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Diagnosis of pulmonary tuberculosis and nontuberculous mycobacterial lung disease in Korea.

Kwon YS, Koh WJ - Tuberc Respir Dis (Seoul) (2014)

Bottom Line: The recovery of nontuberculous mycobacteria (NTM) from respiratory specimens and the number of patients with NTM lung disease have been rapidly increasing in Korea.An early differential diagnosis of NTM lung disease from pulmonary tuberculosis (TB) is important, as the therapeutic regimen differs from that of pulmonary TB, and it is not necessary to track the contacts of patients with NTM lung disease.However, differentiating NTM lung disease from pulmonary TB remains difficult, because the clinical presentations of the two diseases are similar and a definite diagnosis of NTM lung disease based on sputum culture takes time.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT
The recovery of nontuberculous mycobacteria (NTM) from respiratory specimens and the number of patients with NTM lung disease have been rapidly increasing in Korea. An early differential diagnosis of NTM lung disease from pulmonary tuberculosis (TB) is important, as the therapeutic regimen differs from that of pulmonary TB, and it is not necessary to track the contacts of patients with NTM lung disease. However, differentiating NTM lung disease from pulmonary TB remains difficult, because the clinical presentations of the two diseases are similar and a definite diagnosis of NTM lung disease based on sputum culture takes time. This review focuses on the changing epidemiology, clinical and radiographic manifestation, and laboratory diagnosis of pulmonary TB and NTM lung disease in Korea.

No MeSH data available.


Related in: MedlinePlus

Nodular bronchiectatic form of nontuberculous mycobacterial lung disease in a 60-year-old female with Mycobacterium abscessus lung disease. Chest high-resolution computed tomography shows severe bronchiectasis in the right middle lobe and the lingular segment of the left upper lobe. Note the multiple small nodules suggesting bronchiolitis in both lungs.
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Figure 2: Nodular bronchiectatic form of nontuberculous mycobacterial lung disease in a 60-year-old female with Mycobacterium abscessus lung disease. Chest high-resolution computed tomography shows severe bronchiectasis in the right middle lobe and the lingular segment of the left upper lobe. Note the multiple small nodules suggesting bronchiolitis in both lungs.

Mentions: Alternatively, NTM lung disease can present with nodular infiltrates that frequently involve the right middle lobe or lingular segment of the left upper lobe (Figure 2). This form of disease is termed nodular bronchiectatic disease, and it occurs predominantly in postmenopausal, non-smoking females and tends to have a much slower progression than cavitary disease1. The nodular bronchiectatic form of NTM lung disease has unique body morphotypes including lower body mass index and body fat, increased height, and increased incidence of scoliosis and pectus excavatum than control subjects33,34. Similar clinical manifestations have also been found in Korean patients35. Although bilateral bronchiectasis and bronchiolitis at HRCT also suggested NTM lung disease, there is considerable overlap in the radiographic manifestations of pulmonary TB and NTM lung disease, and radiographic findings alone could not differentiate the two diseases36.


Diagnosis of pulmonary tuberculosis and nontuberculous mycobacterial lung disease in Korea.

Kwon YS, Koh WJ - Tuberc Respir Dis (Seoul) (2014)

Nodular bronchiectatic form of nontuberculous mycobacterial lung disease in a 60-year-old female with Mycobacterium abscessus lung disease. Chest high-resolution computed tomography shows severe bronchiectasis in the right middle lobe and the lingular segment of the left upper lobe. Note the multiple small nodules suggesting bronchiolitis in both lungs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127406&req=5

Figure 2: Nodular bronchiectatic form of nontuberculous mycobacterial lung disease in a 60-year-old female with Mycobacterium abscessus lung disease. Chest high-resolution computed tomography shows severe bronchiectasis in the right middle lobe and the lingular segment of the left upper lobe. Note the multiple small nodules suggesting bronchiolitis in both lungs.
Mentions: Alternatively, NTM lung disease can present with nodular infiltrates that frequently involve the right middle lobe or lingular segment of the left upper lobe (Figure 2). This form of disease is termed nodular bronchiectatic disease, and it occurs predominantly in postmenopausal, non-smoking females and tends to have a much slower progression than cavitary disease1. The nodular bronchiectatic form of NTM lung disease has unique body morphotypes including lower body mass index and body fat, increased height, and increased incidence of scoliosis and pectus excavatum than control subjects33,34. Similar clinical manifestations have also been found in Korean patients35. Although bilateral bronchiectasis and bronchiolitis at HRCT also suggested NTM lung disease, there is considerable overlap in the radiographic manifestations of pulmonary TB and NTM lung disease, and radiographic findings alone could not differentiate the two diseases36.

Bottom Line: The recovery of nontuberculous mycobacteria (NTM) from respiratory specimens and the number of patients with NTM lung disease have been rapidly increasing in Korea.An early differential diagnosis of NTM lung disease from pulmonary tuberculosis (TB) is important, as the therapeutic regimen differs from that of pulmonary TB, and it is not necessary to track the contacts of patients with NTM lung disease.However, differentiating NTM lung disease from pulmonary TB remains difficult, because the clinical presentations of the two diseases are similar and a definite diagnosis of NTM lung disease based on sputum culture takes time.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT
The recovery of nontuberculous mycobacteria (NTM) from respiratory specimens and the number of patients with NTM lung disease have been rapidly increasing in Korea. An early differential diagnosis of NTM lung disease from pulmonary tuberculosis (TB) is important, as the therapeutic regimen differs from that of pulmonary TB, and it is not necessary to track the contacts of patients with NTM lung disease. However, differentiating NTM lung disease from pulmonary TB remains difficult, because the clinical presentations of the two diseases are similar and a definite diagnosis of NTM lung disease based on sputum culture takes time. This review focuses on the changing epidemiology, clinical and radiographic manifestation, and laboratory diagnosis of pulmonary TB and NTM lung disease in Korea.

No MeSH data available.


Related in: MedlinePlus