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Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature.

Almadani N, Alsaad KO, Al-Matrafi H, Al Hadab A, Abdullah N, AlKushi A - Urol Ann (2014)

Bottom Line: Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood.We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder.In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City and College of Medicine, King Saud University for Health Sciences, Riyadh, Saudi Arabia.

ABSTRACT
Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood. They are generally classified into either skeletal osteosarcomas, or their and rare soft tissue counterpart. The occurrence of osteosarcoma in the urinary bladder (UB) following radiotherapy is exceedingly rare. To the best of our knowledge, only two cases of radiation-related urinary bladder osteosarcoma have been published; we herein describe another case of an 85-year-old man who developed post radiotherapy chondroblastic osteosarcoma of the urinary bladder four years following initial surgical resection and radiotherapy for bladder urothelial carcinoma. We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder. In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

No MeSH data available.


Related in: MedlinePlus

Osteosarcoma of the urinary bladder with malignant osteoid formation and chondroid differentiation (H and E, ×200)
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Figure 3: Osteosarcoma of the urinary bladder with malignant osteoid formation and chondroid differentiation (H and E, ×200)

Mentions: Light microscopic examination was performed on 5 μ thick sections from formaldehyde-fixed, paraffin embedded tissue, and showed malignant spindle cell proliferation with neoplastic osteoid formation, surrounded by abundant malignant chondroid matrix [Figure 3]. There was no evidence of urothelial carcinoma in situ, or invasive papillary urothelial carcinoma. A panel of immunohistochemical stains was performed. The neoplastic spindle cells showed strong and diffuse immunoreactivity to vimentin, while the chondroid component of the tumor was positive for S100-protein. There was no staining for pan-cytokeratin, CK7, CK20 or desmin.


Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature.

Almadani N, Alsaad KO, Al-Matrafi H, Al Hadab A, Abdullah N, AlKushi A - Urol Ann (2014)

Osteosarcoma of the urinary bladder with malignant osteoid formation and chondroid differentiation (H and E, ×200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127865&req=5

Figure 3: Osteosarcoma of the urinary bladder with malignant osteoid formation and chondroid differentiation (H and E, ×200)
Mentions: Light microscopic examination was performed on 5 μ thick sections from formaldehyde-fixed, paraffin embedded tissue, and showed malignant spindle cell proliferation with neoplastic osteoid formation, surrounded by abundant malignant chondroid matrix [Figure 3]. There was no evidence of urothelial carcinoma in situ, or invasive papillary urothelial carcinoma. A panel of immunohistochemical stains was performed. The neoplastic spindle cells showed strong and diffuse immunoreactivity to vimentin, while the chondroid component of the tumor was positive for S100-protein. There was no staining for pan-cytokeratin, CK7, CK20 or desmin.

Bottom Line: Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood.We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder.In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City and College of Medicine, King Saud University for Health Sciences, Riyadh, Saudi Arabia.

ABSTRACT
Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood. They are generally classified into either skeletal osteosarcomas, or their and rare soft tissue counterpart. The occurrence of osteosarcoma in the urinary bladder (UB) following radiotherapy is exceedingly rare. To the best of our knowledge, only two cases of radiation-related urinary bladder osteosarcoma have been published; we herein describe another case of an 85-year-old man who developed post radiotherapy chondroblastic osteosarcoma of the urinary bladder four years following initial surgical resection and radiotherapy for bladder urothelial carcinoma. We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder. In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

No MeSH data available.


Related in: MedlinePlus