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The effect of a community-based, primary health care exercise program on inflammatory biomarkers and hormone levels.

Papini CB, Nakamura PM, Zorzetto LP, Thompson JL, Phillips AC, Kokubun E - Mediators Inflamm. (2014)

Bottom Line: Repeated measures ANOVA analyses indicated that the intervention was effective in reducing CRP and TNFα after 1 year compared to baseline and 6 months (P < 0.05).There were no changes in IL10, IL6, and insulin after 1 year.However, leptin significantly increased at 1 year (P = 0.016).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Education, São Paulo State University, Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil.

ABSTRACT
The aim of this study was to analyze the impact of a community-based exercise program in primary care on inflammatory biomarkers and hormone levels. The 1-year quasiexperimental study involved 13 women (mean age = 56.8 ± 11.4 years) and it was developed in two basic health care units in Rio Claro City, Brazil. The physical exercise intervention was comprised of two, 60-minute sessions/week. The inflammatory biomarkers were measured at baseline, 6 months, and 1 year. Repeated measures ANOVA analyses indicated that the intervention was effective in reducing CRP and TNFα after 1 year compared to baseline and 6 months (P < 0.05). There were no changes in IL10, IL6, and insulin after 1 year. However, leptin significantly increased at 1 year (P = 0.016). The major finding of this study is that a community-based exercise program can result in a decrease or maintenance of inflammatory biomarkers after 1 year, and thus has the potential to be a viable public health approach for chronic disease prevention.

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Related in: MedlinePlus

Levels of C-reactive protein (CRP), interleukin 10 (IL10), interleukin 6 (IL6), tumor necrosis factor alpha (TNFα), leptin, and insulin at baseline, after 6 months, and after 1 year of exercise intervention.  *Statistically significant difference from baseline.  αStatistically significant difference from 6 months.
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fig2: Levels of C-reactive protein (CRP), interleukin 10 (IL10), interleukin 6 (IL6), tumor necrosis factor alpha (TNFα), leptin, and insulin at baseline, after 6 months, and after 1 year of exercise intervention.  *Statistically significant difference from baseline.  αStatistically significant difference from 6 months.

Mentions: Table 2 and Figure 2 illustrate the inflammatory biomarkers and hormone concentration levels and indicate the outcomes of statistical analyses between time at baseline, 6 months, and 1 year. CRP levels significantly decreased after 1 year of intervention (1.5 ± 1.0 mg·L−1) compared to baseline (3.4 ± 1.2 mg·L−1, P = 0.001) and 6 months (3.0 ± 1.2 mg·L−1, P = 0.003). A significant decrease in TNFα levels was shown after 1 year of intervention (56.6 ± 3.0 pg·mL−1) compared to baseline (10.6 ± 5.6 pg·mL−1, P = 0.001) and 6 months (7.6 ± 4.0 pg·mL−1, P = 0.004). IL10, IL6, and insulin did not change over 1 year (P > 0.05). Leptin levels were significantly increased after 1 year (7.6 ± 4.89 pg·mL−1) of intervention compared to baseline (2.69 ± 2.25 pg·mL−1, P = 0.016) and 6 months (2.3 ± 1.66 pg·mL−1, P = 0.003). The IL10/TNFα ratio increased after 1 year of intervention (BL = 0.59 ± 0.4; 6 M = 0.64 ± 0.2; 1 Y = 0.85 ± 0.3).


The effect of a community-based, primary health care exercise program on inflammatory biomarkers and hormone levels.

Papini CB, Nakamura PM, Zorzetto LP, Thompson JL, Phillips AC, Kokubun E - Mediators Inflamm. (2014)

Levels of C-reactive protein (CRP), interleukin 10 (IL10), interleukin 6 (IL6), tumor necrosis factor alpha (TNFα), leptin, and insulin at baseline, after 6 months, and after 1 year of exercise intervention.  *Statistically significant difference from baseline.  αStatistically significant difference from 6 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4127245&req=5

fig2: Levels of C-reactive protein (CRP), interleukin 10 (IL10), interleukin 6 (IL6), tumor necrosis factor alpha (TNFα), leptin, and insulin at baseline, after 6 months, and after 1 year of exercise intervention.  *Statistically significant difference from baseline.  αStatistically significant difference from 6 months.
Mentions: Table 2 and Figure 2 illustrate the inflammatory biomarkers and hormone concentration levels and indicate the outcomes of statistical analyses between time at baseline, 6 months, and 1 year. CRP levels significantly decreased after 1 year of intervention (1.5 ± 1.0 mg·L−1) compared to baseline (3.4 ± 1.2 mg·L−1, P = 0.001) and 6 months (3.0 ± 1.2 mg·L−1, P = 0.003). A significant decrease in TNFα levels was shown after 1 year of intervention (56.6 ± 3.0 pg·mL−1) compared to baseline (10.6 ± 5.6 pg·mL−1, P = 0.001) and 6 months (7.6 ± 4.0 pg·mL−1, P = 0.004). IL10, IL6, and insulin did not change over 1 year (P > 0.05). Leptin levels were significantly increased after 1 year (7.6 ± 4.89 pg·mL−1) of intervention compared to baseline (2.69 ± 2.25 pg·mL−1, P = 0.016) and 6 months (2.3 ± 1.66 pg·mL−1, P = 0.003). The IL10/TNFα ratio increased after 1 year of intervention (BL = 0.59 ± 0.4; 6 M = 0.64 ± 0.2; 1 Y = 0.85 ± 0.3).

Bottom Line: Repeated measures ANOVA analyses indicated that the intervention was effective in reducing CRP and TNFα after 1 year compared to baseline and 6 months (P < 0.05).There were no changes in IL10, IL6, and insulin after 1 year.However, leptin significantly increased at 1 year (P = 0.016).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Education, São Paulo State University, Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil.

ABSTRACT
The aim of this study was to analyze the impact of a community-based exercise program in primary care on inflammatory biomarkers and hormone levels. The 1-year quasiexperimental study involved 13 women (mean age = 56.8 ± 11.4 years) and it was developed in two basic health care units in Rio Claro City, Brazil. The physical exercise intervention was comprised of two, 60-minute sessions/week. The inflammatory biomarkers were measured at baseline, 6 months, and 1 year. Repeated measures ANOVA analyses indicated that the intervention was effective in reducing CRP and TNFα after 1 year compared to baseline and 6 months (P < 0.05). There were no changes in IL10, IL6, and insulin after 1 year. However, leptin significantly increased at 1 year (P = 0.016). The major finding of this study is that a community-based exercise program can result in a decrease or maintenance of inflammatory biomarkers after 1 year, and thus has the potential to be a viable public health approach for chronic disease prevention.

Show MeSH
Related in: MedlinePlus