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Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial.

Wanyenze RK, Kamya MR, Fatch R, Mayanja-Kizza H, Baveewo S, Szekeres G, Bangsberg DR, Coates T, Hahn JA - Lancet Glob Health (2013)

Bottom Line: We compared sexual risk behaviour by counselling strategy with a 6·5% non-inferiority margin.Linkage to care did not have a significant effect on mortality or receipt of co-trimoxazole.Time to treatment in men with CD4 cell counts of 250 cells per μL or fewer was lower for enhanced linkage versus standard linkage (adjusted HR 0·60, 95% CI 0·41-0·87) and time to HIV care was decreased among women (0·80, 0·66-0·96).

View Article: PubMed Central - PubMed

Affiliation: Department of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda. Electronic address: rwanyenze@hotmail.com.

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Related in: MedlinePlus

Kaplan-Meier curves of time to start of antiretroviral therapy in patients with CD4 cell count less than 250 cells per μLIn men (A) and women (B). Adjusted for baseline CD4 cell count and employment.
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Figure 2: Kaplan-Meier curves of time to start of antiretroviral therapy in patients with CD4 cell count less than 250 cells per μLIn men (A) and women (B). Adjusted for baseline CD4 cell count and employment.

Mentions: We recorded no difference between linkage groups for mortality, receipt of prophylaxis for opportunistic infection, or receipt of HIV care (table 3). However, we report significant interactions (p<0·10) for two variables: time to HIV care was significantly different in women only (adjusted HR 0·80, 95% CI 0·66–0·96) and the effect of linkage to care on time to start of antiretroviral treatment was significantly different in men only (0·60, 0·41–0·87). In men with CD4 cell count of 250 cells per μL or less, median time to start of antiretroviral treatment was 107 days versus 192 days for enhanced linkage versus standard linkage (figure 2). In a post-hoc analysis, we recorded no difference between abbreviated and traditional HIV counselling and testing in time to HIV care, controlling for linkage to care group (data not shown).


Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial.

Wanyenze RK, Kamya MR, Fatch R, Mayanja-Kizza H, Baveewo S, Szekeres G, Bangsberg DR, Coates T, Hahn JA - Lancet Glob Health (2013)

Kaplan-Meier curves of time to start of antiretroviral therapy in patients with CD4 cell count less than 250 cells per μLIn men (A) and women (B). Adjusted for baseline CD4 cell count and employment.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129546&req=5

Figure 2: Kaplan-Meier curves of time to start of antiretroviral therapy in patients with CD4 cell count less than 250 cells per μLIn men (A) and women (B). Adjusted for baseline CD4 cell count and employment.
Mentions: We recorded no difference between linkage groups for mortality, receipt of prophylaxis for opportunistic infection, or receipt of HIV care (table 3). However, we report significant interactions (p<0·10) for two variables: time to HIV care was significantly different in women only (adjusted HR 0·80, 95% CI 0·66–0·96) and the effect of linkage to care on time to start of antiretroviral treatment was significantly different in men only (0·60, 0·41–0·87). In men with CD4 cell count of 250 cells per μL or less, median time to start of antiretroviral treatment was 107 days versus 192 days for enhanced linkage versus standard linkage (figure 2). In a post-hoc analysis, we recorded no difference between abbreviated and traditional HIV counselling and testing in time to HIV care, controlling for linkage to care group (data not shown).

Bottom Line: We compared sexual risk behaviour by counselling strategy with a 6·5% non-inferiority margin.Linkage to care did not have a significant effect on mortality or receipt of co-trimoxazole.Time to treatment in men with CD4 cell counts of 250 cells per μL or fewer was lower for enhanced linkage versus standard linkage (adjusted HR 0·60, 95% CI 0·41-0·87) and time to HIV care was decreased among women (0·80, 0·66-0·96).

View Article: PubMed Central - PubMed

Affiliation: Department of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda. Electronic address: rwanyenze@hotmail.com.

Show MeSH
Related in: MedlinePlus