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Update on hypertrophic scar treatment.

Rabello FB, Souza CD, Farina Júnior JA - Clinics (Sao Paulo) (2014)

Bottom Line: Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury.Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability.This review will explore the differences between different types of nonsurgical management of hypertrophic scars, focusing on the indications, uses, mechanisms of action, associations and efficacies of the following therapies: silicone, pressure garments, onion extract, intralesional corticoid injections and bleomycin.

View Article: PubMed Central - PubMed

Affiliation: Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

ABSTRACT
Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury. Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability. The current review will focus on the definition of hypertrophic scars, distinguishing them from keloids and on the various methods for treating hypertrophic scarring that have been described in the literature, including treatments with clearly proven efficiency and therapies with doubtful benefits. Numerous methods have been described for the treatment of abnormal scars, but to date, the optimal treatment method has not been established. This review will explore the differences between different types of nonsurgical management of hypertrophic scars, focusing on the indications, uses, mechanisms of action, associations and efficacies of the following therapies: silicone, pressure garments, onion extract, intralesional corticoid injections and bleomycin.

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The histology of hypertrophic scars is characterized by replacement of the papillary and reticular dermis by scar tissue with prominent vertically oriented blood vessels. The fibrous bundles are parallel and horizontal in the upper dermis. (Masson's trichrome, 100X).
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f3-cln_69p565: The histology of hypertrophic scars is characterized by replacement of the papillary and reticular dermis by scar tissue with prominent vertically oriented blood vessels. The fibrous bundles are parallel and horizontal in the upper dermis. (Masson's trichrome, 100X).

Mentions: The histopathological findings most commonly observed in HTSs are flattening of the epidermis and replacement of the papillary and reticular dermis by scar tissue with prominent vertically oriented blood vessels (Figure 3). In keloids, there is no flattening of the overlying epidermis, no scarring of the papillary dermis, the presence of a significant amount of keloidal collagen, an absence of prominent vertically oriented blood vessels and the presence of a significant disarray of fibrocollagenous fascicles (Figure 4) (15).


Update on hypertrophic scar treatment.

Rabello FB, Souza CD, Farina Júnior JA - Clinics (Sao Paulo) (2014)

The histology of hypertrophic scars is characterized by replacement of the papillary and reticular dermis by scar tissue with prominent vertically oriented blood vessels. The fibrous bundles are parallel and horizontal in the upper dermis. (Masson's trichrome, 100X).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129552&req=5

f3-cln_69p565: The histology of hypertrophic scars is characterized by replacement of the papillary and reticular dermis by scar tissue with prominent vertically oriented blood vessels. The fibrous bundles are parallel and horizontal in the upper dermis. (Masson's trichrome, 100X).
Mentions: The histopathological findings most commonly observed in HTSs are flattening of the epidermis and replacement of the papillary and reticular dermis by scar tissue with prominent vertically oriented blood vessels (Figure 3). In keloids, there is no flattening of the overlying epidermis, no scarring of the papillary dermis, the presence of a significant amount of keloidal collagen, an absence of prominent vertically oriented blood vessels and the presence of a significant disarray of fibrocollagenous fascicles (Figure 4) (15).

Bottom Line: Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury.Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability.This review will explore the differences between different types of nonsurgical management of hypertrophic scars, focusing on the indications, uses, mechanisms of action, associations and efficacies of the following therapies: silicone, pressure garments, onion extract, intralesional corticoid injections and bleomycin.

View Article: PubMed Central - PubMed

Affiliation: Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

ABSTRACT
Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury. Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability. The current review will focus on the definition of hypertrophic scars, distinguishing them from keloids and on the various methods for treating hypertrophic scarring that have been described in the literature, including treatments with clearly proven efficiency and therapies with doubtful benefits. Numerous methods have been described for the treatment of abnormal scars, but to date, the optimal treatment method has not been established. This review will explore the differences between different types of nonsurgical management of hypertrophic scars, focusing on the indications, uses, mechanisms of action, associations and efficacies of the following therapies: silicone, pressure garments, onion extract, intralesional corticoid injections and bleomycin.

Show MeSH
Related in: MedlinePlus