Structural and functional aspects relating to cost and benefit of rich club organization in the human cerebral cortex.
Bottom Line: Recent findings have demonstrated that a small set of highly connected brain regions may play a central role in enabling efficient communication between cortical regions, together forming a densely interconnected "rich club." However, the density and spatial layout of the rich club also suggest that it constitutes a costly feature of brain architecture.Our findings suggest that rich club regions and rich club connections exhibit high levels of wiring volume, high levels of white matter organization, high levels of metabolic energy usage, long maturational trajectories, more variable regional time series, and more inter-regional functional couplings.The high cost of the rich club may, however, be offset by significant functional benefits that the rich club confers to the brain network as a whole.
Affiliation: Department of Psychiatry, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands.Show MeSH
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Mentions: Definition of the rich club allows for the classification of the nodes of the network into rich club and non-rich club nodes (van den Heuvel and Sporns 2011). In turn, categorization of the nodes allows for the classification of the network connections into 3 classes: “rich club” connections, linking rich club nodes to each other; “feeder” connections linking rich club nodes to non-rich club nodes; and “local” connections linking non-rich club nodes to each other. Figure 1B presents a schematic illustration of the 2 classes of nodes and the 3 classes of connections.Figure 1.
Affiliation: Department of Psychiatry, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands.