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Increased low-frequency oscillation amplitude of sensorimotor cortex associated with the severity of structural impairment in cervical myelopathy.

Zhou F, Gong H, Liu X, Wu L, Luk KD, Hu Y - PLoS ONE (2014)

Bottom Line: ALFF measurements were performed in the SMC, a key brain network likely to impaired or reorganized patients with CM.Compared with healthy subjects, increased amplitude of cortical low-frequency oscillations (LFO) was observed in the right precentral gyrus, right postcentral gyrus, and left supplementary motor area.Furthermore, increased z-ALFF values in the right precentral gyrus and right postcentral gyrus correlated with decreased fractional anisotropy values at the C2 level, which indicated increased intrinsic neuronal activity in the SMC corresponding to the structural impairment in the spinal cord of patients with CM.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, the First Affiliated Hospital, NanChang University, Nanchang, Jiangxi, China; Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

ABSTRACT
Decreases in metabolites and increased motor-related, but decreased sensory-related activation of the sensorimotor cortex (SMC) have been observed in patients with cervical myelopathy (CM) using advanced MRI techniques. However, the nature of intrinsic neuronal activity in the SMC, and the relationship between cerebral function and structural damage of the spinal cord in patients with CM are not fully understood. The purpose of this study was to assess intrinsic neuronal activity by calculating the regional amplitude of low frequency fluctuations (ALFF) using resting-state functional MRI (rs-fMRI), and correlations with clinical and imaging indices. Nineteen patients and 19 age- and sex-matched healthy subjects underwent rs-fMRI scans. ALFF measurements were performed in the SMC, a key brain network likely to impaired or reorganized patients with CM. Compared with healthy subjects, increased amplitude of cortical low-frequency oscillations (LFO) was observed in the right precentral gyrus, right postcentral gyrus, and left supplementary motor area. Furthermore, increased z-ALFF values in the right precentral gyrus and right postcentral gyrus correlated with decreased fractional anisotropy values at the C2 level, which indicated increased intrinsic neuronal activity in the SMC corresponding to the structural impairment in the spinal cord of patients with CM. These findings suggest a complex and diverging relationship of cortical functional reorganization and distal spinal anatomical compression in patients with CM and, thus, add important information in understanding how spinal cord integrity may be a factor in the intrinsic covariance of spontaneous low-frequency fluctuations of BOLD signals involved in cortical plasticity.

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Two sample t-test analysis, and function of brain-structure in spinal cord relationship analysis.(a) ALFF/LFO amplitude differences between the CM and healthy subjects groups (CSM > Controls, p<0.05, AlphaSim corrected; cluster size ≥20). Warm colors indicate ALFF/LFO amplitude increases in patients with CM. T-score bars are shown on the right. (b) The correlation analysis results between the z-ALFF values of the right PreG, right PostG and the FA values at the C2 level of the CM patients. (C =  Cervical vertebra; CM =  Cervical myelopathy; P =  Posterior; PreG =  Precentral gyrus; PostG =  Postcentral gyrus; SMA =  Supplementary Motor Area; R =  Right hemisphere).
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pone-0104442-g001: Two sample t-test analysis, and function of brain-structure in spinal cord relationship analysis.(a) ALFF/LFO amplitude differences between the CM and healthy subjects groups (CSM > Controls, p<0.05, AlphaSim corrected; cluster size ≥20). Warm colors indicate ALFF/LFO amplitude increases in patients with CM. T-score bars are shown on the right. (b) The correlation analysis results between the z-ALFF values of the right PreG, right PostG and the FA values at the C2 level of the CM patients. (C =  Cervical vertebra; CM =  Cervical myelopathy; P =  Posterior; PreG =  Precentral gyrus; PostG =  Postcentral gyrus; SMA =  Supplementary Motor Area; R =  Right hemisphere).

Mentions: Figure 1a shows group-level CM vs. control group ALFF differences within the SMC. Compared with the control group, the CM group had a significantly higher ALFF (red-yellow spots in Figure 1a) in the right precentral gyrus (PreG), right postcentral gyrus (PostG), and left supplementary motor area (SMA). The t-value and the cluster size of the CM vs. control group ALFF differences are listed in Table 2.


