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Thoracic cord compression by extramedullary hematopoiesis in thalassemia.

Hashmi MA, Guha S, Sengupta P, Basu D, Baboo S - Asian J Neurosurg (2014)

Bottom Line: Extramedullary hematopoiesis (EMH) refers to hematopoiesis occurring outside the medulla of bone.EMH can involve liver, spleen, thorax, and lymph nodes.It can involve paraspinal tissues with extension and involvement of spinal canal.

View Article: PubMed Central - PubMed

Affiliation: MRI Section, EKO CT and MRI Scan Centre, Medical College and Hospitals Campus, Kolkata, India.

ABSTRACT
Extramedullary hematopoiesis (EMH) refers to hematopoiesis occurring outside the medulla of bone. It may be physiologic or due to pathological conditions like hematopoietic disorders. EMH can involve liver, spleen, thorax, and lymph nodes. It can involve paraspinal tissues with extension and involvement of spinal canal. In our case, the diagnosis was confirmed by the history of the patient stating underlying hematological condition and by magnetic resonance imaging (MRI) findings showing large soft tissue masses in paraspinal areas with involvement of spinal canal and leading to cord compression.

No MeSH data available.


Related in: MedlinePlus

Saggital T2 weighted images is showing well marginated soft tissue mass lesion involving posterior portion of spinal extradural in location and is causing pressure effect on dorsal cord which is showing post compressive signal changes
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Figure 4: Saggital T2 weighted images is showing well marginated soft tissue mass lesion involving posterior portion of spinal extradural in location and is causing pressure effect on dorsal cord which is showing post compressive signal changes

Mentions: A 28-year-old male diagnosed with Beta thalassemia, presented with back pain and weakness of both lower limbs, which had progressed in recent weeks. On examination, he was paraparetic with muscle strength decreased in both lower limbs. Deep tendon reflexes were exaggerated in both lower limbs. Planter response was extensor on both sides. Liver and spleen was enlarged and his higher mental functions and cranial nerves were normal. On hemoglobin electrophoresis, significant percentage of fetal hemoglobin (HbF) was present. MRI of dorsal spine showed lobulated mass lesion not showing any calcification in paravertebral regions on both sides [Figures 1, 2 and 3]. Extradural mass lesion is also seen involving posterior portion of spinal canal from D4 till D8 level [Figure 4] and is causing pressure effect on dorsal cord with post compressive cord signal changes. Our patient did well with radio-therapy, and the power in limbs gradually increased.


Thoracic cord compression by extramedullary hematopoiesis in thalassemia.

Hashmi MA, Guha S, Sengupta P, Basu D, Baboo S - Asian J Neurosurg (2014)

Saggital T2 weighted images is showing well marginated soft tissue mass lesion involving posterior portion of spinal extradural in location and is causing pressure effect on dorsal cord which is showing post compressive signal changes
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129573&req=5

Figure 4: Saggital T2 weighted images is showing well marginated soft tissue mass lesion involving posterior portion of spinal extradural in location and is causing pressure effect on dorsal cord which is showing post compressive signal changes
Mentions: A 28-year-old male diagnosed with Beta thalassemia, presented with back pain and weakness of both lower limbs, which had progressed in recent weeks. On examination, he was paraparetic with muscle strength decreased in both lower limbs. Deep tendon reflexes were exaggerated in both lower limbs. Planter response was extensor on both sides. Liver and spleen was enlarged and his higher mental functions and cranial nerves were normal. On hemoglobin electrophoresis, significant percentage of fetal hemoglobin (HbF) was present. MRI of dorsal spine showed lobulated mass lesion not showing any calcification in paravertebral regions on both sides [Figures 1, 2 and 3]. Extradural mass lesion is also seen involving posterior portion of spinal canal from D4 till D8 level [Figure 4] and is causing pressure effect on dorsal cord with post compressive cord signal changes. Our patient did well with radio-therapy, and the power in limbs gradually increased.

Bottom Line: Extramedullary hematopoiesis (EMH) refers to hematopoiesis occurring outside the medulla of bone.EMH can involve liver, spleen, thorax, and lymph nodes.It can involve paraspinal tissues with extension and involvement of spinal canal.

View Article: PubMed Central - PubMed

Affiliation: MRI Section, EKO CT and MRI Scan Centre, Medical College and Hospitals Campus, Kolkata, India.

ABSTRACT
Extramedullary hematopoiesis (EMH) refers to hematopoiesis occurring outside the medulla of bone. It may be physiologic or due to pathological conditions like hematopoietic disorders. EMH can involve liver, spleen, thorax, and lymph nodes. It can involve paraspinal tissues with extension and involvement of spinal canal. In our case, the diagnosis was confirmed by the history of the patient stating underlying hematological condition and by magnetic resonance imaging (MRI) findings showing large soft tissue masses in paraspinal areas with involvement of spinal canal and leading to cord compression.

No MeSH data available.


Related in: MedlinePlus