Physical activity and risk of fatty liver in people with different levels of alcohol consumption: a prospective cohort study.
Bottom Line: They were grouped into never-moderate alcohol drinkers (n=7803) and heavy alcohol drinkers (n=2343) and followed until 2013.In propensity-adjusted models, these significant associations still remained.Physical activity had an independent protective effect on incident fatty liver only in the never-moderate alcohol drinkers, and the preventive effect increased with higher frequencies and intensities of physical activity.
Affiliation: Physical Fitness Research Institute, Meiji Yasuda Life Foundation of Health and Welfare, Hachioji, Tokyo, Japan.Show MeSH
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Mentions: We used data from the Meiji Yasuda Longitudinal Study, a prospective cohort study based on annual health check-ups conducted in Meiji Yasuda Shinjuku Medical Center in Shinjuku Ward, Tokyo, Japan. The majority of patients were employees and their spouses, with employers providing financial support for the annual health check-ups. This popular method of providing medical services in Japan is called ‘a human dock’. It is also an important source for research participants and data including fatty liver studies.671424Figure 1 shows the flow of participants through the study. We used 2005–2007 survey data (n=25 056, aged 18 years or older) as our baseline data. Of these people, 2541 individuals were excluded due to the lack of an ultrasound confirming their fatty liver and 2365 due to incomplete data. We further excluded 1328 because they had histories of liver disease, including hepatitis B or C, cirrhosis and hepatic haemangioma, they were using drugs associated with hepatic disease or they had antibodies to hepatitis B or C. We excluded 3832 individuals because they had fatty liver disease at the baseline. Furthermore, 4844 individuals were excluded because they could not be followed for at least 1 year. We had a final tally of 10 146 participants. These participants were followed through their annual health check-ups until fatty liver disease had been diagnosed or until the end of 2013. When a participant we were following did not attend an annual check-up, we used all available follow-up data. All participants provided informed consent.
Affiliation: Physical Fitness Research Institute, Meiji Yasuda Life Foundation of Health and Welfare, Hachioji, Tokyo, Japan.