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Association between bone mineral density and clinical consequences: cross-sectional study of Korean postmenopausal women in an orthopaedic outpatient clinic.

Lee JH, Lee YH, Moon SH, TOP Study Gro - J. Korean Med. Sci. (2014)

Bottom Line: The distribution of the normal, osteopenia and osteoporosis group was 25.9%, 37.0%, and 37.2% in lumbar spine, and 31.4%, 45.3%, and 23.3% in femur neck, respectively.The femur neck and total hip BMDs were significantly lower in hip fracture group (0.646 g/cm(2) and 0.643 g/cm(2), respectively) and wrist fracture group (0.661 g/cm(2) and 0.712 g/cm(2), respectively) than in subjects without fracture (0.721 g/cm(2) and 0.712 g/cm(2), respectively).In Korean postmenopausal women, the prevalence of osteoporosis and vertebral, hip and wrist fracture increase and quality of life decreases with lower BMD.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, College of Medicine, Seoul National University, Seoul, Korea. ; Department of Orthopaedic Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

ABSTRACT
This study is to identify the characteristics of BMD and the related clinical consequences through a nationwide, consecutive, cross-sectional study. A total of 1,281 postmenopausal women was enrolled nationwide and underwent measurement for BMD using dual energy x-ray absorptiometry. Following the T-spine and L-spine plane radiography, they were evaluated for vertebral fracture by a semi-quantitative method using the Genant's method. Relationship between BMD and osteoporotic fracture and a degree of deformity in vertebral fracture, treatment history in osteoporosis and the EQ-5D was analyzed. The distribution of the normal, osteopenia and osteoporosis group was 25.9%, 37.0%, and 37.2% in lumbar spine, and 31.4%, 45.3%, and 23.3% in femur neck, respectively. BMD in subjects with symptomatic or asymptomatic vertebral fracture was significantly lower than those without fracture. The femur neck and total hip BMDs were significantly lower in hip fracture group (0.646 g/cm(2) and 0.643 g/cm(2), respectively) and wrist fracture group (0.661 g/cm(2) and 0.712 g/cm(2), respectively) than in subjects without fracture (0.721 g/cm(2) and 0.712 g/cm(2), respectively). The BMD was significantly lower with more severe degree of deformity in vertebral fracture and lower scores in mobility, usual activities and pain/discomfort of the EQ-5D. In Korean postmenopausal women, the prevalence of osteoporosis and vertebral, hip and wrist fracture increase and quality of life decreases with lower BMD.

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The incidence of osteoporotic vertebral compression fracture by T-score. With decreasing T-score, the prevalence of vertebral compression fracture increase.
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Figure 2: The incidence of osteoporotic vertebral compression fracture by T-score. With decreasing T-score, the prevalence of vertebral compression fracture increase.

Mentions: As a result of evaluating vertebral compression fracture by dividing the T-scores into the normal group, osteopenia group and osteoporosis group (T≥-1.0, -2.5<T<-1.0, and T≤-2.5), the incidence of vertebral compression fracture tended to decrease with increasing T-score (Fig. 2). In addition, it was statistically significant that the mean BMD values in the L-spine, femur neck and total hip were lower in subjects with osteoporotic vertebral fracture than those without fracture, (P<0.001 for all three), regardless of the presence of back pain (Fig. 3). The mean T-scores in the L-spine, femur neck and total hip were lower in subjects with osteoporotic vertebral fracture than those without fracture, (P<0.001 for all three), regardless of the presence of pain (Fig. 3).


Association between bone mineral density and clinical consequences: cross-sectional study of Korean postmenopausal women in an orthopaedic outpatient clinic.

Lee JH, Lee YH, Moon SH, TOP Study Gro - J. Korean Med. Sci. (2014)

The incidence of osteoporotic vertebral compression fracture by T-score. With decreasing T-score, the prevalence of vertebral compression fracture increase.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129210&req=5

Figure 2: The incidence of osteoporotic vertebral compression fracture by T-score. With decreasing T-score, the prevalence of vertebral compression fracture increase.
Mentions: As a result of evaluating vertebral compression fracture by dividing the T-scores into the normal group, osteopenia group and osteoporosis group (T≥-1.0, -2.5<T<-1.0, and T≤-2.5), the incidence of vertebral compression fracture tended to decrease with increasing T-score (Fig. 2). In addition, it was statistically significant that the mean BMD values in the L-spine, femur neck and total hip were lower in subjects with osteoporotic vertebral fracture than those without fracture, (P<0.001 for all three), regardless of the presence of back pain (Fig. 3). The mean T-scores in the L-spine, femur neck and total hip were lower in subjects with osteoporotic vertebral fracture than those without fracture, (P<0.001 for all three), regardless of the presence of pain (Fig. 3).

Bottom Line: The distribution of the normal, osteopenia and osteoporosis group was 25.9%, 37.0%, and 37.2% in lumbar spine, and 31.4%, 45.3%, and 23.3% in femur neck, respectively.The femur neck and total hip BMDs were significantly lower in hip fracture group (0.646 g/cm(2) and 0.643 g/cm(2), respectively) and wrist fracture group (0.661 g/cm(2) and 0.712 g/cm(2), respectively) than in subjects without fracture (0.721 g/cm(2) and 0.712 g/cm(2), respectively).In Korean postmenopausal women, the prevalence of osteoporosis and vertebral, hip and wrist fracture increase and quality of life decreases with lower BMD.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, College of Medicine, Seoul National University, Seoul, Korea. ; Department of Orthopaedic Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

ABSTRACT
This study is to identify the characteristics of BMD and the related clinical consequences through a nationwide, consecutive, cross-sectional study. A total of 1,281 postmenopausal women was enrolled nationwide and underwent measurement for BMD using dual energy x-ray absorptiometry. Following the T-spine and L-spine plane radiography, they were evaluated for vertebral fracture by a semi-quantitative method using the Genant's method. Relationship between BMD and osteoporotic fracture and a degree of deformity in vertebral fracture, treatment history in osteoporosis and the EQ-5D was analyzed. The distribution of the normal, osteopenia and osteoporosis group was 25.9%, 37.0%, and 37.2% in lumbar spine, and 31.4%, 45.3%, and 23.3% in femur neck, respectively. BMD in subjects with symptomatic or asymptomatic vertebral fracture was significantly lower than those without fracture. The femur neck and total hip BMDs were significantly lower in hip fracture group (0.646 g/cm(2) and 0.643 g/cm(2), respectively) and wrist fracture group (0.661 g/cm(2) and 0.712 g/cm(2), respectively) than in subjects without fracture (0.721 g/cm(2) and 0.712 g/cm(2), respectively). The BMD was significantly lower with more severe degree of deformity in vertebral fracture and lower scores in mobility, usual activities and pain/discomfort of the EQ-5D. In Korean postmenopausal women, the prevalence of osteoporosis and vertebral, hip and wrist fracture increase and quality of life decreases with lower BMD.

Show MeSH
Related in: MedlinePlus