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Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient.

Furudate S, Fujimura T, Kakizaki A, Kambayashi Y, Hashimoto A, Aiba S - Case Rep Dermatol (2014)

Bottom Line: Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with well-differentiated squamous cell carcinoma (SCC).An increased incidence of both KA and non-melanoma skin tumor, including SCC, is seen among immunosuppressed, organ-transplant recipients.In this report we describe a case of KA accompanied by multiple lung SCCs developing in a renal transplant recipient.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT
Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with well-differentiated squamous cell carcinoma (SCC). An increased incidence of both KA and non-melanoma skin tumor, including SCC, is seen among immunosuppressed, organ-transplant recipients. In this report we describe a case of KA accompanied by multiple lung SCCs developing in a renal transplant recipient.

No MeSH data available.


Related in: MedlinePlus

Cup-shaped, symmetrical, well-differentiated squamous epithelium with a mild degree of pleomorphism, individual cell keratinization and keratin pearls. Original magnification: ×100 (a), ×400 (b).
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Figure 2: Cup-shaped, symmetrical, well-differentiated squamous epithelium with a mild degree of pleomorphism, individual cell keratinization and keratin pearls. Original magnification: ×100 (a), ×400 (b).

Mentions: A 59-year-old Japanese male visited our outpatient clinic with a 2-month history of a rapid-growth red nodule on his left lower jaw. He had undergone renal transplantation and been administered cyclosporine 200 mg/day for 4 years. On his initial visit, physical examination revealed a dome-shaped, skin-colored, symmetrical, elastic-soft tumor covered with crust on his left lower jaw (fig. 1). The size of the tumor was approximately 17 mm in diameter. We excised the tumor with a 2-mm margin. Histological findings revealed a cup-shaped, symmetrical, well-differentiated squamous epithelium with a mild degree of pleomorphism, individual cell keratinization and keratin pearls (fig. 2). There was no sign of vascular or lymphatic invasion in the lesional skin. From the above findings, we diagnosed the cutaneous lesion as KA.


Keratoacanthoma accompanied by multiple lung squamous cell carcinomas developing in a renal transplant recipient.

Furudate S, Fujimura T, Kakizaki A, Kambayashi Y, Hashimoto A, Aiba S - Case Rep Dermatol (2014)

Cup-shaped, symmetrical, well-differentiated squamous epithelium with a mild degree of pleomorphism, individual cell keratinization and keratin pearls. Original magnification: ×100 (a), ×400 (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127547&req=5

Figure 2: Cup-shaped, symmetrical, well-differentiated squamous epithelium with a mild degree of pleomorphism, individual cell keratinization and keratin pearls. Original magnification: ×100 (a), ×400 (b).
Mentions: A 59-year-old Japanese male visited our outpatient clinic with a 2-month history of a rapid-growth red nodule on his left lower jaw. He had undergone renal transplantation and been administered cyclosporine 200 mg/day for 4 years. On his initial visit, physical examination revealed a dome-shaped, skin-colored, symmetrical, elastic-soft tumor covered with crust on his left lower jaw (fig. 1). The size of the tumor was approximately 17 mm in diameter. We excised the tumor with a 2-mm margin. Histological findings revealed a cup-shaped, symmetrical, well-differentiated squamous epithelium with a mild degree of pleomorphism, individual cell keratinization and keratin pearls (fig. 2). There was no sign of vascular or lymphatic invasion in the lesional skin. From the above findings, we diagnosed the cutaneous lesion as KA.

Bottom Line: Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with well-differentiated squamous cell carcinoma (SCC).An increased incidence of both KA and non-melanoma skin tumor, including SCC, is seen among immunosuppressed, organ-transplant recipients.In this report we describe a case of KA accompanied by multiple lung SCCs developing in a renal transplant recipient.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT
Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with well-differentiated squamous cell carcinoma (SCC). An increased incidence of both KA and non-melanoma skin tumor, including SCC, is seen among immunosuppressed, organ-transplant recipients. In this report we describe a case of KA accompanied by multiple lung SCCs developing in a renal transplant recipient.

No MeSH data available.


Related in: MedlinePlus