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Pathological feature and immunoprofile of cystitis glandularis accompanied with upper urinary tract obstruction.

Li A, Zhou J, Lu H, Zuo X, Liu S, Zhang F, Li W, Fang W, Zhang B - Biomed Res Int (2014)

Bottom Line: In the two groups, main pathological type was transitional epithelial, followed by intestinal epithelial; other types were a few, and the difference between the two groups was not significant.Transitional epithelial type was compared with mixed type; the difference of COX-2 was significant, P < 0.05.It is suggested that glandular cystitis accompanied with upper urinary tract obstruction shares the same pathological feature and immunoprofile as that without upper urinary tract obstruction.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.

ABSTRACT

Objective: To explore the pathological feature and immunoprofile of immunoprofile accompanied with upper urinary tract obstruction and the immunoprofile in various types of glandular cystitis.

Methods: Pathological sections from 31 cases of cystitis glandularis with upper urinary tract obstruction and 34 cases of cystitis glandularis without upper urinary tract obstruction were observed as pathological feature on microscopy. Meanwhile, an immunohistochemical analysis was employed to determine the expression of p53, Ki67, p21, MMP-9, MUC1, MUC2, and COX-2.

Results: In the two groups, main pathological type was transitional epithelial, followed by intestinal epithelial; other types were a few, and the difference between the two groups was not significant. All immunohistochemical expressions of p53, Ki67, p21, MMP-9, MUC1, MUC2, and COX-2 were positive in varying degrees, and there was no significant difference between the groups. Transitional epithelial type was compared with mixed type; the difference of COX-2 was significant, P < 0.05. The differences of immunohistochemical expression among other different pathologic types were not significant.

Conclusions: It is suggested that glandular cystitis accompanied with upper urinary tract obstruction shares the same pathological feature and immunoprofile as that without upper urinary tract obstruction. No significant differences of immunohistochemical expression in tissue are in cystitis glandularis with different pathological types.

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Immunohistochemical analysis of cystitis glandularis. (a) demonstrates positive nuclear staining for p53; (b) demonstrates positive nuclear staining for p21; (c) demonstrates positive nuclear staining for Ki-67; (d) demonstrates positive cytoplasmic staining for MMP-9; (e) demonstrates positive cytoplasmic staining for MUC2; (f) demonstrates positive cytoplasmic staining for COX-2; (g) demonstrates positive cytoplasmic staining or luminal membrane staining for MUC1.
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fig1: Immunohistochemical analysis of cystitis glandularis. (a) demonstrates positive nuclear staining for p53; (b) demonstrates positive nuclear staining for p21; (c) demonstrates positive nuclear staining for Ki-67; (d) demonstrates positive cytoplasmic staining for MMP-9; (e) demonstrates positive cytoplasmic staining for MUC2; (f) demonstrates positive cytoplasmic staining for COX-2; (g) demonstrates positive cytoplasmic staining or luminal membrane staining for MUC1.

Mentions: Nuclear staining of p53, p21, and Ki-67, cytoplasmic staining of MMP-9, MUC2, and COX-2, and cytoplasmic staining or luminal membrane staining of MUC1 were considered positive (Figure 1).


Pathological feature and immunoprofile of cystitis glandularis accompanied with upper urinary tract obstruction.

Li A, Zhou J, Lu H, Zuo X, Liu S, Zhang F, Li W, Fang W, Zhang B - Biomed Res Int (2014)

Immunohistochemical analysis of cystitis glandularis. (a) demonstrates positive nuclear staining for p53; (b) demonstrates positive nuclear staining for p21; (c) demonstrates positive nuclear staining for Ki-67; (d) demonstrates positive cytoplasmic staining for MMP-9; (e) demonstrates positive cytoplasmic staining for MUC2; (f) demonstrates positive cytoplasmic staining for COX-2; (g) demonstrates positive cytoplasmic staining or luminal membrane staining for MUC1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4127228&req=5

fig1: Immunohistochemical analysis of cystitis glandularis. (a) demonstrates positive nuclear staining for p53; (b) demonstrates positive nuclear staining for p21; (c) demonstrates positive nuclear staining for Ki-67; (d) demonstrates positive cytoplasmic staining for MMP-9; (e) demonstrates positive cytoplasmic staining for MUC2; (f) demonstrates positive cytoplasmic staining for COX-2; (g) demonstrates positive cytoplasmic staining or luminal membrane staining for MUC1.
Mentions: Nuclear staining of p53, p21, and Ki-67, cytoplasmic staining of MMP-9, MUC2, and COX-2, and cytoplasmic staining or luminal membrane staining of MUC1 were considered positive (Figure 1).

Bottom Line: In the two groups, main pathological type was transitional epithelial, followed by intestinal epithelial; other types were a few, and the difference between the two groups was not significant.Transitional epithelial type was compared with mixed type; the difference of COX-2 was significant, P < 0.05.It is suggested that glandular cystitis accompanied with upper urinary tract obstruction shares the same pathological feature and immunoprofile as that without upper urinary tract obstruction.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.

ABSTRACT

Objective: To explore the pathological feature and immunoprofile of immunoprofile accompanied with upper urinary tract obstruction and the immunoprofile in various types of glandular cystitis.

Methods: Pathological sections from 31 cases of cystitis glandularis with upper urinary tract obstruction and 34 cases of cystitis glandularis without upper urinary tract obstruction were observed as pathological feature on microscopy. Meanwhile, an immunohistochemical analysis was employed to determine the expression of p53, Ki67, p21, MMP-9, MUC1, MUC2, and COX-2.

Results: In the two groups, main pathological type was transitional epithelial, followed by intestinal epithelial; other types were a few, and the difference between the two groups was not significant. All immunohistochemical expressions of p53, Ki67, p21, MMP-9, MUC1, MUC2, and COX-2 were positive in varying degrees, and there was no significant difference between the groups. Transitional epithelial type was compared with mixed type; the difference of COX-2 was significant, P < 0.05. The differences of immunohistochemical expression among other different pathologic types were not significant.

Conclusions: It is suggested that glandular cystitis accompanied with upper urinary tract obstruction shares the same pathological feature and immunoprofile as that without upper urinary tract obstruction. No significant differences of immunohistochemical expression in tissue are in cystitis glandularis with different pathological types.

Show MeSH
Related in: MedlinePlus