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Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies.

Liang SQ, Chen XL, Deng JM, Wei X, Gong C, Chen ZR, Wang ZB - PLoS ONE (2014)

Bottom Line: However, the results are inconsistent.The results showed that not all of the SNPs were associated with asthma in the overall population.Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies  = 2, case  = 314, control  = 237) in an analysis stratified by ethnicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

ABSTRACT

Background and objective: A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.

Methods: A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.

Results: Arg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies  = 2, case  = 314, control  = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies  = 11, case  = 1693, control  =  502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies  = 11, case  = 1693, control  = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case  = 3160, control  = 3433).

Conclusions: None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.

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Related in: MedlinePlus

Forest plots of cumulative meta-analysis of Gln27Glu (rs1042714) in association with asthma by published year dominant model comparison.
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pone-0104488-g014: Forest plots of cumulative meta-analysis of Gln27Glu (rs1042714) in association with asthma by published year dominant model comparison.

Mentions: Cumulative analysis of the association between Arg16Gly and Gln27Glu polymorphisms and the risk of asthma was performed after sorting by publication date. As shown in Figures 10 to 13, for Arg16Gly, there was a stable trend in the estimated risk effect in the dominant model comparison from 2009 to 2012 and in the allelic comparison from 1993 to 2012. As shown in Figures 14 to 17, for Gln27Glu, there was a trend toward no significant association over time in all genetic model comparisons.


Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies.

Liang SQ, Chen XL, Deng JM, Wei X, Gong C, Chen ZR, Wang ZB - PLoS ONE (2014)

Forest plots of cumulative meta-analysis of Gln27Glu (rs1042714) in association with asthma by published year dominant model comparison.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4128804&req=5

pone-0104488-g014: Forest plots of cumulative meta-analysis of Gln27Glu (rs1042714) in association with asthma by published year dominant model comparison.
Mentions: Cumulative analysis of the association between Arg16Gly and Gln27Glu polymorphisms and the risk of asthma was performed after sorting by publication date. As shown in Figures 10 to 13, for Arg16Gly, there was a stable trend in the estimated risk effect in the dominant model comparison from 2009 to 2012 and in the allelic comparison from 1993 to 2012. As shown in Figures 14 to 17, for Gln27Glu, there was a trend toward no significant association over time in all genetic model comparisons.

Bottom Line: However, the results are inconsistent.The results showed that not all of the SNPs were associated with asthma in the overall population.Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies  = 2, case  = 314, control  = 237) in an analysis stratified by ethnicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

ABSTRACT

Background and objective: A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.

Methods: A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.

Results: Arg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies  = 2, case  = 314, control  = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies  = 11, case  = 1693, control  =  502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies  = 11, case  = 1693, control  = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case  = 3160, control  = 3433).

Conclusions: None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.

Show MeSH
Related in: MedlinePlus