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Induced effects of transcranial magnetic stimulation on the autonomic nervous system and the cardiac rhythm.

Cabrerizo M, Cabrera A, Perez JO, de la Rua J, Rojas N, Zhou Q, Pinzon-Ardila A, Gonzalez-Arias SM, Adjouadi M - ScientificWorldJournal (2014)

Bottom Line: The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases.Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio.The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

View Article: PubMed Central - PubMed

Affiliation: Center for Advanced Technology and Education, Department of Electrical and Computer Engineering, College of Engineering and Computing, Florida International University (FIU), USA.

ABSTRACT
Several standard protocols based on repetitive transcranial magnetic stimulation (rTMS) have been employed for treatment of a variety of neurological disorders. Despite their advantages in patients that are retractable to medication, there is a lack of knowledge about the effects of rTMS on the autonomic nervous system that controls the cardiovascular system. Current understanding suggests that the shape of the so-called QRS complex together with the size of the different segments and intervals between the PQRST deflections of the heart could predict the nature of the different arrhythmias and ailments affecting the heart. This preliminary study involving 10 normal subjects from 20 to 30 years of age demonstrated that rTMS can induce changes in the heart rhythm. The autonomic activity that controls the cardiac rhythm was indeed altered by an rTMS session targeting the motor cortex using intensity below the subject's motor threshold and lasting no more than 5 minutes. The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases. Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio. The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

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Related in: MedlinePlus

12-lead ECG recording. Note: stimuli artifact (1 sec, 10 Hz) is seen at the beginning of recording in several leads.
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fig3: 12-lead ECG recording. Note: stimuli artifact (1 sec, 10 Hz) is seen at the beginning of recording in several leads.

Mentions: The TMS session applied to the subject in order to record the ECG signals was delivered by the in-house developed software, which is fully compatible with and coupled effectively to the TMS machine. An extended ECG montage with 12 leads was simultaneously recorded as illustrated in Figure 3 and stored in a computer, making it amenable to real time ECG monitoring. During the offline analysis of the ECG, normal RR intervals were automatically identified, removing those intervals altered by noise or by a surge of ectopic beats, a disturbance of the cardiac rhythm. These intervals were replaced by a mean RR interval value calculated automatically by the software.


Induced effects of transcranial magnetic stimulation on the autonomic nervous system and the cardiac rhythm.

Cabrerizo M, Cabrera A, Perez JO, de la Rua J, Rojas N, Zhou Q, Pinzon-Ardila A, Gonzalez-Arias SM, Adjouadi M - ScientificWorldJournal (2014)

12-lead ECG recording. Note: stimuli artifact (1 sec, 10 Hz) is seen at the beginning of recording in several leads.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4127210&req=5

fig3: 12-lead ECG recording. Note: stimuli artifact (1 sec, 10 Hz) is seen at the beginning of recording in several leads.
Mentions: The TMS session applied to the subject in order to record the ECG signals was delivered by the in-house developed software, which is fully compatible with and coupled effectively to the TMS machine. An extended ECG montage with 12 leads was simultaneously recorded as illustrated in Figure 3 and stored in a computer, making it amenable to real time ECG monitoring. During the offline analysis of the ECG, normal RR intervals were automatically identified, removing those intervals altered by noise or by a surge of ectopic beats, a disturbance of the cardiac rhythm. These intervals were replaced by a mean RR interval value calculated automatically by the software.

Bottom Line: The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases.Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio.The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

View Article: PubMed Central - PubMed

Affiliation: Center for Advanced Technology and Education, Department of Electrical and Computer Engineering, College of Engineering and Computing, Florida International University (FIU), USA.

ABSTRACT
Several standard protocols based on repetitive transcranial magnetic stimulation (rTMS) have been employed for treatment of a variety of neurological disorders. Despite their advantages in patients that are retractable to medication, there is a lack of knowledge about the effects of rTMS on the autonomic nervous system that controls the cardiovascular system. Current understanding suggests that the shape of the so-called QRS complex together with the size of the different segments and intervals between the PQRST deflections of the heart could predict the nature of the different arrhythmias and ailments affecting the heart. This preliminary study involving 10 normal subjects from 20 to 30 years of age demonstrated that rTMS can induce changes in the heart rhythm. The autonomic activity that controls the cardiac rhythm was indeed altered by an rTMS session targeting the motor cortex using intensity below the subject's motor threshold and lasting no more than 5 minutes. The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases. Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio. The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

Show MeSH
Related in: MedlinePlus