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Subclinical visuospatial impairment in Parkinson's disease: the role of Basal Ganglia and limbic system.

Caproni S, Muti M, Di Renzo A, Principi M, Caputo N, Calabresi P, Tambasco N - Front Neurol (2014)

Bottom Line: Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations.Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed.In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere.

View Article: PubMed Central - PubMed

Affiliation: Clinica Neurologica, Azienda Ospedaliera - Università di Perugia , Italy.

ABSTRACT

Background: Visual perception deficits are a recurrent manifestation in Parkinson's disease (PD). Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations. The aim of the present study was to investigate the salient aspects of visual perception in cognitively unimpaired PD patients.

Methods: Eleven right-handed non-demented right-sided onset PD patients without visuospatial impairment or hallucinations and 11 healthy controls were studied with functional magnetic resonance imaging while performing a specific visuoperceptual/visuospatial paradigm that allowed to highlight the specific process underlying visuospatial judgment.

Results: Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed. In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere.

Conclusions: We found that both loss of efficiency and compensatory mechanisms occur in PD patients, providing further insight into the pathophysiological role of the functional alterations of basal ganglia and limbic structures in the impairment of visuoperceptual and visuospatial functions observed in PD.

No MeSH data available.


Related in: MedlinePlus

[PD patients (VS > VP)] > [Controls (VS > VP)]. The over-activations of right dorso-lateral-prefrontal cortex (A), right (B), and left (C) posterior parietal cortex observed in patients, compared to controls, for the second-level analysis VS > VP are shown. Colors bar range for F-score: 2–17.95.
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Figure 2: [PD patients (VS > VP)] > [Controls (VS > VP)]. The over-activations of right dorso-lateral-prefrontal cortex (A), right (B), and left (C) posterior parietal cortex observed in patients, compared to controls, for the second-level analysis VS > VP are shown. Colors bar range for F-score: 2–17.95.

Mentions: Compared to controls, for the second-level between-group comparison VS > VP PD patients had an over-activation of the right dorso-lateral prefrontal cortex (DLPFC), defined as the sum of part of Broadman areas 9 and 46, and bilateral posterior parietal cortex (PPC), defined as the sum of Broadman areas 7 and 40 (particularly in the right hemisphere) (Figure 2, Table 2). Whereas, controls had a greater activation of the right insula, left putamen, bilateral caudate (particularly in the head), and right hippocampus (Figure 3, Table 2).


Subclinical visuospatial impairment in Parkinson's disease: the role of Basal Ganglia and limbic system.

Caproni S, Muti M, Di Renzo A, Principi M, Caputo N, Calabresi P, Tambasco N - Front Neurol (2014)

[PD patients (VS > VP)] > [Controls (VS > VP)]. The over-activations of right dorso-lateral-prefrontal cortex (A), right (B), and left (C) posterior parietal cortex observed in patients, compared to controls, for the second-level analysis VS > VP are shown. Colors bar range for F-score: 2–17.95.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4128219&req=5

Figure 2: [PD patients (VS > VP)] > [Controls (VS > VP)]. The over-activations of right dorso-lateral-prefrontal cortex (A), right (B), and left (C) posterior parietal cortex observed in patients, compared to controls, for the second-level analysis VS > VP are shown. Colors bar range for F-score: 2–17.95.
Mentions: Compared to controls, for the second-level between-group comparison VS > VP PD patients had an over-activation of the right dorso-lateral prefrontal cortex (DLPFC), defined as the sum of part of Broadman areas 9 and 46, and bilateral posterior parietal cortex (PPC), defined as the sum of Broadman areas 7 and 40 (particularly in the right hemisphere) (Figure 2, Table 2). Whereas, controls had a greater activation of the right insula, left putamen, bilateral caudate (particularly in the head), and right hippocampus (Figure 3, Table 2).

Bottom Line: Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations.Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed.In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere.

View Article: PubMed Central - PubMed

Affiliation: Clinica Neurologica, Azienda Ospedaliera - Università di Perugia , Italy.

ABSTRACT

Background: Visual perception deficits are a recurrent manifestation in Parkinson's disease (PD). Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations. The aim of the present study was to investigate the salient aspects of visual perception in cognitively unimpaired PD patients.

Methods: Eleven right-handed non-demented right-sided onset PD patients without visuospatial impairment or hallucinations and 11 healthy controls were studied with functional magnetic resonance imaging while performing a specific visuoperceptual/visuospatial paradigm that allowed to highlight the specific process underlying visuospatial judgment.

Results: Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed. In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere.

Conclusions: We found that both loss of efficiency and compensatory mechanisms occur in PD patients, providing further insight into the pathophysiological role of the functional alterations of basal ganglia and limbic structures in the impairment of visuoperceptual and visuospatial functions observed in PD.

No MeSH data available.


Related in: MedlinePlus