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Effects of first-time overnight CPAP therapy for increasing the complexity of the patient's physiological system.

Wu HT, Chen HR, Pan WY, Liu CC, Su MC, Lin MC - Comput Math Methods Med (2014)

Bottom Line: The results show that the participants in Group 1 exhibited significant changes in normalized low-frequency power/normalized high-frequency power (nLF/nHF) (0.72 ± 0.09 versus 1.11 ± 0.11, P = 0.006) values before and after the PSG study.By contrast, the participants in Group 2 showed no significant changes in the 3 indicators.Regarding the sMSE indicator, Group 2 patients exhibited significant increases in the sMSE.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, National Dong Hwa University, Hualien 97401, Taiwan.

ABSTRACT
Studies regarding the effects of short-term continuous positive airway pressure (CPAP) therapy are not sufficient. A total of 35 patients with moderate to severe untreated OSA were divided into 2 groups. Group 1 comprised 22 patients who underwent polysomnography (PSG) for one night, and Group 2 comprised 13 patients who received PSG combined with CPAP therapy. To evaluate the influence of receiving CPAP therapy for one night, we measured 5 min wrist pulse signals before and after the experiment to assess heart rate variability, as well as novel short time multiscale entropy (sMSE) indicator that examines complexity in physiological signals. The results show that the participants in Group 1 exhibited significant changes in normalized low-frequency power/normalized high-frequency power (nLF/nHF) (0.72 ± 0.09 versus 1.11 ± 0.11, P = 0.006) values before and after the PSG study. By contrast, the participants in Group 2 showed no significant changes in the 3 indicators. Regarding the sMSE indicator, Group 2 patients exhibited significant increases in the sMSE. CPAP therapy administered for one night can reduce the sympathovagal imbalance in patients with moderate to severe untreated OSA and increase the complexity of the patient's physiological system, thereby reflecting their overall improved health.

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Related in: MedlinePlus

Patients with moderate to severe OSA were divided into 2 groups, and their autonomic activity changes before and after the sleep experiment were compared using the nLF and nHF indicators. (a) Group 1 received PSG measurements only and (b) Group 2 received PSG measurements and CPAP therapy simultaneously.
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fig1: Patients with moderate to severe OSA were divided into 2 groups, and their autonomic activity changes before and after the sleep experiment were compared using the nLF and nHF indicators. (a) Group 1 received PSG measurements only and (b) Group 2 received PSG measurements and CPAP therapy simultaneously.

Mentions: Figure 1 shows the changes in nLF and nHF for Groups 1 and 2 before and after sleep. Figure 1(a) shows that Group 1 experienced a significant pre- to postexperiment increase in the nLF indicator (0.39 ± 0.03 versus 0.49 ± 0.03, P = 0.005), whereas nHF declined significantly (0.61 ± 0.03 versus 0.51 ± 0.03, P = 0.005). Figure 1(b) shows that Group 2 did not exhibit significant pre- and postexperiment changes in the nLF (0.43 ± 0.05 versus 0.44 ± 0.04, P = 0.701) and nHF (0.57 ± 0.05 versus 0.56 ± 0.04, P = 0.743) indicators.


Effects of first-time overnight CPAP therapy for increasing the complexity of the patient's physiological system.

Wu HT, Chen HR, Pan WY, Liu CC, Su MC, Lin MC - Comput Math Methods Med (2014)

Patients with moderate to severe OSA were divided into 2 groups, and their autonomic activity changes before and after the sleep experiment were compared using the nLF and nHF indicators. (a) Group 1 received PSG measurements only and (b) Group 2 received PSG measurements and CPAP therapy simultaneously.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4129133&req=5

fig1: Patients with moderate to severe OSA were divided into 2 groups, and their autonomic activity changes before and after the sleep experiment were compared using the nLF and nHF indicators. (a) Group 1 received PSG measurements only and (b) Group 2 received PSG measurements and CPAP therapy simultaneously.
Mentions: Figure 1 shows the changes in nLF and nHF for Groups 1 and 2 before and after sleep. Figure 1(a) shows that Group 1 experienced a significant pre- to postexperiment increase in the nLF indicator (0.39 ± 0.03 versus 0.49 ± 0.03, P = 0.005), whereas nHF declined significantly (0.61 ± 0.03 versus 0.51 ± 0.03, P = 0.005). Figure 1(b) shows that Group 2 did not exhibit significant pre- and postexperiment changes in the nLF (0.43 ± 0.05 versus 0.44 ± 0.04, P = 0.701) and nHF (0.57 ± 0.05 versus 0.56 ± 0.04, P = 0.743) indicators.

Bottom Line: The results show that the participants in Group 1 exhibited significant changes in normalized low-frequency power/normalized high-frequency power (nLF/nHF) (0.72 ± 0.09 versus 1.11 ± 0.11, P = 0.006) values before and after the PSG study.By contrast, the participants in Group 2 showed no significant changes in the 3 indicators.Regarding the sMSE indicator, Group 2 patients exhibited significant increases in the sMSE.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical Engineering, National Dong Hwa University, Hualien 97401, Taiwan.

ABSTRACT
Studies regarding the effects of short-term continuous positive airway pressure (CPAP) therapy are not sufficient. A total of 35 patients with moderate to severe untreated OSA were divided into 2 groups. Group 1 comprised 22 patients who underwent polysomnography (PSG) for one night, and Group 2 comprised 13 patients who received PSG combined with CPAP therapy. To evaluate the influence of receiving CPAP therapy for one night, we measured 5 min wrist pulse signals before and after the experiment to assess heart rate variability, as well as novel short time multiscale entropy (sMSE) indicator that examines complexity in physiological signals. The results show that the participants in Group 1 exhibited significant changes in normalized low-frequency power/normalized high-frequency power (nLF/nHF) (0.72 ± 0.09 versus 1.11 ± 0.11, P = 0.006) values before and after the PSG study. By contrast, the participants in Group 2 showed no significant changes in the 3 indicators. Regarding the sMSE indicator, Group 2 patients exhibited significant increases in the sMSE. CPAP therapy administered for one night can reduce the sympathovagal imbalance in patients with moderate to severe untreated OSA and increase the complexity of the patient's physiological system, thereby reflecting their overall improved health.

Show MeSH
Related in: MedlinePlus