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Alteration of interictal brain activity in patients with temporal lobe epilepsy in the left dominant hemisphere: a resting-state MEG study.

Zhu H, Zhu J, Zhao T, Wu Y, Liu H, Wu T, Yang L, Zou Y, Zhang R, Zheng G - Biomed Res Int (2014)

Bottom Line: Significantly elevated SAMg2 signals were found in LTLE patients in the left temporal lobe and medial structures.Marked decreases of SAMg2 signals were found in the wide extratemporal lobe regions, such as the bilateral visual cortex.These results suggested that the aberrant brain activities not only were related to the epileptogenic zones, but also existed in other extratemporal regions in patients with LTLE.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, China.

ABSTRACT
Resting MEG activities were compared between patients with left temporal lobe epilepsy (LTLE) and normal controls. Using SAMg2, the activities of MEG data were reconstructed and normalized. Significantly elevated SAMg2 signals were found in LTLE patients in the left temporal lobe and medial structures. Marked decreases of SAMg2 signals were found in the wide extratemporal lobe regions, such as the bilateral visual cortex. The study also demonstrated a positive correlation between the seizure frequency and brain activities of the abnormal regions after the multiple linear regression analysis. These results suggested that the aberrant brain activities not only were related to the epileptogenic zones, but also existed in other extratemporal regions in patients with LTLE. The activities of the aberrant regions could be further damaged with the increase of the seizure frequency. Our findings indicated that LTLE could be a multifocal disease, including complex epileptic networks and brain dysfunction networks.

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Related in: MedlinePlus

Statistical parametric maps depict SAMg2 increases (warm colors) and decreases (cool colors) in LTLE compared with controls. Significant increases occur in left side hippocampal gyrus, insula, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and Heschl gyrus, while decreases occur in the bilateral calcarine, cerebellum, cuneus, fusiform, lingual gyrus, occipital lobe, precuneus, left parietal gyrus, and contralateral precentral gyrus.
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fig1: Statistical parametric maps depict SAMg2 increases (warm colors) and decreases (cool colors) in LTLE compared with controls. Significant increases occur in left side hippocampal gyrus, insula, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and Heschl gyrus, while decreases occur in the bilateral calcarine, cerebellum, cuneus, fusiform, lingual gyrus, occipital lobe, precuneus, left parietal gyrus, and contralateral precentral gyrus.

Mentions: In the LTLE patients compared to gender and age matched healthy subjects, there was a significant reduction in SAM g2 signals in the bilateral calcarine, cerebellum, cuneus, fusiform, lingual gyrus, occipital lobe (superior, middle, and inferior gyrus), precuneus, left parietal gyrus, and contralateral precentral gyrus. Patients also showed increased SAM g2 signals in the ipsilateral (left side) hippocampal gyrus, insula, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and Heschl gyri (P < 0.05, FDR corrected) (Table 2 and Figure 1).


Alteration of interictal brain activity in patients with temporal lobe epilepsy in the left dominant hemisphere: a resting-state MEG study.

Zhu H, Zhu J, Zhao T, Wu Y, Liu H, Wu T, Yang L, Zou Y, Zhang R, Zheng G - Biomed Res Int (2014)

Statistical parametric maps depict SAMg2 increases (warm colors) and decreases (cool colors) in LTLE compared with controls. Significant increases occur in left side hippocampal gyrus, insula, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and Heschl gyrus, while decreases occur in the bilateral calcarine, cerebellum, cuneus, fusiform, lingual gyrus, occipital lobe, precuneus, left parietal gyrus, and contralateral precentral gyrus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127284&req=5

fig1: Statistical parametric maps depict SAMg2 increases (warm colors) and decreases (cool colors) in LTLE compared with controls. Significant increases occur in left side hippocampal gyrus, insula, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and Heschl gyrus, while decreases occur in the bilateral calcarine, cerebellum, cuneus, fusiform, lingual gyrus, occipital lobe, precuneus, left parietal gyrus, and contralateral precentral gyrus.
Mentions: In the LTLE patients compared to gender and age matched healthy subjects, there was a significant reduction in SAM g2 signals in the bilateral calcarine, cerebellum, cuneus, fusiform, lingual gyrus, occipital lobe (superior, middle, and inferior gyrus), precuneus, left parietal gyrus, and contralateral precentral gyrus. Patients also showed increased SAM g2 signals in the ipsilateral (left side) hippocampal gyrus, insula, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and Heschl gyri (P < 0.05, FDR corrected) (Table 2 and Figure 1).

Bottom Line: Significantly elevated SAMg2 signals were found in LTLE patients in the left temporal lobe and medial structures.Marked decreases of SAMg2 signals were found in the wide extratemporal lobe regions, such as the bilateral visual cortex.These results suggested that the aberrant brain activities not only were related to the epileptogenic zones, but also existed in other extratemporal regions in patients with LTLE.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, China.

ABSTRACT
Resting MEG activities were compared between patients with left temporal lobe epilepsy (LTLE) and normal controls. Using SAMg2, the activities of MEG data were reconstructed and normalized. Significantly elevated SAMg2 signals were found in LTLE patients in the left temporal lobe and medial structures. Marked decreases of SAMg2 signals were found in the wide extratemporal lobe regions, such as the bilateral visual cortex. The study also demonstrated a positive correlation between the seizure frequency and brain activities of the abnormal regions after the multiple linear regression analysis. These results suggested that the aberrant brain activities not only were related to the epileptogenic zones, but also existed in other extratemporal regions in patients with LTLE. The activities of the aberrant regions could be further damaged with the increase of the seizure frequency. Our findings indicated that LTLE could be a multifocal disease, including complex epileptic networks and brain dysfunction networks.

Show MeSH
Related in: MedlinePlus