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Diabetic foot risk factors in type 2 diabetes patients: a cross-sectional case control study.

Nehring P, Mrozikiewicz-Rakowska B, Krzyżewska M, Sobczyk-Kopcioł A, Płoski R, Broda G, Karnafel W - J Diabetes Metab Disord (2014)

Bottom Line: Study was conducted in Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland.In statistical analysis a logistic regression model, U Mann-Whitney's and t-Student test were used.The onset of type 2 diabetes in healthy subjects was increased by weight (OR = 1.035; 95% CI: 1.024-1.046; p = 0.00001), WC (OR = 1.075; 95% CI: 1.055-1.096; p = 00001), hip circumference (OR = 1.03; 95% CI: 1.01-1.05; p = 0.005), overweight defined with body mass index (BMI) above 24,9 kg/m(2) (OR = 2.49; 95% CI: 1.77-3.51; p = 0.00001) and hyperlipidaemia (OR = 3.53; 95% CI: 2.57-4.84; p = 0.00001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, ul. Banacha 1a, Warsaw 02-097, Poland.

ABSTRACT

Background: Diabetic foot is a serious condition in patients with a long lasting diabetes mellitus. Diabetic foot treated improperly may lead not only to delayed ulceration healing, generalized inflammation, unnecessary surgical intervention, but also to the lower limb amputation. The aim of this study was to compare diabetic foot risk factors in population with type 2 diabetes and risk factors for diabetes in healthy subjects.

Methods: The study included 900 subjects: 145 with diabetic foot, 293 with type 2 diabetes without diabetic foot and 462 healthy controls matched in terms of mean age, gender structure and cardiovascular diseases absence. Study was conducted in Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland. In statistical analysis a logistic regression model, U Mann-Whitney's and t-Student test were used.

Results: The binomial logit models analysis showed that the risk of diabetic foot in patients with type 2 diabetes was decreased by patient's age (odds ratio [OR] = 0.94; 95% confidence interval [CI]: 0.92-0.96; p = 0.00001) and hyperlipidaemia (OR = 0.54; 95% CI: 0.36-0.81; p = 0.01). In contrast, male gender (OR = 2.83; 95% CI: 1.86-4.28; p = 0.00001) diabetes duration (OR = 1.04; 95% CI: 1.03-1.06; p = 0.0003), weight (OR = 1.04; 95% CI: 1.03-1.06; p = 0.00001), height (OR = 1.08; 95% CI: 1.05-1.11; p = 0.00001) and waist circumference (OR = 1.028; 95% CI: 1.007-1.050; p = 0.006) increase the risk of diabetic foot. The onset of type 2 diabetes in healthy subjects was increased by weight (OR = 1.035; 95% CI: 1.024-1.046; p = 0.00001), WC (OR = 1.075; 95% CI: 1.055-1.096; p = 00001), hip circumference (OR = 1.03; 95% CI: 1.01-1.05; p = 0.005), overweight defined with body mass index (BMI) above 24,9 kg/m(2) (OR = 2.49; 95% CI: 1.77-3.51; p = 0.00001) and hyperlipidaemia (OR = 3.53; 95% CI: 2.57-4.84; p = 0.00001).

Conclusions: Risk factors for Type 2 diabetes and diabetic foot are only partially common. Study proved that patients who are prone to developing diabetic foot experience different risk factors than patients who are at risk of diabetes. Identification of relationship between diabetic foot and diabetes risk factors in appropriate groups may help clinicians to focus on certain factors in diabetic foot prevention.

No MeSH data available.


Related in: MedlinePlus

Number of BMI over and below 24.9 kg/m2 in patients with type 2 diabetes and in healthy controls.
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Figure 2: Number of BMI over and below 24.9 kg/m2 in patients with type 2 diabetes and in healthy controls.

Mentions: In the presented study, the comparison between type 2 diabetes group and healthy subjects showed that factors increasing the risk of diabetes were weight (mean 80.72 v 73.09 kg, OR = 1.035, 95% CI: 1.024-1.046, p = 0.00001), WC (mean 104.55 v 91.62 cm, OR = 1.075, 95% CI: 1.055-1.096, p = 0.00001), hips circumference (mean 108.47 v 105.00 cm, OR = 1.03, 95% CI: 1.01-1.05, p = 0.005), overweight defined as BMI over 24.9 kg/m2 (OR = 2.49, 95% CI: 1.77-3.51, p = 0.00001) (Figure 2).


