Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial.
Bottom Line: We compared sexual risk behaviour by counselling strategy with a 6·5% non-inferiority margin.Linkage to care did not have a significant effect on mortality or receipt of co-trimoxazole.Time to treatment in men with CD4 cell counts of 250 cells per μL or fewer was lower for enhanced linkage versus standard linkage (adjusted HR 0·60, 95% CI 0·41-0·87) and time to HIV care was decreased among women (0·80, 0·66-0·96).
Affiliation: Department of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda. Electronic address: firstname.lastname@example.org.Show MeSH
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Mentions: We recorded no difference between linkage groups for mortality, receipt of prophylaxis for opportunistic infection, or receipt of HIV care (table 3). However, we report significant interactions (p<0·10) for two variables: time to HIV care was significantly different in women only (adjusted HR 0·80, 95% CI 0·66–0·96) and the effect of linkage to care on time to start of antiretroviral treatment was significantly different in men only (0·60, 0·41–0·87). In men with CD4 cell count of 250 cells per μL or less, median time to start of antiretroviral treatment was 107 days versus 192 days for enhanced linkage versus standard linkage (figure 2). In a post-hoc analysis, we recorded no difference between abbreviated and traditional HIV counselling and testing in time to HIV care, controlling for linkage to care group (data not shown).
Affiliation: Department of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda. Electronic address: email@example.com.