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Vitamin D status in adult critically ill patients in Eastern India: An observational retrospective study.

Padhi R, Panda B, Jagati S, Patra SC - Lung India (2014)

Bottom Line: Continuous variables were compared by using unpaired t-tests, Welch's tests, or Wilcoxon ranksum tests.The time from inclusion to death in the two groups was compared with the use of the log-rank test, and the results are presented as Kaplan-Meier curves.All P values were 2-tailed and P < 0.05 was considered statistically significant.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Division of Critical Care, Institute of Medical Sciences and Sum Hospital, Bhubaneswar, Odisha, India.

ABSTRACT

Background: The prevalence of vitamin D deficiency in critically ill patients has been reported to be as high as 80%. There is insufficient data regarding the relationship between 25-hydroxyvitamin D [25(OH) D] levels and outcomes in medical intensive care unit (MICU). The goal of this study was to evaluate the prevalence of 25(OH) D deficiency in MICU and its relationship with outcomes.

Subjects and methods: This was a retrospective study in a MICU of a teaching medical college hospital of Eastern India. All patients admitted to MICU, who had levels of 25(OH) D available, were included in the study. The discriminative powers of admission and lowest 25(OH) D values regarding day-30 mortality were evaluated by producing receiver operating curves (ROC). Binary end points were analyzed by means of a Fisher's exact test. Continuous variables were compared by using unpaired t-tests, Welch's tests, or Wilcoxon ranksum tests. All odds ratios and their corresponding 95% confidence intervals were calculated according to the profile-likelihood method. The time from inclusion to death in the two groups was compared with the use of the log-rank test, and the results are presented as Kaplan-Meier curves. Hazard ratios for death from hypo 25(OH) D were calculated by logistic regression model. All P values were 2-tailed and P < 0.05 was considered statistically significant.

Results: Of the 300 patients admitted during the study period, 25(OH) D levels were available in 152 patients (50.6%). Of these 152 patients, 15 patients (9.8%) had 25(OH) D insufficiency (20-29.9 ng/dL), 79 (51.9%) had 25(OH) D deficiency (0-19.9 ng/dL), and the levels were normal (>30 ng/dl) in 58 (38.2%) patients. Most of the patients with deficient 25(OH) D levels were females (P < 0.05). Higher mortality (P = 0.01), increased length of MICU stay, and prolonged ventilation were observed in patients with 25(OH) D deficiency.

Conclusions: Patients with 25(OH) D deficiency in MICU have increased hospital mortality, longer mechanical ventilation, and longer MICU stay.

No MeSH data available.


Related in: MedlinePlus

30 days mortality in the two groups
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Figure 1: 30 days mortality in the two groups

Mentions: Of the 300 patients admitted during the study period, 25(OH) D levels were available in 152 patients (50.67%). Fifteen patients had 25(OH) D insufficiency (20-29.9 ng/dL), 79 (51.9%) had 25(OH) D deficiency (0-19.9 ng/dl) whereas the levels were normal (>30ng/dl) in 58 (38.2%) patients. Baseline characteristics of study patients are given in Table 1. 25(OH) D deficiency was significantly more frequent among the females (P < 0.05). Outcomes and adverse events are given in Table 2. Hospital mortality was higher in patients with 25(OH) D deficiency and insufficiency (P = 0.01), odds ratio 0.39, 95% confidence interval 0.94-0.67 [Table 2 and Figure 1]. MICU patients with 25(OH) D deficiency and insufficiency had prolonged mechanical ventilation [Table 2 and Figure 2; P < 0.05) including a prolonged length of MICU stay [Table 2, P = 0.01]. There was no statistically significant difference in the need for renal replacement therapy in the three groups (P > 0.05).


Vitamin D status in adult critically ill patients in Eastern India: An observational retrospective study.

Padhi R, Panda B, Jagati S, Patra SC - Lung India (2014)

30 days mortality in the two groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129590&req=5

Figure 1: 30 days mortality in the two groups
Mentions: Of the 300 patients admitted during the study period, 25(OH) D levels were available in 152 patients (50.67%). Fifteen patients had 25(OH) D insufficiency (20-29.9 ng/dL), 79 (51.9%) had 25(OH) D deficiency (0-19.9 ng/dl) whereas the levels were normal (>30ng/dl) in 58 (38.2%) patients. Baseline characteristics of study patients are given in Table 1. 25(OH) D deficiency was significantly more frequent among the females (P < 0.05). Outcomes and adverse events are given in Table 2. Hospital mortality was higher in patients with 25(OH) D deficiency and insufficiency (P = 0.01), odds ratio 0.39, 95% confidence interval 0.94-0.67 [Table 2 and Figure 1]. MICU patients with 25(OH) D deficiency and insufficiency had prolonged mechanical ventilation [Table 2 and Figure 2; P < 0.05) including a prolonged length of MICU stay [Table 2, P = 0.01]. There was no statistically significant difference in the need for renal replacement therapy in the three groups (P > 0.05).

Bottom Line: Continuous variables were compared by using unpaired t-tests, Welch's tests, or Wilcoxon ranksum tests.The time from inclusion to death in the two groups was compared with the use of the log-rank test, and the results are presented as Kaplan-Meier curves.All P values were 2-tailed and P < 0.05 was considered statistically significant.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Division of Critical Care, Institute of Medical Sciences and Sum Hospital, Bhubaneswar, Odisha, India.

ABSTRACT

Background: The prevalence of vitamin D deficiency in critically ill patients has been reported to be as high as 80%. There is insufficient data regarding the relationship between 25-hydroxyvitamin D [25(OH) D] levels and outcomes in medical intensive care unit (MICU). The goal of this study was to evaluate the prevalence of 25(OH) D deficiency in MICU and its relationship with outcomes.

Subjects and methods: This was a retrospective study in a MICU of a teaching medical college hospital of Eastern India. All patients admitted to MICU, who had levels of 25(OH) D available, were included in the study. The discriminative powers of admission and lowest 25(OH) D values regarding day-30 mortality were evaluated by producing receiver operating curves (ROC). Binary end points were analyzed by means of a Fisher's exact test. Continuous variables were compared by using unpaired t-tests, Welch's tests, or Wilcoxon ranksum tests. All odds ratios and their corresponding 95% confidence intervals were calculated according to the profile-likelihood method. The time from inclusion to death in the two groups was compared with the use of the log-rank test, and the results are presented as Kaplan-Meier curves. Hazard ratios for death from hypo 25(OH) D were calculated by logistic regression model. All P values were 2-tailed and P < 0.05 was considered statistically significant.

Results: Of the 300 patients admitted during the study period, 25(OH) D levels were available in 152 patients (50.6%). Of these 152 patients, 15 patients (9.8%) had 25(OH) D insufficiency (20-29.9 ng/dL), 79 (51.9%) had 25(OH) D deficiency (0-19.9 ng/dL), and the levels were normal (>30 ng/dl) in 58 (38.2%) patients. Most of the patients with deficient 25(OH) D levels were females (P < 0.05). Higher mortality (P = 0.01), increased length of MICU stay, and prolonged ventilation were observed in patients with 25(OH) D deficiency.

Conclusions: Patients with 25(OH) D deficiency in MICU have increased hospital mortality, longer mechanical ventilation, and longer MICU stay.

No MeSH data available.


Related in: MedlinePlus