Increased low-frequency oscillation amplitude of sensorimotor cortex associated with the severity of structural impairment in cervical myelopathy.

Zhou F, Gong H, Liu X, Wu L, Luk KD, Hu Y - PLoS ONE (2014)

Two sample t-test analysis, and function of brain-structure in spinal cord relationship analysis.(a) ALFF/LFO amplitude differences between the CM and healthy subjects groups (CSM > Controls, p<0.05, AlphaSim corrected; cluster size ≥20). Warm colors indicate ALFF/LFO amplitude increases in patients with CM. T-score bars are shown on the right. (b) The correlation analysis results between the z-ALFF values of the right PreG, right PostG and the FA values at the C2 level of the CM patients. (C =  Cervical vertebra; CM =  Cervical myelopathy; P =  Posterior; PreG =  Precentral gyrus; PostG =  Postcentral gyrus; SMA =  Supplementary Motor Area; R =  Right hemisphere).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4128667&req=5

pone-0104442-g001: Two sample t-test analysis, and function of brain-structure in spinal cord relationship analysis.(a) ALFF/LFO amplitude differences between the CM and healthy subjects groups (CSM > Controls, p<0.05, AlphaSim corrected; cluster size ≥20). Warm colors indicate ALFF/LFO amplitude increases in patients with CM. T-score bars are shown on the right. (b) The correlation analysis results between the z-ALFF values of the right PreG, right PostG and the FA values at the C2 level of the CM patients. (C =  Cervical vertebra; CM =  Cervical myelopathy; P =  Posterior; PreG =  Precentral gyrus; PostG =  Postcentral gyrus; SMA =  Supplementary Motor Area; R =  Right hemisphere).
Mentions: Figure 1a shows group-level CM vs. control group ALFF differences within the SMC. Compared with the control group, the CM group had a significantly higher ALFF (red-yellow spots in Figure 1a) in the right precentral gyrus (PreG), right postcentral gyrus (PostG), and left supplementary motor area (SMA). The t-value and the cluster size of the CM vs. control group ALFF differences are listed in Table 2.

Bottom Line: ALFF measurements were performed in the SMC, a key brain network likely to impaired or reorganized patients with CM.Compared with healthy subjects, increased amplitude of cortical low-frequency oscillations (LFO) was observed in the right precentral gyrus, right postcentral gyrus, and left supplementary motor area.Furthermore, increased z-ALFF values in the right precentral gyrus and right postcentral gyrus correlated with decreased fractional anisotropy values at the C2 level, which indicated increased intrinsic neuronal activity in the SMC corresponding to the structural impairment in the spinal cord of patients with CM.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, the First Affiliated Hospital, NanChang University, Nanchang, Jiangxi, China; Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

ABSTRACT
Decreases in metabolites and increased motor-related, but decreased sensory-related activation of the sensorimotor cortex (SMC) have been observed in patients with cervical myelopathy (CM) using advanced MRI techniques. However, the nature of intrinsic neuronal activity in the SMC, and the relationship between cerebral function and structural damage of the spinal cord in patients with CM are not fully understood. The purpose of this study was to assess intrinsic neuronal activity by calculating the regional amplitude of low frequency fluctuations (ALFF) using resting-state functional MRI (rs-fMRI), and correlations with clinical and imaging indices. Nineteen patients and 19 age- and sex-matched healthy subjects underwent rs-fMRI scans. ALFF measurements were performed in the SMC, a key brain network likely to impaired or reorganized patients with CM. Compared with healthy subjects, increased amplitude of cortical low-frequency oscillations (LFO) was observed in the right precentral gyrus, right postcentral gyrus, and left supplementary motor area. Furthermore, increased z-ALFF values in the right precentral gyrus and right postcentral gyrus correlated with decreased fractional anisotropy values at the C2 level, which indicated increased intrinsic neuronal activity in the SMC corresponding to the structural impairment in the spinal cord of patients with CM. These findings suggest a complex and diverging relationship of cortical functional reorganization and distal spinal anatomical compression in patients with CM and, thus, add important information in understanding how spinal cord integrity may be a factor in the intrinsic covariance of spontaneous low-frequency fluctuations of BOLD signals involved in cortical plasticity.

Show MeSH
Related in: MedlinePlus