effect. Comparable peak latencies are shown to upright stimuli by both groups, however, high schizotypes show earlier peak latencies to inverted face stimuli (most difficult to perceive).
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Figure 3: N170 latency group × orientation interaction effect. Comparable peak latencies are shown to upright stimuli by both groups, however, high schizotypes show earlier peak latencies to inverted face stimuli (most difficult to perceive).

Mentions: Mean (SD) amplitude and latency to upright and inverted stimuli for both tasks are shown in Table 5, and N170 waveforms at P07/08 are shown in Figure 2. Earlier N170 latencies were shown to photographic (M = 154.72 ms, SD = 10.06), than to Mooney (M = 174.63 ms, SD = 10.33) faces: F(1,26) = 79.52, p < 0.001, and to upright (M = 163.02 ms, SD = 8.68) than inverted (M = 166.33 ms, SD = 8.61) faces: F(1,26) = 18.67, p < 0.001, . A task × orientation interaction demonstrated similar latencies to upright and inverted Mooney faces, whereas upright photographic faces were marked by earlier latencies relative to inverted photographic faces: F(1,26) = 8.83, p = 0.006, (see Table 5). The left hemisphere showed earlier latencies (M = 162.54 ms, SD = 9.54), than the right (M = 163.50 ms, SD = 9.09) to upright faces, whereas this effect was reversed for inverted faces where earlier latencies were shown in the right hemisphere (M = 165.20 ms, SD = 9.38) versus left (M = 167.46 ms, SD = 9.36): orientation × hemisphere interaction, F(1,26) = 4.69, p = 0.04, . While there was no main effect for schizotypy group (p = 0.63), a group × orientation interaction was shown. The low schizotypy group had earlier latencies for upright relative to inverted faces; however, the high schizotypy group had comparable latencies across orientations: F(1,26) = 8.41, p = 0.007, (see Table 5; Figure 3). A task × orientation × group interaction was at trend level (p = 0.067).


Neurophysiological correlates of configural face processing in schizotypy.

Batty RA, Francis AJ, Innes-Brown H, Joshua NR, Rossell SL - Front Psychiatry (2014)

N170 latency group × orientation interaction effect. Comparable peak latencies are shown to upright stimuli by both groups, however, high schizotypes show earlier peak latencies to inverted face stimuli (most difficult to perceive).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129627&req=5

Figure 3: N170 latency group × orientation interaction effect. Comparable peak latencies are shown to upright stimuli by both groups, however, high schizotypes show earlier peak latencies to inverted face stimuli (most difficult to perceive).
Mentions: Mean (SD) amplitude and latency to upright and inverted stimuli for both tasks are shown in Table 5, and N170 waveforms at P07/08 are shown in Figure 2. Earlier N170 latencies were shown to photographic (M = 154.72 ms, SD = 10.06), than to Mooney (M = 174.63 ms, SD = 10.33) faces: F(1,26) = 79.52, p < 0.001, and to upright (M = 163.02 ms, SD = 8.68) than inverted (M = 166.33 ms, SD = 8.61) faces: F(1,26) = 18.67, p < 0.001, . A task × orientation interaction demonstrated similar latencies to upright and inverted Mooney faces, whereas upright photographic faces were marked by earlier latencies relative to inverted photographic faces: F(1,26) = 8.83, p = 0.006, (see Table 5). The left hemisphere showed earlier latencies (M = 162.54 ms, SD = 9.54), than the right (M = 163.50 ms, SD = 9.09) to upright faces, whereas this effect was reversed for inverted faces where earlier latencies were shown in the right hemisphere (M = 165.20 ms, SD = 9.38) versus left (M = 167.46 ms, SD = 9.36): orientation × hemisphere interaction, F(1,26) = 4.69, p = 0.04, . While there was no main effect for schizotypy group (p = 0.63), a group × orientation interaction was shown. The low schizotypy group had earlier latencies for upright relative to inverted faces; however, the high schizotypy group had comparable latencies across orientations: F(1,26) = 8.41, p = 0.007, (see Table 5; Figure 3). A task × orientation × group interaction was at trend level (p = 0.067).

Bottom Line: Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations.No group differences were shown for P100 analyses.This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

View Article: PubMed Central - PubMed

Affiliation: Brain and Psychological Sciences Research Centre (BPsyC), Faculty of Health, Arts and Design, Swinburne University of Technology , Melbourne, VIC , Australia ; School of Health Science, Psychology, RMIT University , Bundoora, VIC , Australia.

ABSTRACT

Background: Face processing impairment in schizophrenia appears to be underpinned by poor configural (as opposed to feature-based) processing; however, few studies have sought to characterize this impairment electrophysiologically. Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations. However, this is the first known neurophysiological investigation of configural face processing in a non-clinical schizotypal sample.

Methods: Using stimuli designed to engage configural processing in face perception (upright and inverted Mooney and photographic faces), P100 and N170 components were recorded in healthy individuals characterized by high (N = 14) and low (N = 14) schizotypal traits according to the Oxford-Liverpool Inventory of Feelings and Experiences.

Results: High schizotypes showed significantly reduced N170 amplitudes to inverted photographic faces. Typical N170 latency and amplitude inversion effects (delayed and enhanced N170 to inverted relative to upright photographic faces, and enhanced amplitude to upright versus inverted Mooney faces), were demonstrated by low, but not high, schizotypes. No group differences were shown for P100 analyses.

Conclusions: The findings suggest that neurophysiological deficits in processing facial configurations (N170) are apparent in schizotypy, while the early sensory processing (P100) of faces appears intact. This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

No MeSH data available.


Related in: MedlinePlus