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Pneumococcal colonisation density: a new marker for disease severity in HIV-infected adults with pneumonia.

Albrich WC, Madhi SA, Adrian PV, van Niekerk N, Telles JN, Ebrahim N, Messaoudi M, Paranhos-Baccalà G, Giersdorf S, Vernet G, Mueller B, Klugman KP - BMJ Open (2014)

Bottom Line: A high genomic load of Pneumococcus from blood or cerebrospinal fluid has been associated with increased mortality.In addition to its previously reported role as a diagnostic tool for pneumococcal pneumonia, quantitative nasopharyngeal colonisation density also correlates with mortality and prognostic biomarkers.It may also be useful as a severity marker for pneumococcal pneumonia in HIV-infected adults.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital St Gallen, St Gallen, Switzerland Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa.

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Association of nasopharyngeal colonisation density with bacteraemia and death. Nasopharyngeal colonisation density according to bacteraemia (either positive blood cultures or positive lytA real-time (rt) PCR from whole blood) and survival in HIV-infected patients with pneumococcal pneumonia. +/° represent the mean; length of the box represents the IQR between the 25th and 75th centiles; horizontal line in the box represents median; whiskers represent minimum and maximum values.
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BMJOPEN2014005953F1: Association of nasopharyngeal colonisation density with bacteraemia and death. Nasopharyngeal colonisation density according to bacteraemia (either positive blood cultures or positive lytA real-time (rt) PCR from whole blood) and survival in HIV-infected patients with pneumococcal pneumonia. +/° represent the mean; length of the box represents the IQR between the 25th and 75th centiles; horizontal line in the box represents median; whiskers represent minimum and maximum values.

Mentions: Presence of pneumococci in blood (by culture or whole blood lytA rtPCR) among cases with SP-CAP was associated with a higher pneumococcal NP colonisation density than if SP-CAP was non-bacteraemic (6.6 vs 5.6 log10 copies/mL, p=0.03; figure 1). Similarly, growth of S. pneumoniae from blood cultures was associated with higher NP colonisation density among patients with SP-CAP than those without (7.1 vs 6.1 log10 copies/mL, p=0.04).


Pneumococcal colonisation density: a new marker for disease severity in HIV-infected adults with pneumonia.

Albrich WC, Madhi SA, Adrian PV, van Niekerk N, Telles JN, Ebrahim N, Messaoudi M, Paranhos-Baccalà G, Giersdorf S, Vernet G, Mueller B, Klugman KP - BMJ Open (2014)

Association of nasopharyngeal colonisation density with bacteraemia and death. Nasopharyngeal colonisation density according to bacteraemia (either positive blood cultures or positive lytA real-time (rt) PCR from whole blood) and survival in HIV-infected patients with pneumococcal pneumonia. +/° represent the mean; length of the box represents the IQR between the 25th and 75th centiles; horizontal line in the box represents median; whiskers represent minimum and maximum values.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127937&req=5

BMJOPEN2014005953F1: Association of nasopharyngeal colonisation density with bacteraemia and death. Nasopharyngeal colonisation density according to bacteraemia (either positive blood cultures or positive lytA real-time (rt) PCR from whole blood) and survival in HIV-infected patients with pneumococcal pneumonia. +/° represent the mean; length of the box represents the IQR between the 25th and 75th centiles; horizontal line in the box represents median; whiskers represent minimum and maximum values.
Mentions: Presence of pneumococci in blood (by culture or whole blood lytA rtPCR) among cases with SP-CAP was associated with a higher pneumococcal NP colonisation density than if SP-CAP was non-bacteraemic (6.6 vs 5.6 log10 copies/mL, p=0.03; figure 1). Similarly, growth of S. pneumoniae from blood cultures was associated with higher NP colonisation density among patients with SP-CAP than those without (7.1 vs 6.1 log10 copies/mL, p=0.04).

Bottom Line: A high genomic load of Pneumococcus from blood or cerebrospinal fluid has been associated with increased mortality.In addition to its previously reported role as a diagnostic tool for pneumococcal pneumonia, quantitative nasopharyngeal colonisation density also correlates with mortality and prognostic biomarkers.It may also be useful as a severity marker for pneumococcal pneumonia in HIV-infected adults.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital St Gallen, St Gallen, Switzerland Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa.

Show MeSH
Related in: MedlinePlus