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Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction.

Xu H, Li H, Liu J, Zhu D, Wang Z, Chen A, Zhao Q - PLoS ONE (2014)

Bottom Line: Searching in PubMed retrieved all eligible articles.The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19).However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

ABSTRACT
A number of case-control studies have been conducted to clarify the association between ApoE polymorphisms and myocardial infarction (MI); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence. Searching in PubMed retrieved all eligible articles. A total of 33 studies were included in this meta-analysis, including 18752 MI cases and 18963 controls. The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21). Our results suggested that the ε4 allele of ApoE is a risk factor for the development of MI and the ε2 allele of ApoE is a protective factor in the development of MI.

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Related in: MedlinePlus

Flowchart of the study selection.
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pone-0104608-g001: Flowchart of the study selection.

Mentions: One hundred and thirty two articles were retrieved from PubMed, 79 of which were excluded after screening the titles and abstracts (58 were irrelevant studies, 13 were reviews and eight were not published in English or Chinese). Fifty-three articles were selected for detailed assessment, which excluded a further 20 articles (seven were not case-control studies, eight had no usable data (no case and control numbers according to the genotypes) and five were not about MI). Finally, 33 studies were included in this meta-analysis, which included 18752 MI cases and 18963 controls. The detailed selection procedure is shown in Figure 1. There were three studies did not follow the HWE. The detailed characteristics of the included studies are shown in Table 1. The present study met the PRISMA statement requirements (Checklist S1 and Figure 1).


Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction.

Xu H, Li H, Liu J, Zhu D, Wang Z, Chen A, Zhao Q - PLoS ONE (2014)

Flowchart of the study selection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4128680&req=5

pone-0104608-g001: Flowchart of the study selection.
Mentions: One hundred and thirty two articles were retrieved from PubMed, 79 of which were excluded after screening the titles and abstracts (58 were irrelevant studies, 13 were reviews and eight were not published in English or Chinese). Fifty-three articles were selected for detailed assessment, which excluded a further 20 articles (seven were not case-control studies, eight had no usable data (no case and control numbers according to the genotypes) and five were not about MI). Finally, 33 studies were included in this meta-analysis, which included 18752 MI cases and 18963 controls. The detailed selection procedure is shown in Figure 1. There were three studies did not follow the HWE. The detailed characteristics of the included studies are shown in Table 1. The present study met the PRISMA statement requirements (Checklist S1 and Figure 1).

Bottom Line: Searching in PubMed retrieved all eligible articles.The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19).However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

ABSTRACT
A number of case-control studies have been conducted to clarify the association between ApoE polymorphisms and myocardial infarction (MI); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence. Searching in PubMed retrieved all eligible articles. A total of 33 studies were included in this meta-analysis, including 18752 MI cases and 18963 controls. The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21). Our results suggested that the ε4 allele of ApoE is a risk factor for the development of MI and the ε2 allele of ApoE is a protective factor in the development of MI.

Show MeSH
Related in: MedlinePlus