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Solitary extramedullary plasmacytoma of the penis.

Scarberry K, Jegalian A, Valent J, Wood HM - Urol Ann (2014)

Bottom Line: Solitary extramedullary plasmacytomas are rare plasma cell malignancies, particularly outside the upper aerodigestive tract.A 90-year-old male presented with a penile mass suspicious for penile carcinoma.Pathology revealed the tumor to be an Epstein-Barr virus-associated plasmacytoma with no radiographic evidence of bone or other soft tissue involvement.

View Article: PubMed Central - PubMed

Affiliation: Case Western Reserve University, SOM, Cleveland, Ohio, USA.

ABSTRACT
Solitary extramedullary plasmacytomas are rare plasma cell malignancies, particularly outside the upper aerodigestive tract. A 90-year-old male presented with a penile mass suspicious for penile carcinoma. Pathology revealed the tumor to be an Epstein-Barr virus-associated plasmacytoma with no radiographic evidence of bone or other soft tissue involvement. There was no laboratory evidence of multiple myeloma.

No MeSH data available.


Related in: MedlinePlus

Histopathological findings (×400) (a) Hematoxylin- and Eosin-stained sections show infiltrative sheets of a typical plasmacytoid cells. kappa and (b) lambda (c) light chain immunohistochemistry shows kappa light chain restriction, consistent with a monoclonal process (d) In situ hybridization for Epstein-Barr virus-encoded RNA shows diffuse positivity
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Figure 1: Histopathological findings (×400) (a) Hematoxylin- and Eosin-stained sections show infiltrative sheets of a typical plasmacytoid cells. kappa and (b) lambda (c) light chain immunohistochemistry shows kappa light chain restriction, consistent with a monoclonal process (d) In situ hybridization for Epstein-Barr virus-encoded RNA shows diffuse positivity

Mentions: Surprisingly, final pathology revealed infiltrative, atypical plasmacytoid cells [Figure 1a]. Immunohistochemical and in situ hybridization led to the diagnosis of a plasma cell neoplasm, with positive staining for multiple myeloma oncogene 1 (MUM-1), syndecan 138(CD-138), monotypic kappa light chain, and Epstein-Barr virus-encoded ribonucleic acid (EBER) [Figure 1b–d]. EBER positivity raised the differential diagnosis of Epstein-Barr virus (EBV)-associated plasmacytoma or myeloma versus plasmablastic lymphoma. Morphological findings of mostly well-differentiated plasma cells with enlarged nuclei and prominent nucleoli were most consistent with the diagnosis of EBV-associated plasmacytoma.[1]


Solitary extramedullary plasmacytoma of the penis.

Scarberry K, Jegalian A, Valent J, Wood HM - Urol Ann (2014)

Histopathological findings (×400) (a) Hematoxylin- and Eosin-stained sections show infiltrative sheets of a typical plasmacytoid cells. kappa and (b) lambda (c) light chain immunohistochemistry shows kappa light chain restriction, consistent with a monoclonal process (d) In situ hybridization for Epstein-Barr virus-encoded RNA shows diffuse positivity
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127863&req=5

Figure 1: Histopathological findings (×400) (a) Hematoxylin- and Eosin-stained sections show infiltrative sheets of a typical plasmacytoid cells. kappa and (b) lambda (c) light chain immunohistochemistry shows kappa light chain restriction, consistent with a monoclonal process (d) In situ hybridization for Epstein-Barr virus-encoded RNA shows diffuse positivity
Mentions: Surprisingly, final pathology revealed infiltrative, atypical plasmacytoid cells [Figure 1a]. Immunohistochemical and in situ hybridization led to the diagnosis of a plasma cell neoplasm, with positive staining for multiple myeloma oncogene 1 (MUM-1), syndecan 138(CD-138), monotypic kappa light chain, and Epstein-Barr virus-encoded ribonucleic acid (EBER) [Figure 1b–d]. EBER positivity raised the differential diagnosis of Epstein-Barr virus (EBV)-associated plasmacytoma or myeloma versus plasmablastic lymphoma. Morphological findings of mostly well-differentiated plasma cells with enlarged nuclei and prominent nucleoli were most consistent with the diagnosis of EBV-associated plasmacytoma.[1]

Bottom Line: Solitary extramedullary plasmacytomas are rare plasma cell malignancies, particularly outside the upper aerodigestive tract.A 90-year-old male presented with a penile mass suspicious for penile carcinoma.Pathology revealed the tumor to be an Epstein-Barr virus-associated plasmacytoma with no radiographic evidence of bone or other soft tissue involvement.

View Article: PubMed Central - PubMed

Affiliation: Case Western Reserve University, SOM, Cleveland, Ohio, USA.

ABSTRACT
Solitary extramedullary plasmacytomas are rare plasma cell malignancies, particularly outside the upper aerodigestive tract. A 90-year-old male presented with a penile mass suspicious for penile carcinoma. Pathology revealed the tumor to be an Epstein-Barr virus-associated plasmacytoma with no radiographic evidence of bone or other soft tissue involvement. There was no laboratory evidence of multiple myeloma.

No MeSH data available.


Related in: MedlinePlus