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Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature.

Almadani N, Alsaad KO, Al-Matrafi H, Al Hadab A, Abdullah N, AlKushi A - Urol Ann (2014)

Bottom Line: Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood.We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder.In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City and College of Medicine, King Saud University for Health Sciences, Riyadh, Saudi Arabia.

ABSTRACT
Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood. They are generally classified into either skeletal osteosarcomas, or their and rare soft tissue counterpart. The occurrence of osteosarcoma in the urinary bladder (UB) following radiotherapy is exceedingly rare. To the best of our knowledge, only two cases of radiation-related urinary bladder osteosarcoma have been published; we herein describe another case of an 85-year-old man who developed post radiotherapy chondroblastic osteosarcoma of the urinary bladder four years following initial surgical resection and radiotherapy for bladder urothelial carcinoma. We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder. In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

No MeSH data available.


Related in: MedlinePlus

Solid nests of high-grade urothelial carcinoma infiltrating the muscularis propria of the urinary bladder (H and E, ×200)
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Figure 1: Solid nests of high-grade urothelial carcinoma infiltrating the muscularis propria of the urinary bladder (H and E, ×200)

Mentions: An 85-year-old man, known case of long-standing diabetes mellitus, hypertension and hyperlipidemia, presented to the emergency room with a history of sudden onset of gross hematuria. His surgical history was remarkable for previous aortic valve replacement surgery and transurethral resection of right posterior lateral exophytic UB tumor 47 months prior. Pathological examination of the UB tumor showed a high-grade papillary urothelial carcinoma with deep invasion into the muscularis propria (Stage pT2b) [Figure 1]. There was no evidence of sarcomatoid differentiation. The metastatic workup was negative. The patient was deemed a poor surgical candidate due to his medical co-morbidities, and received 66 Gy in 33 fractions of radiotherapy for seven weeks. Forty months following transurethral resection of the UB tumor, his cystoscopy and radiological workup showed no local recurrence or distant metastases.


Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature.

Almadani N, Alsaad KO, Al-Matrafi H, Al Hadab A, Abdullah N, AlKushi A - Urol Ann (2014)

Solid nests of high-grade urothelial carcinoma infiltrating the muscularis propria of the urinary bladder (H and E, ×200)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127865&req=5

Figure 1: Solid nests of high-grade urothelial carcinoma infiltrating the muscularis propria of the urinary bladder (H and E, ×200)
Mentions: An 85-year-old man, known case of long-standing diabetes mellitus, hypertension and hyperlipidemia, presented to the emergency room with a history of sudden onset of gross hematuria. His surgical history was remarkable for previous aortic valve replacement surgery and transurethral resection of right posterior lateral exophytic UB tumor 47 months prior. Pathological examination of the UB tumor showed a high-grade papillary urothelial carcinoma with deep invasion into the muscularis propria (Stage pT2b) [Figure 1]. There was no evidence of sarcomatoid differentiation. The metastatic workup was negative. The patient was deemed a poor surgical candidate due to his medical co-morbidities, and received 66 Gy in 33 fractions of radiotherapy for seven weeks. Forty months following transurethral resection of the UB tumor, his cystoscopy and radiological workup showed no local recurrence or distant metastases.

Bottom Line: Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood.We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder.In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City and College of Medicine, King Saud University for Health Sciences, Riyadh, Saudi Arabia.

ABSTRACT
Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood. They are generally classified into either skeletal osteosarcomas, or their and rare soft tissue counterpart. The occurrence of osteosarcoma in the urinary bladder (UB) following radiotherapy is exceedingly rare. To the best of our knowledge, only two cases of radiation-related urinary bladder osteosarcoma have been published; we herein describe another case of an 85-year-old man who developed post radiotherapy chondroblastic osteosarcoma of the urinary bladder four years following initial surgical resection and radiotherapy for bladder urothelial carcinoma. We believe that this is the first case of radiation-related chondroblastic osteosarcoma arising in the urinary bladder. In addition, we review the literature and explore the possible histogenesis of this rare neoplasm.

No MeSH data available.


Related in: MedlinePlus