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Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction.

Xu H, Li H, Liu J, Zhu D, Wang Z, Chen A, Zhao Q - PLoS ONE (2014)

Bottom Line: Searching in PubMed retrieved all eligible articles.The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19).However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

ABSTRACT
A number of case-control studies have been conducted to clarify the association between ApoE polymorphisms and myocardial infarction (MI); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence. Searching in PubMed retrieved all eligible articles. A total of 33 studies were included in this meta-analysis, including 18752 MI cases and 18963 controls. The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21). Our results suggested that the ε4 allele of ApoE is a risk factor for the development of MI and the ε2 allele of ApoE is a protective factor in the development of MI.

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Forest plot for ApoE gene polymorphism and MI risk in the ε4 allele frequency analysis.
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pone-0104608-g003: Forest plot for ApoE gene polymorphism and MI risk in the ε4 allele frequency analysis.

Mentions: The meta-analysis of the included studies showed that there was significant association between the ApoE gene polymorphism and MI. The results showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70–0.87, Figure 2) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10–1.20, Figure 3). The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68–0.90, Figure S1), and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69–0.89, Figure S4), and an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12–1.41, Figure S2) in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15–2.19, Figure S3) and in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12–1.32, Figure S5). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of ε3 allele (OR = 0.99, 95% CI = 0.96–1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40–1.32); ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99–1.21). The detailed results are shown in Table 2. Cumulative analysis further confirmed the results (Figure 4 and Figure S6).


Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction.

Xu H, Li H, Liu J, Zhu D, Wang Z, Chen A, Zhao Q - PLoS ONE (2014)

Forest plot for ApoE gene polymorphism and MI risk in the ε4 allele frequency analysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4128680&req=5

pone-0104608-g003: Forest plot for ApoE gene polymorphism and MI risk in the ε4 allele frequency analysis.
Mentions: The meta-analysis of the included studies showed that there was significant association between the ApoE gene polymorphism and MI. The results showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70–0.87, Figure 2) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10–1.20, Figure 3). The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68–0.90, Figure S1), and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69–0.89, Figure S4), and an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12–1.41, Figure S2) in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15–2.19, Figure S3) and in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12–1.32, Figure S5). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of ε3 allele (OR = 0.99, 95% CI = 0.96–1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40–1.32); ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99–1.21). The detailed results are shown in Table 2. Cumulative analysis further confirmed the results (Figure 4 and Figure S6).

Bottom Line: Searching in PubMed retrieved all eligible articles.The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19).However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

ABSTRACT
A number of case-control studies have been conducted to clarify the association between ApoE polymorphisms and myocardial infarction (MI); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence. Searching in PubMed retrieved all eligible articles. A total of 33 studies were included in this meta-analysis, including 18752 MI cases and 18963 controls. The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21). Our results suggested that the ε4 allele of ApoE is a risk factor for the development of MI and the ε2 allele of ApoE is a protective factor in the development of MI.

Show MeSH
Related in: MedlinePlus