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Systemic vascular resistance in cirrhosis: a predictor of severity?

Gaduputi V, Abdulsamad M, Sakam S, Abbas N, Tariq H, Ihimoyan A - Hepat Med (2014)

Bottom Line: Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L).In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models.We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia.

View Article: PubMed Central - PubMed

Affiliation: Bronx Lebanon Hospital Center, Department of Medicine, Bronx, NY, USA.

ABSTRACT

Background: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modifications.

Methods: Patients with cirrhosis, who were admitted to hospital with decompensation (as defined by development of ascites, hepatic encephalopathy, and variceal bleeding) and underwent echocardiography were included in this study. Laboratory data required for computing MELD score, serum bilirubin, serum creatinine, international normalized ratio, and serum sodium were collected for every patient. We tabulated hemodynamic and echocardiography parameters that enabled calculation of SVR. We analyzed the correlation between SVR and each of the individual prognostic scores.

Results: A total of 771 patients with a diagnosis of decompensated cirrhosis were included in the study. Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L). In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models. However, these correlations were not seen in patients with normonatremia.

Conclusion: We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia.

No MeSH data available.


Related in: MedlinePlus

No significant correlation was found between SVR and iMELD scores in the normonatremic patients (P=0.4660; 95% confidence interval of slope −0.02668, 0.05832; R2=0.001053).Abbreviations: SVR, systemic vascular resistance; MELD, Model for End‐stage Liver Disease; iMELD, integrated MELD.
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f6-hmer-6-095: No significant correlation was found between SVR and iMELD scores in the normonatremic patients (P=0.4660; 95% confidence interval of slope −0.02668, 0.05832; R2=0.001053).Abbreviations: SVR, systemic vascular resistance; MELD, Model for End‐stage Liver Disease; iMELD, integrated MELD.

Mentions: There was a significant inverse correlation between the SVR and iMELD scores in patients with hyponatremia (P=0.0266) but not in those with normonatremia (P=0.4660) (Figures 5 and 6). There was a significant inverse correlation between the SVR and MESO scores in patients with hyponatremia (P=0.0356) but not in those with normonatremia (P=0.3036; Figures 7 and 8). There was also a significant inverse correlation between the SVR and UKELD scores in patients with hyponatremia (P=0.0225) but not in those with normonatremia (P=0.1380; Figures 9 and 10).


Systemic vascular resistance in cirrhosis: a predictor of severity?

Gaduputi V, Abdulsamad M, Sakam S, Abbas N, Tariq H, Ihimoyan A - Hepat Med (2014)

No significant correlation was found between SVR and iMELD scores in the normonatremic patients (P=0.4660; 95% confidence interval of slope −0.02668, 0.05832; R2=0.001053).Abbreviations: SVR, systemic vascular resistance; MELD, Model for End‐stage Liver Disease; iMELD, integrated MELD.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4128691&req=5

f6-hmer-6-095: No significant correlation was found between SVR and iMELD scores in the normonatremic patients (P=0.4660; 95% confidence interval of slope −0.02668, 0.05832; R2=0.001053).Abbreviations: SVR, systemic vascular resistance; MELD, Model for End‐stage Liver Disease; iMELD, integrated MELD.
Mentions: There was a significant inverse correlation between the SVR and iMELD scores in patients with hyponatremia (P=0.0266) but not in those with normonatremia (P=0.4660) (Figures 5 and 6). There was a significant inverse correlation between the SVR and MESO scores in patients with hyponatremia (P=0.0356) but not in those with normonatremia (P=0.3036; Figures 7 and 8). There was also a significant inverse correlation between the SVR and UKELD scores in patients with hyponatremia (P=0.0225) but not in those with normonatremia (P=0.1380; Figures 9 and 10).

Bottom Line: Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L).In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models.We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia.

View Article: PubMed Central - PubMed

Affiliation: Bronx Lebanon Hospital Center, Department of Medicine, Bronx, NY, USA.

ABSTRACT

Background: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modifications.

Methods: Patients with cirrhosis, who were admitted to hospital with decompensation (as defined by development of ascites, hepatic encephalopathy, and variceal bleeding) and underwent echocardiography were included in this study. Laboratory data required for computing MELD score, serum bilirubin, serum creatinine, international normalized ratio, and serum sodium were collected for every patient. We tabulated hemodynamic and echocardiography parameters that enabled calculation of SVR. We analyzed the correlation between SVR and each of the individual prognostic scores.

Results: A total of 771 patients with a diagnosis of decompensated cirrhosis were included in the study. Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L). In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models. However, these correlations were not seen in patients with normonatremia.

Conclusion: We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia.

No MeSH data available.


Related in: MedlinePlus