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A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype.

Dalleck LC, Van Guilder GP, Richardson TB, Bredle DL, Janot JM - Diabetes Metab Syndr Obes (2014)

Bottom Line: Metabolic syndrome components were measured in 332 adults (190 women, 142 men) before and after a supervised 14-week community-based exercise program designed to reduce cardiometabolic risk factors.Compared with the lowest quartiles of relative energy expenditure and change in fitness, participants in the highest quartiles were 11.6 (95% confidence interval: 2.1-65.4; P<0.05) and 7.5 (95% confidence interval: 1.5-37.5; P<0.05) times more likely to transition from MAO to MHO, respectively.MAO adults who engaged in higher volumes of exercise and experienced the greatest increase in fitness were significantly more likely to become metabolically healthy.

View Article: PubMed Central - PubMed

Affiliation: Recreation, Exercise, and Sport Science Department, Western State Colorado University, Gunnison, CO, USA ; Department of Kinesiology, University of Wisconsin-Eau Claire, Eau Claire, WI, USA.

ABSTRACT

Background: Lower habitual physical activity and poor cardiorespiratory fitness are common features of the metabolically abnormal obese (MAO) phenotype that contribute to increased cardiovascular disease risk. The aims of the present study were to determine 1) whether community-based exercise training transitions MAO adults to metabolically healthy, and 2) whether the odds of transition to metabolically healthy were larger for obese individuals who performed higher volumes of exercise and/or experienced greater increases in fitness.

Methods and results: Metabolic syndrome components were measured in 332 adults (190 women, 142 men) before and after a supervised 14-week community-based exercise program designed to reduce cardiometabolic risk factors. Obese (body mass index ≥30 kg · m(2)) adults with two to four metabolic syndrome components were classified as MAO, whereas those with no or one component were classified as metabolically healthy but obese (MHO). After community exercise, 27/68 (40%) MAO individuals (P<0.05) transitioned to metabolically healthy, increasing the total number of MHO persons by 73% (from 37 to 64). Compared with the lowest quartiles of relative energy expenditure and change in fitness, participants in the highest quartiles were 11.6 (95% confidence interval: 2.1-65.4; P<0.05) and 7.5 (95% confidence interval: 1.5-37.5; P<0.05) times more likely to transition from MAO to MHO, respectively.

Conclusion: Community-based exercise transitions MAO adults to metabolically healthy. MAO adults who engaged in higher volumes of exercise and experienced the greatest increase in fitness were significantly more likely to become metabolically healthy. Community exercise may be an effective model for primary prevention of cardiovascular disease.

No MeSH data available.


Related in: MedlinePlus

Changes in point prevalence of metabolic syndrome risk factors before and after community exercise in the metabolically abnormal obese (A), metabolically healthy obese (B), metabolically abnormal nonobese (C), and metabolically healthy nonobese (D) subgroups who did not transition.Notes: *P<0.05 versus before community exercise. Data analyzed using Crosstabs Procedure, Chi-square difference testing.Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein.
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f3-dmso-7-369: Changes in point prevalence of metabolic syndrome risk factors before and after community exercise in the metabolically abnormal obese (A), metabolically healthy obese (B), metabolically abnormal nonobese (C), and metabolically healthy nonobese (D) subgroups who did not transition.Notes: *P<0.05 versus before community exercise. Data analyzed using Crosstabs Procedure, Chi-square difference testing.Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein.

Mentions: Although a considerable portion of MAO people transitioned to a healthy obese phenotype, a number of MAO individuals (n=41) did not. Baseline and postprogram health outcomes for MAO individuals who did not transition are presented in Table 2. Similar to the MAO adults who transitioned to metabolically healthy (Table 1), MAO individuals who did not transition demonstrated significant mean reductions in all health outcomes after community exercise, with the exception of BMI, body mass, and LDL cholesterol (Table 2). Nevertheless, as shown in Figure 3A, there was no significant change in the point prevalence of MetS components after community exercise in this MAO subgroup.


A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype.

Dalleck LC, Van Guilder GP, Richardson TB, Bredle DL, Janot JM - Diabetes Metab Syndr Obes (2014)

Changes in point prevalence of metabolic syndrome risk factors before and after community exercise in the metabolically abnormal obese (A), metabolically healthy obese (B), metabolically abnormal nonobese (C), and metabolically healthy nonobese (D) subgroups who did not transition.Notes: *P<0.05 versus before community exercise. Data analyzed using Crosstabs Procedure, Chi-square difference testing.Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4128798&req=5

f3-dmso-7-369: Changes in point prevalence of metabolic syndrome risk factors before and after community exercise in the metabolically abnormal obese (A), metabolically healthy obese (B), metabolically abnormal nonobese (C), and metabolically healthy nonobese (D) subgroups who did not transition.Notes: *P<0.05 versus before community exercise. Data analyzed using Crosstabs Procedure, Chi-square difference testing.Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein.
Mentions: Although a considerable portion of MAO people transitioned to a healthy obese phenotype, a number of MAO individuals (n=41) did not. Baseline and postprogram health outcomes for MAO individuals who did not transition are presented in Table 2. Similar to the MAO adults who transitioned to metabolically healthy (Table 1), MAO individuals who did not transition demonstrated significant mean reductions in all health outcomes after community exercise, with the exception of BMI, body mass, and LDL cholesterol (Table 2). Nevertheless, as shown in Figure 3A, there was no significant change in the point prevalence of MetS components after community exercise in this MAO subgroup.

Bottom Line: Metabolic syndrome components were measured in 332 adults (190 women, 142 men) before and after a supervised 14-week community-based exercise program designed to reduce cardiometabolic risk factors.Compared with the lowest quartiles of relative energy expenditure and change in fitness, participants in the highest quartiles were 11.6 (95% confidence interval: 2.1-65.4; P<0.05) and 7.5 (95% confidence interval: 1.5-37.5; P<0.05) times more likely to transition from MAO to MHO, respectively.MAO adults who engaged in higher volumes of exercise and experienced the greatest increase in fitness were significantly more likely to become metabolically healthy.

View Article: PubMed Central - PubMed

Affiliation: Recreation, Exercise, and Sport Science Department, Western State Colorado University, Gunnison, CO, USA ; Department of Kinesiology, University of Wisconsin-Eau Claire, Eau Claire, WI, USA.

ABSTRACT

Background: Lower habitual physical activity and poor cardiorespiratory fitness are common features of the metabolically abnormal obese (MAO) phenotype that contribute to increased cardiovascular disease risk. The aims of the present study were to determine 1) whether community-based exercise training transitions MAO adults to metabolically healthy, and 2) whether the odds of transition to metabolically healthy were larger for obese individuals who performed higher volumes of exercise and/or experienced greater increases in fitness.

Methods and results: Metabolic syndrome components were measured in 332 adults (190 women, 142 men) before and after a supervised 14-week community-based exercise program designed to reduce cardiometabolic risk factors. Obese (body mass index ≥30 kg · m(2)) adults with two to four metabolic syndrome components were classified as MAO, whereas those with no or one component were classified as metabolically healthy but obese (MHO). After community exercise, 27/68 (40%) MAO individuals (P<0.05) transitioned to metabolically healthy, increasing the total number of MHO persons by 73% (from 37 to 64). Compared with the lowest quartiles of relative energy expenditure and change in fitness, participants in the highest quartiles were 11.6 (95% confidence interval: 2.1-65.4; P<0.05) and 7.5 (95% confidence interval: 1.5-37.5; P<0.05) times more likely to transition from MAO to MHO, respectively.

Conclusion: Community-based exercise transitions MAO adults to metabolically healthy. MAO adults who engaged in higher volumes of exercise and experienced the greatest increase in fitness were significantly more likely to become metabolically healthy. Community exercise may be an effective model for primary prevention of cardiovascular disease.

No MeSH data available.


Related in: MedlinePlus