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Neurophysiological correlates of configural face processing in schizotypy.

Batty RA, Francis AJ, Innes-Brown H, Joshua NR, Rossell SL - Front Psychiatry (2014)

Bottom Line: Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations.No group differences were shown for P100 analyses.This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

View Article: PubMed Central - PubMed

Affiliation: Brain and Psychological Sciences Research Centre (BPsyC), Faculty of Health, Arts and Design, Swinburne University of Technology , Melbourne, VIC , Australia ; School of Health Science, Psychology, RMIT University , Bundoora, VIC , Australia.

ABSTRACT

Background: Face processing impairment in schizophrenia appears to be underpinned by poor configural (as opposed to feature-based) processing; however, few studies have sought to characterize this impairment electrophysiologically. Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations. However, this is the first known neurophysiological investigation of configural face processing in a non-clinical schizotypal sample.

Methods: Using stimuli designed to engage configural processing in face perception (upright and inverted Mooney and photographic faces), P100 and N170 components were recorded in healthy individuals characterized by high (N = 14) and low (N = 14) schizotypal traits according to the Oxford-Liverpool Inventory of Feelings and Experiences.

Results: High schizotypes showed significantly reduced N170 amplitudes to inverted photographic faces. Typical N170 latency and amplitude inversion effects (delayed and enhanced N170 to inverted relative to upright photographic faces, and enhanced amplitude to upright versus inverted Mooney faces), were demonstrated by low, but not high, schizotypes. No group differences were shown for P100 analyses.

Conclusions: The findings suggest that neurophysiological deficits in processing facial configurations (N170) are apparent in schizotypy, while the early sensory processing (P100) of faces appears intact. This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

No MeSH data available.


Related in: MedlinePlus

Grand-averaged P100 waveforms at electrode OZ. Upright and inverted stimuli presentations across groups are compared for both tasks. A bird’s eye view of the electrode montage is shown with the plotted electrode shaded black. Negative polarity is plotted downward.
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Figure 1: Grand-averaged P100 waveforms at electrode OZ. Upright and inverted stimuli presentations across groups are compared for both tasks. A bird’s eye view of the electrode montage is shown with the plotted electrode shaded black. Negative polarity is plotted downward.

Mentions: Mean (SD) amplitudes and latencies are presented in Table 4, and grand-averaged waveforms are illustrated in Figure 1. P100 latency was increased for inverted relative to upright faces at electrode O1; F(1,25) = 6.22, p = 0.02, . Larger amplitudes were shown to photographic than Mooney faces at all three occipital sites: (i) O1; F(1,25) = 10.20, p = 0.004, (ii) OZ; F(1,25) = 10.81, p = 0.003, (iii) O2; F(1,25) = 8.68, p = 0.007, . Greater amplitude to inverted versus upright faces was shown at electrode O2 only; F(1,25) = 14.74, p = 0.001, (trend level at OZ, p = 0.06). No differences between schizotypal groups were shown for P100 latency: (i) O1; p = 0.85, (ii) OZ; p = 0.54, (iii) O2; p = 0.61, or P100 amplitude: (i) O1; p = 0.19, (ii) OZ; p = 0.63, (iii) O2; p = 0.35. No other significant P100 effects were shown.


Neurophysiological correlates of configural face processing in schizotypy.

Batty RA, Francis AJ, Innes-Brown H, Joshua NR, Rossell SL - Front Psychiatry (2014)

Grand-averaged P100 waveforms at electrode OZ. Upright and inverted stimuli presentations across groups are compared for both tasks. A bird’s eye view of the electrode montage is shown with the plotted electrode shaded black. Negative polarity is plotted downward.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129627&req=5

Figure 1: Grand-averaged P100 waveforms at electrode OZ. Upright and inverted stimuli presentations across groups are compared for both tasks. A bird’s eye view of the electrode montage is shown with the plotted electrode shaded black. Negative polarity is plotted downward.
Mentions: Mean (SD) amplitudes and latencies are presented in Table 4, and grand-averaged waveforms are illustrated in Figure 1. P100 latency was increased for inverted relative to upright faces at electrode O1; F(1,25) = 6.22, p = 0.02, . Larger amplitudes were shown to photographic than Mooney faces at all three occipital sites: (i) O1; F(1,25) = 10.20, p = 0.004, (ii) OZ; F(1,25) = 10.81, p = 0.003, (iii) O2; F(1,25) = 8.68, p = 0.007, . Greater amplitude to inverted versus upright faces was shown at electrode O2 only; F(1,25) = 14.74, p = 0.001, (trend level at OZ, p = 0.06). No differences between schizotypal groups were shown for P100 latency: (i) O1; p = 0.85, (ii) OZ; p = 0.54, (iii) O2; p = 0.61, or P100 amplitude: (i) O1; p = 0.19, (ii) OZ; p = 0.63, (iii) O2; p = 0.35. No other significant P100 effects were shown.

Bottom Line: Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations.No group differences were shown for P100 analyses.This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

View Article: PubMed Central - PubMed

Affiliation: Brain and Psychological Sciences Research Centre (BPsyC), Faculty of Health, Arts and Design, Swinburne University of Technology , Melbourne, VIC , Australia ; School of Health Science, Psychology, RMIT University , Bundoora, VIC , Australia.

ABSTRACT

Background: Face processing impairment in schizophrenia appears to be underpinned by poor configural (as opposed to feature-based) processing; however, few studies have sought to characterize this impairment electrophysiologically. Given the sensitivity of event-related potentials to antipsychotic medications, and the potential for neurophysiological abnormalities to serve as vulnerability markers for schizophrenia, a handful of studies have investigated early visual P100 and face-selective N170 in "at risk" populations. However, this is the first known neurophysiological investigation of configural face processing in a non-clinical schizotypal sample.

Methods: Using stimuli designed to engage configural processing in face perception (upright and inverted Mooney and photographic faces), P100 and N170 components were recorded in healthy individuals characterized by high (N = 14) and low (N = 14) schizotypal traits according to the Oxford-Liverpool Inventory of Feelings and Experiences.

Results: High schizotypes showed significantly reduced N170 amplitudes to inverted photographic faces. Typical N170 latency and amplitude inversion effects (delayed and enhanced N170 to inverted relative to upright photographic faces, and enhanced amplitude to upright versus inverted Mooney faces), were demonstrated by low, but not high, schizotypes. No group differences were shown for P100 analyses.

Conclusions: The findings suggest that neurophysiological deficits in processing facial configurations (N170) are apparent in schizotypy, while the early sensory processing (P100) of faces appears intact. This work adds to the mounting evidence for analogous neural processing anomalies at the healthy end of the psychosis continuum.

No MeSH data available.


Related in: MedlinePlus