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Primary Ewing's sarcoma of cervical vertebra: An uncommon presentation.

Chhabra S, Singh S, Sethi D, Mahapatra QS - Asian J Neurosurg (2014)

Bottom Line: Ewing's sarcoma is a malignant primary bone tumor primarily seen in the long bones.Primary Ewing's sarcoma of the cranium is quite uncommon occurring in 1% of the cases.Contrast enhanced computed tomography (CECT) revealed a typical moth eaten appearance in the first and second cervical vertebra.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Pt. B.D. Sharma P.G.I.M.S, Rohtak, Haryana, India.

ABSTRACT
Ewing's sarcoma is a malignant primary bone tumor primarily seen in the long bones. Primary Ewing's sarcoma of the cranium is quite uncommon occurring in 1% of the cases. We report the occurrence of this rare lesion in a 24-year-old male presenting with progressively increasing swelling in left mastoid region mimicking a mastoid abscess which was later diagnosed on Fine needle aspiration cytology (FNAC) as a small round cell tumor as Ewing's sarcoma. Contrast enhanced computed tomography (CECT) revealed a typical moth eaten appearance in the first and second cervical vertebra.

No MeSH data available.


Related in: MedlinePlus

(L)-FNAC smear showing small, round cells in loose cohesive clusters, rosettes and dispersed singly (MGG, ×200), (R)-FNAC smear showing small, round cells in loose cohesive clusters and dispersed singly with positivity for cytoplasmic glycogen (PAS, ×400)
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Figure 2: (L)-FNAC smear showing small, round cells in loose cohesive clusters, rosettes and dispersed singly (MGG, ×200), (R)-FNAC smear showing small, round cells in loose cohesive clusters and dispersed singly with positivity for cytoplasmic glycogen (PAS, ×400)

Mentions: Fine needle aspiration of the swelling was done which revealed cellular smears showing small, round cells in loose cohesive clusters, rosettes and dispersed singly with round to irregular bland nuclei, abundant vacuolated cytoplasm positive for cytoplasmic glycogen [Figure 2]. The cells were interspersed with small dark cells with scanty cytoplasm. The cytological diagnosis of small round cell tumor, Ewing's sarcoma was made. A biopsy was performed which revealed sheets of round cells displaying perivascular arrangement at places in a necrotic background. Immunohistochemical evaluation showed diffuse cytoplasmic positivity for CD99, neuron specific enolase (NSE), and vimentin, whereas no expression was seen with LCA (CD45), synaptophysin, chromogranin, and desmin. Based on the imaging findings, primitive small round cell histology and characteristic positivity for CD99, NSE, and vimentin, the diagnosis of Ewing's sarcoma was established.


Primary Ewing's sarcoma of cervical vertebra: An uncommon presentation.

Chhabra S, Singh S, Sethi D, Mahapatra QS - Asian J Neurosurg (2014)

(L)-FNAC smear showing small, round cells in loose cohesive clusters, rosettes and dispersed singly (MGG, ×200), (R)-FNAC smear showing small, round cells in loose cohesive clusters and dispersed singly with positivity for cytoplasmic glycogen (PAS, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129586&req=5

Figure 2: (L)-FNAC smear showing small, round cells in loose cohesive clusters, rosettes and dispersed singly (MGG, ×200), (R)-FNAC smear showing small, round cells in loose cohesive clusters and dispersed singly with positivity for cytoplasmic glycogen (PAS, ×400)
Mentions: Fine needle aspiration of the swelling was done which revealed cellular smears showing small, round cells in loose cohesive clusters, rosettes and dispersed singly with round to irregular bland nuclei, abundant vacuolated cytoplasm positive for cytoplasmic glycogen [Figure 2]. The cells were interspersed with small dark cells with scanty cytoplasm. The cytological diagnosis of small round cell tumor, Ewing's sarcoma was made. A biopsy was performed which revealed sheets of round cells displaying perivascular arrangement at places in a necrotic background. Immunohistochemical evaluation showed diffuse cytoplasmic positivity for CD99, neuron specific enolase (NSE), and vimentin, whereas no expression was seen with LCA (CD45), synaptophysin, chromogranin, and desmin. Based on the imaging findings, primitive small round cell histology and characteristic positivity for CD99, NSE, and vimentin, the diagnosis of Ewing's sarcoma was established.

Bottom Line: Ewing's sarcoma is a malignant primary bone tumor primarily seen in the long bones.Primary Ewing's sarcoma of the cranium is quite uncommon occurring in 1% of the cases.Contrast enhanced computed tomography (CECT) revealed a typical moth eaten appearance in the first and second cervical vertebra.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Pt. B.D. Sharma P.G.I.M.S, Rohtak, Haryana, India.

ABSTRACT
Ewing's sarcoma is a malignant primary bone tumor primarily seen in the long bones. Primary Ewing's sarcoma of the cranium is quite uncommon occurring in 1% of the cases. We report the occurrence of this rare lesion in a 24-year-old male presenting with progressively increasing swelling in left mastoid region mimicking a mastoid abscess which was later diagnosed on Fine needle aspiration cytology (FNAC) as a small round cell tumor as Ewing's sarcoma. Contrast enhanced computed tomography (CECT) revealed a typical moth eaten appearance in the first and second cervical vertebra.

No MeSH data available.


Related in: MedlinePlus