Diabetic foot risk factors in type 2 diabetes patients: a cross-sectional case control study.

Nehring P, Mrozikiewicz-Rakowska B, Krzyżewska M, Sobczyk-Kopcioł A, Płoski R, Broda G, Karnafel W - J Diabetes Metab Disord (2014)

Number of BMI over and below 24.9 kg/m2 in patients with type 2 diabetes and in healthy controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4128535&req=5

Figure 2: Number of BMI over and below 24.9 kg/m2 in patients with type 2 diabetes and in healthy controls.
Mentions: In the presented study, the comparison between type 2 diabetes group and healthy subjects showed that factors increasing the risk of diabetes were weight (mean 80.72 v 73.09 kg, OR = 1.035, 95% CI: 1.024-1.046, p = 0.00001), WC (mean 104.55 v 91.62 cm, OR = 1.075, 95% CI: 1.055-1.096, p = 0.00001), hips circumference (mean 108.47 v 105.00 cm, OR = 1.03, 95% CI: 1.01-1.05, p = 0.005), overweight defined as BMI over 24.9 kg/m2 (OR = 2.49, 95% CI: 1.77-3.51, p = 0.00001) (Figure 2).

Bottom Line: Study was conducted in Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland.In statistical analysis a logistic regression model, U Mann-Whitney's and t-Student test were used.The onset of type 2 diabetes in healthy subjects was increased by weight (OR = 1.035; 95% CI: 1.024-1.046; p = 0.00001), WC (OR = 1.075; 95% CI: 1.055-1.096; p = 00001), hip circumference (OR = 1.03; 95% CI: 1.01-1.05; p = 0.005), overweight defined with body mass index (BMI) above 24,9 kg/m(2) (OR = 2.49; 95% CI: 1.77-3.51; p = 0.00001) and hyperlipidaemia (OR = 3.53; 95% CI: 2.57-4.84; p = 0.00001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, ul. Banacha 1a, Warsaw 02-097, Poland.

ABSTRACT

Background: Diabetic foot is a serious condition in patients with a long lasting diabetes mellitus. Diabetic foot treated improperly may lead not only to delayed ulceration healing, generalized inflammation, unnecessary surgical intervention, but also to the lower limb amputation. The aim of this study was to compare diabetic foot risk factors in population with type 2 diabetes and risk factors for diabetes in healthy subjects.

Methods: The study included 900 subjects: 145 with diabetic foot, 293 with type 2 diabetes without diabetic foot and 462 healthy controls matched in terms of mean age, gender structure and cardiovascular diseases absence. Study was conducted in Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland. In statistical analysis a logistic regression model, U Mann-Whitney's and t-Student test were used.

Results: The binomial logit models analysis showed that the risk of diabetic foot in patients with type 2 diabetes was decreased by patient's age (odds ratio [OR] = 0.94; 95% confidence interval [CI]: 0.92-0.96; p = 0.00001) and hyperlipidaemia (OR = 0.54; 95% CI: 0.36-0.81; p = 0.01). In contrast, male gender (OR = 2.83; 95% CI: 1.86-4.28; p = 0.00001) diabetes duration (OR = 1.04; 95% CI: 1.03-1.06; p = 0.0003), weight (OR = 1.04; 95% CI: 1.03-1.06; p = 0.00001), height (OR = 1.08; 95% CI: 1.05-1.11; p = 0.00001) and waist circumference (OR = 1.028; 95% CI: 1.007-1.050; p = 0.006) increase the risk of diabetic foot. The onset of type 2 diabetes in healthy subjects was increased by weight (OR = 1.035; 95% CI: 1.024-1.046; p = 0.00001), WC (OR = 1.075; 95% CI: 1.055-1.096; p = 00001), hip circumference (OR = 1.03; 95% CI: 1.01-1.05; p = 0.005), overweight defined with body mass index (BMI) above 24,9 kg/m(2) (OR = 2.49; 95% CI: 1.77-3.51; p = 0.00001) and hyperlipidaemia (OR = 3.53; 95% CI: 2.57-4.84; p = 0.00001).

Conclusions: Risk factors for Type 2 diabetes and diabetic foot are only partially common. Study proved that patients who are prone to developing diabetic foot experience different risk factors than patients who are at risk of diabetes. Identification of relationship between diabetic foot and diabetes risk factors in appropriate groups may help clinicians to focus on certain factors in diabetic foot prevention.

No MeSH data available.


Related in: MedlinePlus