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Elevated level of plasma endothelin-1 in patients with atrial septal defect.

Komar M, Podolec J, Płazak W, Stępniewski J, Sobień B, Tomkiewicz-Pająk L, Przewłocki T, Podolec P - Cardiovasc Ultrasound (2014)

Bottom Line: ET-1 levels at peripheral artery and vein in ASD patients were significantly higher than in the volunteers (p < 0.0001).The level of ET-1 in ASD patients is elevated in compare to healthy subject.2.Elevated level of ET-1 in patients with ASD is associated with right heart enlargement.4.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Jagiellonian University, Str, Prądnicka 80, 31-202 Krakow, Poland. moni_s@interia.pl.

ABSTRACT

Background: The study aimed to assess the level of plasma Endothelin-1 (ET-1) in patients before and after transcatheter closure of atrial septal defect (ASD) and to evaluate the usefulness of measuring ET-1 levels for the diagnosis and selection of candidates for ASD closure.

Methods: 80 patients (55 F, 25 M), mean age 42,2 ± 11,5 years were enrolled for an attempt at ASD closure. A group of 19 healthy volunteers, (12 F, 7 M) mean age 39.2 ± 9.15 served as controls. All ASD patients underwent: clinical and echocardiographic study and cardiopulmonary exercise test. ET-1 levels were measured before and after closure. Whole blood was collected from femoral artery and vein and from pulmonary artery during cardiac catheterization.

Results: ET-1 levels at peripheral artery and vein in ASD patients were significantly higher than in the volunteers (p < 0.0001). The ASD subjects with highest ET-1 level presented the larger area of right ventricle and right atrium and higher pulmonary artery systolic pressure(p < 0.05). The ASD subjects with lower ET-1 level demonstrated longer time of exercise and higher peak oxygen consumption (p < 0.05). There was a decrease of ET-1 at peripheral artery (5.128 ± 8.8 vs. 2.22 ± 6.2; p < 0.001) and at peripheral vein (4.401 ± 3.33 vs. 2.05 ± 1.35; p < 0.001) within 48 hours after ASD closure, as compared to the baseline data. After 6 and 12 months farther drop in ET-1 level was observed.

Conclusions: 1. The level of ET-1 in ASD patients is elevated in compare to healthy subject.2. The significant reduction of ET-1 level is observed after percutaneous closure of ASD.3. Elevated level of ET-1 in patients with ASD is associated with right heart enlargement.4. Measurements of ET-1 may be a supplemental diagnostic tool and may be helpful in establishing indications for defect closure.

Show MeSH
ROC curves for selected parameters [VO2peak(ml/kg/min) – red, FVC (%) – green, VO2AT% – black, TAT – blue] and cut-off values.
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Related In: Results  -  Collection

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Figure 5: ROC curves for selected parameters [VO2peak(ml/kg/min) – red, FVC (%) – green, VO2AT% – black, TAT – blue] and cut-off values.

Mentions: Higher ET-1 levels before closure don’t predict higher pulmonary artery pressure/resistances after closure.ROC curves for selected parameters influencing ET-1 levels and meta-analysis using the Peto method are depicted in Figures 4, 5 and 6.


Elevated level of plasma endothelin-1 in patients with atrial septal defect.

Komar M, Podolec J, Płazak W, Stępniewski J, Sobień B, Tomkiewicz-Pająk L, Przewłocki T, Podolec P - Cardiovasc Ultrasound (2014)

ROC curves for selected parameters [VO2peak(ml/kg/min) – red, FVC (%) – green, VO2AT% – black, TAT – blue] and cut-off values.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4128543&req=5

Figure 5: ROC curves for selected parameters [VO2peak(ml/kg/min) – red, FVC (%) – green, VO2AT% – black, TAT – blue] and cut-off values.
Mentions: Higher ET-1 levels before closure don’t predict higher pulmonary artery pressure/resistances after closure.ROC curves for selected parameters influencing ET-1 levels and meta-analysis using the Peto method are depicted in Figures 4, 5 and 6.

Bottom Line: ET-1 levels at peripheral artery and vein in ASD patients were significantly higher than in the volunteers (p < 0.0001).The level of ET-1 in ASD patients is elevated in compare to healthy subject.2.Elevated level of ET-1 in patients with ASD is associated with right heart enlargement.4.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Jagiellonian University, Str, Prądnicka 80, 31-202 Krakow, Poland. moni_s@interia.pl.

ABSTRACT

Background: The study aimed to assess the level of plasma Endothelin-1 (ET-1) in patients before and after transcatheter closure of atrial septal defect (ASD) and to evaluate the usefulness of measuring ET-1 levels for the diagnosis and selection of candidates for ASD closure.

Methods: 80 patients (55 F, 25 M), mean age 42,2 ± 11,5 years were enrolled for an attempt at ASD closure. A group of 19 healthy volunteers, (12 F, 7 M) mean age 39.2 ± 9.15 served as controls. All ASD patients underwent: clinical and echocardiographic study and cardiopulmonary exercise test. ET-1 levels were measured before and after closure. Whole blood was collected from femoral artery and vein and from pulmonary artery during cardiac catheterization.

Results: ET-1 levels at peripheral artery and vein in ASD patients were significantly higher than in the volunteers (p < 0.0001). The ASD subjects with highest ET-1 level presented the larger area of right ventricle and right atrium and higher pulmonary artery systolic pressure(p < 0.05). The ASD subjects with lower ET-1 level demonstrated longer time of exercise and higher peak oxygen consumption (p < 0.05). There was a decrease of ET-1 at peripheral artery (5.128 ± 8.8 vs. 2.22 ± 6.2; p < 0.001) and at peripheral vein (4.401 ± 3.33 vs. 2.05 ± 1.35; p < 0.001) within 48 hours after ASD closure, as compared to the baseline data. After 6 and 12 months farther drop in ET-1 level was observed.

Conclusions: 1. The level of ET-1 in ASD patients is elevated in compare to healthy subject.2. The significant reduction of ET-1 level is observed after percutaneous closure of ASD.3. Elevated level of ET-1 in patients with ASD is associated with right heart enlargement.4. Measurements of ET-1 may be a supplemental diagnostic tool and may be helpful in establishing indications for defect closure.

Show MeSH